Harnessing the effects of endurance exercise to optimize cognitive health: Fundamental insights from Dr. Mark P. Mattson
Section snippets
Introduction: on your Mark!
The transformation of human societies from preindustrial, to industrial, to postindustrial has been paralleled by changes in the threats to human health and longevity. In this digital era, sedentary lifestyles, limitless supplies of energy-dense nutrient-poor foods, tobacco use, and alcohol abuse are widely recognized for their influence on the pathogenesis of cardiovascular diseases, cancers, respiratory diseases, and diabetes; the major drivers of disability and death amongst older adults.
Final re-Marks
Advances in the biological understanding of aging have led to a search for interventions to delay, prevent, or even cure age-related diseases as a group. Indeed, such therapies would have a transformative impact on human health. Throughout his career, Dr. Mattson has been a vocal champion and a role model for energetic interventions based on lifestyle choices, not pharmacological regimens, that counter the very pillars of aging and, in turn, thwart the diseases and disabilities that compromise
Acknowledgements
The authors acknowledge the support of the National Institutes of Aging, National Institutes of HealthAG053832, AG044170 (NKL) and AG058798 (MJS). Moreover, the authors are grateful for the artwork of Sabrina Brady featured in Fig. 1.
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These authors contributed equally to this work