In vivo monitoring of carbonic anhydrase expression during the growth of larval zebrafish: a new environment-sensitive fluorophore for responsive turn-on fluorescence

Chih-Hung Chou; Chang-Yi Wu; Chun-Lin Chen; Jun-Qing Zhou; Yu-Chen Kao; Hsing-Yin Chen; Po-Chiao Lin

doi:10.1039/D0CC03090B

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In vivo monitoring of carbonic anhydrase expression during the growth of larval zebrafish: a new environment-sensitive fluorophore for responsive turn-on fluorescence†

Chih-Hung Chou,

^a Chang-Yi Wu,^b Chun-Lin Chen,

^b Jun-Qing Zhou,^b Yu-Chen Kao,^b Hsing-Yin Chen

^c and Po-Chiao Lin

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
E-mail: pclin@mail.nsysu.edu.tw

^b Department of Biological Science, National Sun Yat-sen University, Kaohsiung 80424, Taiwan

^c Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

Abstract

This study monitors the dynamic progress of a newly developed background-free, target responsive strategy; 2,3-dihydroquinolin-4-imine (DQI) that can instantly respond to environmental changes with fluorescence enhancement, revealing a comprehensive platform for in vivo fluorescence bioimaging of mebrane-bound carbonic anhydrase II in HeLa cells and its expression during the growth of larval zebrafish.

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Article information

DOI: https://doi.org/10.1039/D0CC03090B
Article type: Communication
Submitted: 29 Apr 2020
Accepted: 08 Aug 2020
First published: 19 Aug 2020

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Chem. Commun., 2020,56, 11307-11310

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In vivo monitoring of carbonic anhydrase expression during the growth of larval zebrafish: a new environment-sensitive fluorophore for responsive turn-on fluorescence

C. Chou, C. Wu, C. Chen, J. Zhou, Y. Kao, H. Chen and P. Lin, Chem. Commun., 2020, 56, 11307 DOI: 10.1039/D0CC03090B

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Chemical Communications

In vivo monitoring of carbonic anhydrase expression during the growth of larval zebrafish: a new environment-sensitive fluorophore for responsive turn-on fluorescence†

Abstract

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In vivo monitoring of carbonic anhydrase expression during the growth of larval zebrafish: a new environment-sensitive fluorophore for responsive turn-on fluorescence

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