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Synthesis of Fluorinated Octahydro-2H-Chromenes in the Presence of the BF3·Et2O–H2O Catalytic System

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Chemistry of Heterocyclic Compounds Aims and scope

The synthesis of fluorinated octahydro-2H-chromene was carried out using the Prins reaction between the monoterpenoid (–)-isopulegol and carbonyl compounds in the presence of the BF3·Et2O–H2O system, which acts as both an acid catalyst and a fluorine source. The use of the readily available and easy-to-use BF3·Et2O reagent makes this method of obtaining fluorine derivatives simple and practical.

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Authors and Affiliations

  1. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 Akademika Lavrentieva Ave, Novosibirsk, 630090, Russia

    Irina V. Il’ina, Oksana S. Patrusheva, Dina V. Korchagina, Konstantin P. Volcho & Nariman F. Salakhutdinov

  2. Novosibirsk State University, 2 Pirogova St, Novosibirsk, 630090, Russia

    Konstantin P. Volcho & Nariman F. Salakhutdinov

Authors
  1. Irina V. Il’ina
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  2. Oksana S. Patrusheva
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  3. Dina V. Korchagina
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  4. Konstantin P. Volcho
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  5. Nariman F. Salakhutdinov
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Correspondence to Konstantin P. Volcho.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2020, 56(7), 867–874

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Il’ina, I.V., Patrusheva, O.S., Korchagina, D.V. et al. Synthesis of Fluorinated Octahydro-2H-Chromenes in the Presence of the BF3·Et2O–H2O Catalytic System. Chem Heterocycl Comp 56, 867–874 (2020). https://doi.org/10.1007/s10593-020-02743-z

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  • DOI: https://doi.org/10.1007/s10593-020-02743-z

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