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BRAIN TUMORS

Super-sonic speed of DNA synthesis in medulloblastoma

Nature Cancer volume 1, pages 758–760 (2020)Cite this article

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Replication stress fuels chromosomal instability, tumor heterogeneity and therapy resistance. The Sonic hedgehog pathway is now linked to an unorthodox form of replication stress in cerebellar granular-cell progenitors through deregulated firing of DNA replication origins, with implications for the pathogenesis, genomic instability and treatment of medulloblastoma.

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Fig. 1: Shh regulates DNA replication.

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Authors and Affiliations

  1. Genome Integrity Unit, Danish Cancer Society Research Center, Copenhagen, Denmark

    Apolinar Maya-Mendoza & Jiri Bartek

  2. DNA Replication and Cancer Group, Genome Integrity Unit, Danish Cancer Society Research Center, Copenhagen, Denmark

    Apolinar Maya-Mendoza

  3. Department of Medical Biochemistry and Biophysics, Division of Genome Biology, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden

    Jiri Bartek

Authors
  1. Apolinar Maya-Mendoza
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  2. Jiri Bartek
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Correspondence to Apolinar Maya-Mendoza or Jiri Bartek.

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Maya-Mendoza, A., Bartek, J. Super-sonic speed of DNA synthesis in medulloblastoma. Nat Cancer 1, 758–760 (2020). https://doi.org/10.1038/s43018-020-0105-8

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