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CELL POLARITY

Apical poles without neighbouring cells

Nature Materials volume 19, pages 935–937 (2020)Cite this article

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Functional single-cell liver hemi-canaliculi have been generated in a synthetic microenvironment using a reductionist approach. It is shown that the interaction between the extracellular matrix and static cadherin is sufficient to develop an apicobasal polarity independently of the contact with neighbouring cells.

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Fig. 1: The development of hepatocyte polarity during the stages of hemi-lumen formation.

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Authors and Affiliations

  1. Centro de Biología Molecular Severo Ochoa (CBMSO), Tissue and Organ Homeostasis Program, Consejo Superior de Investigaciones Científicas (CSIC) and Universidad Autónoma de Madrid (UAM), Madrid, Spain

    Covadonga Díaz-Díaz & Fernando Martín-Belmonte

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  1. Covadonga Díaz-Díaz
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  2. Fernando Martín-Belmonte
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Correspondence to Fernando Martín-Belmonte.

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Díaz-Díaz, C., Martín-Belmonte, F. Apical poles without neighbouring cells. Nat. Mater. 19, 935–937 (2020). https://doi.org/10.1038/s41563-020-0766-9

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