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Selective Urease Inhibitory and Antimicrobial Activities of Transition Metal Complexes of Amino Acid Bearing Schiff Base Ligand: Thermal Degradation Behavior of Complexes

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Pharmaceutical Chemistry Journal Aims and scope

Amino acid derived Schiff base ligand [1-({[(Z)-(2-hydroxynaphthalen-1-yl)methylidene]-amino}methyl)-cyclohexyl]acetic acid (H-HMAC) and its metal complexes with composition [M(HMAC)2] [M = Co(II), Ni(II), Cu(II), and Zn(II)] reported previously were studied for their thermal degradation, antimicrobial and inhibitory activities against the enzymes like urease, α-chymotrypsin, acetylcholinesterase and butyrylcholinesterase. Only a zinc-based compound of the zwitter-ion ligand has been found to inhibit the urease activity with IC50= 0.04 ± 0.01 μ M (value ± SEM), which is 400 times better than the standard reference drug used. Metal coordination with zinc improved the bioactivity and deserved for selective urease inhibitor development. The inhibitory activity was structurally rationalized by carrying out the molecular modeling studies using AutoDock software. The same metal complex was also observed to inhibit the activity of Candida albicans. The thermal degradation studies suggest that the order of stability and activation energies of all compounds is as follows: Cu < H-HMAC < Ni < Co = Zn and E*Zn> E*Co> E*Ni> E*Cu, respectively.

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Authors and Affiliations

  1. Department of Chemistry, AbdulWali Khan University, Mardan, Pakistan

    Muhammad Ikram, Sadia Rehman, Fazle Subhan & Sobia Aslam

  2. Department of Chemistry, University of Agriculture, Faisalabad, Pakistan

    Muhammad Nadeem Akhtar

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  1. Muhammad Ikram
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  2. Sadia Rehman
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  3. Muhammad Nadeem Akhtar
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  4. Fazle Subhan
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  5. Sobia Aslam
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Correspondence to Muhammad Ikram.

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Ikram, M., Rehman, S., Akhtar, M.N. et al. Selective Urease Inhibitory and Antimicrobial Activities of Transition Metal Complexes of Amino Acid Bearing Schiff Base Ligand: Thermal Degradation Behavior of Complexes. Pharm Chem J 54, 469–477 (2020). https://doi.org/10.1007/s11094-020-02224-9

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  • DOI: https://doi.org/10.1007/s11094-020-02224-9

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