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Synthesis of antiaromatic thiazinoindolizines based on electrophilic cyclizations of indolizine-5-thione

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Chemistry of Heterocyclic Compounds Aims and scope

Alkylation of indolizinethione at the sulfur atom by the action of RCOCH2Br (R = Me, Ar, CO2Me, OEt) leads to thioethers, and subsequent closure of the thiazine ring of which leads to the formation of stable antiaromatic thiazino[4,3,2-cd]indolizines.

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Authors and Affiliations

  1. Lomonosov Moscow State University, 1, Build. 3, Moscow, 119992, Russia

    Eugene V. Babaev, Aleksandra А. Nevskaya, Ilya V. Dlynnikh & Victor B. Rybakov

  2. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow, 119991, Russia

    Eugene V. Babaev

Authors
  1. Eugene V. Babaev
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  2. Aleksandra А. Nevskaya
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  3. Ilya V. Dlynnikh
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  4. Victor B. Rybakov
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Correspondence to Eugene V. Babaev.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2020, 56(7), 942–948

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Babaev, E.V., Nevskaya, A.А., Dlynnikh, I.V. et al. Synthesis of antiaromatic thiazinoindolizines based on electrophilic cyclizations of indolizine-5-thione. Chem Heterocycl Comp 56, 942–948 (2020). https://doi.org/10.1007/s10593-020-02754-w

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  • DOI: https://doi.org/10.1007/s10593-020-02754-w

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