Abstract
Organoid technologies enable the creation of in vitro physiologic systems that model tissues of origin more accurately than classical culture approaches. Seminal characteristics of these systems, including three-dimensional structure and recapitulation of self-renewal, differentiation and disease pathology, render organoids eminently suited as hybrids that combine the experimental tractability of traditional two-dimensional cell lines with cellular attributes of in vivo model systems. Here we describe recent advances in this rapidly evolving field and their application to cancer biology, clinical translation and precision medicine.
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Acknowledgements
We thank members of the Kuo lab for discussions and Amanda Mah for figure artwork. This work was supported by US National Institutes of Health fellowship K00CA212433 (Y.-H. L.), a Swedish Research Council International Postdoctoral Fellowship (K. K.), and grants from the NIH (U01CA217851, U54CA224081, U01CA199241 and U19AI116484), Emerson Collective and Ludwig Cancer Research to C. J. K.
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Lo, YH., Karlsson, K. & Kuo, C.J. Applications of organoids for cancer biology and precision medicine. Nat Cancer 1, 761–773 (2020). https://doi.org/10.1038/s43018-020-0102-y
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DOI: https://doi.org/10.1038/s43018-020-0102-y
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