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8-Ethynylxanthines as promising antiproliferative agents, angiogenesis inhibitors, and calcium channel activity modulators

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Chemistry of Heterocyclic Compounds Aims and scope

Synthetic procedures for the preparation of 8-ethynylxanthines by treating 8-bromocaffeine and 8-bromopentoxifylline with terminal acetylenes were elaborated. Certain ethynylxanthine derivatives exhibit high in vitro antiproliferative activity against a panel of cancer cell lines, matrix metalloproteinase and in vitro angiogenesis inhibitory activity. Ca2+ channel blocking and agonist activity of the synthesized ethynylxanthines was discussed based on data obtained on the H9C2, SH-SY5Y, and A7R5 cell lines.

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Authors and Affiliations

  1. Latvian Institute of Organic Synthesis, 21 Aizkraukles St, Riga, LV-1006, Latvia

    Pavel Arsenyan, Jelena Vasiljeva, Ilona Domracheva & Iveta Kanepe-Lapsa

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  1. Pavel Arsenyan
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  2. Jelena Vasiljeva
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  3. Ilona Domracheva
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  4. Iveta Kanepe-Lapsa
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Correspondence to Pavel Arsenyan.

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Arsenyan, P., Vasiljeva, J., Domracheva, I. et al. 8-Ethynylxanthines as promising antiproliferative agents, angiogenesis inhibitors, and calcium channel activity modulators. Chem Heterocycl Comp 56, 776–785 (2020). https://doi.org/10.1007/s10593-020-02730-4

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  • DOI: https://doi.org/10.1007/s10593-020-02730-4

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