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The role of Th17 cells in psoriasis

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Abstract

T helper 17 (Th17) cells have been involved in the pathogenesis of many autoimmune and inflammatory diseases, like psoriasis, multiple sclerosis (MS), rheumatoid arthritis (RA), and inflammatory bowel disease (IBD). However, the role of Th17 cells in psoriasis has not been clarified completely. Th17-derived proinflammatory cytokines including IL-17A, IL-17F, IL-21, IL-22, and IL-26 have a critical role in the pathogenesis of these disorders. In this review, we introduced the signaling and transcriptional regulation of Th17 cells. And then, we demonstrate the immunopathology role of Th17 cells and functions of the related cytokines in the psoriasis to get a better understanding of the inflammatory mechanisms mediated by Th17 cells in this disease.

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Funding

This study was sponsored by China Pharmaceutical University “Double First-Class” University project (CPU2018GY32), National Major Scientific and Technological Special Project for “Significant New Drugs Development” during the Thirteenth Five-year Plan Period (No. 2016ZX09101031) and China Pharmaceutical University “Double First-Class” Construction Graduate Education and Teaching Project (JGYB201909).

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  1. State Key Laboratory of Natural Medicines, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Mailbox 207, Tongjiaxiang 24, Nanjing, Jiangsu, 210009, People’s Republic of China

    Binbin Li, Liangliang Huang, Xiang Li, Ge Liu, Yan Chen, Ziyu Wang, Xiaoxian Qian, Yixiao Shen, Yunman Li & Weirong Fang

  2. Chia Tai Tianqing Pharmaceutical Group Co. Ltd., No.1099, Fuying Road, Jiangning District, Nanjing, Jiangsu Province, 211122, People’s Republic of China

    Binbin Li & Peng Lv

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  1. Binbin Li
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Binbin Li, Liangliang Huang: Conception and design

Binbin Li, Peng Lv, Xiang Li, Ge Liu, Yan Chen, Ziyu Wang, Xiaoxian Qian, Yixiao Shen: Acquisition of data

Binbin Li, Weirong Fang, Liangliang Huang, Peng Lv: Writing, review, and revision of the manuscript

Weirong Fang, Yunman Li: Study supervision

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Li, B., Huang, L., Lv, P. et al. The role of Th17 cells in psoriasis. Immunol Res 68, 296–309 (2020). https://doi.org/10.1007/s12026-020-09149-1

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