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Development of Technology and Equipment for Enisamium Iodide Drying

  • EQUIPMENT FOR CHEMICO-PHARMACEUTICAL PLANTS MECHANIZATION AND AUTOMATION OF TECHNOLOGICAL PROCESSES
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Pharmaceutical Chemistry Journal Aims and scope

A methodological approach to selecting the optimal drying method for enisamium iodide, an antiviral agent with a broad spectrum of pharmacological activities, is considered. A vacuum drying method in an apparatus with a tape mixing device is proposed and verified based on studies of the main properties of the product. An industrial setup prototype and design features of the apparatus are described. The basic technological regimes of enisamium iodide drying ensuring the product quality are established. The kinetic drying and heating curves of the product, including those in the optimal regime, are presented. Test results were used to determine the specific technical parameters of the setup operation.

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References

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  2. L. G. Golubev, B. S. Sazhin, and E. R. Valashek, Drying in the Chemico-Pharmaceutical Industry [in Russian], Meditsina, Moscow (1978).

  3. S. M. Reprintseva and I. V. Fedorovich, New Methods of Heat Treatment and Drying of Chemico-Pharmaceutical Preparations [in Russian], Nauka i Tekhnika, Minsk (1979).

  4. Z. Pakowski and A. S. Mujumdar, in: Handbook of Industrial Drying, A. S. Mujumdar (ed.), CRC Press, Taylor & Francis Group, New York (2006), pp. 689 – 712.

  5. N. I. Roshchin, Pseudoliquefaction in Drug Manufacturing [in Russian], Meditsina, Moscow (1981).

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Acknowledgments

Th work was performed using equipment at the Biysk Regional Common Use Center, SB, RAS (IPCET, SB, RAS, Biysk).

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Authors and Affiliations

  1. Institute for Problems of Chemical and Energetic Technologies, Siberian Branch, Russian Academy of Sciences, Altai Krai, Biysk, 659322, Russia

    M. S. Vasilishin, Yu. A. Kryukov, A. G. Karpov, O. S. Ivanov, D. B. Ivanova & S. V. Sysolyatin

  2. Biysk Technological Institute, I. I. Polzunov Altai State Technical University, Altai Krai, Biysk, 659305, Russia

    M. S. Vasilishin & A. V. Balakhnina

Authors
  1. M. S. Vasilishin
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  2. Yu. A. Kryukov
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  3. A. G. Karpov
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  4. O. S. Ivanov
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  5. D. B. Ivanova
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  6. S. V. Sysolyatin
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  7. A. V. Balakhnina
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Corresponding author

Correspondence to O. S. Ivanov.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 5, pp. 55 – 57, May, 2020.

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Vasilishin, M.S., Kryukov, Y.A., Karpov, A.G. et al. Development of Technology and Equipment for Enisamium Iodide Drying. Pharm Chem J 54, 536–538 (2020). https://doi.org/10.1007/s11094-020-02233-8

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  • DOI: https://doi.org/10.1007/s11094-020-02233-8

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