Five compounds (1 -– 5) were isolated from the leaves of Gomphrena celosioides Mart species harvested in Nam Dinh province and studied by chromatographic method. These compounds were identified as cleomiscosin A(1), dictyoceratin- C (2), ilimaquinone (3), bruceolline F (4), and neodactyloquinone (5). Their structures were elucidated by spectroscopic techniques including mass spectrometry (MS) and nuclear magnetic resonance (NMR). These compounds were isolated from the leaves of G. celosioides for the first time. All compounds were evaluated for their hypoglycemic activity in PTP1B inhibition and glucose uptake into 3T3-L1 adipocytes enhancement models. Results showed that compound 5 produced maximum effect with PTP1B inhibitory activity of 80.39 ± 6.88%, IC50 = 42.78 ± 2.86 μM, as well as the strongest ability to enhance glucose uptake in 3T3-L1 adipocytes.
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Acknowledgement
This research was supported and financed by the Vietnam National University (Hanoi) with grant number QG.19.86
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Duc, L.V., Le Hong, D. & Hoang, G.D. Hypoglycemic Activity of Isolated Compounds from Gomphrena celosioides Mart. Pharm Chem J 54, 484–489 (2020). https://doi.org/10.1007/s11094-020-02226-7
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DOI: https://doi.org/10.1007/s11094-020-02226-7