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Effect of mesoporous characteristics on competitive adsorption kinetics of uremic-like toxin and atorvastatin on spherical carbon adsorbents for an in vitro chronic renal failure therapeutic model

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Abstract

Indole-3-acetic acid (IA, urine-like toxin) coexisting with atorvastatin (AT) was adsorbed by spherical carbonaceous adsorbents (SCs). The relationship between the competitive adsorption kinetics and the mesoporous structures was investigated. The pore structures of the four SCs were analyzed using the Hg and gas adsorption methods. SC adsorption tests were performed using the dissolution test with the paddle method with an SC sample in distilled water containing IA and/or AT at 37.0 °C. The amounts of IA and AT adsorbed on SCs in single- and binary-drug administration tests were measured based on the ultraviolet-visible spectra using classical least squares analysis. Rate constants for the drug adsorption of IA and AT by SCs (kIA and kAT, respectively) were suppressed by the effect of coexisting drugs. The suppression of IA adsorption by the coexisting drug was dependent on the pore structure of the SCs. kIA and kAT against the SCs were competitively inhibited by coexisting drugs.

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Funding

This research received partial financial support from the Creating Happiness Incubation, Musashino University (No. 23).

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Authors and Affiliations

  1. Faculty of Pharmacy, Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20 Shinmachi, Nishi-Tokyo, Tokyo, 202-8585, Japan

    Yayoi Nitta, Yusuke Hattori & Makoto Otsuka

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  1. Yayoi Nitta
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  2. Yusuke Hattori
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  3. Makoto Otsuka
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Correspondence to Makoto Otsuka.

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Nitta, Y., Hattori, Y. & Otsuka, M. Effect of mesoporous characteristics on competitive adsorption kinetics of uremic-like toxin and atorvastatin on spherical carbon adsorbents for an in vitro chronic renal failure therapeutic model. Colloid Polym Sci 298, 1487–1500 (2020). https://doi.org/10.1007/s00396-020-04729-x

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