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O/SEA/Mya-98 lineage foot-and-mouth disease virus was responsible for an extensive epidemic that occurred in late 2018 in Vietnam

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Abstract

Since late 2018, foot-and-mouth disease (FMD) has reemerged and rapidly swept through pig farms in North and Central Vietnam, despite widespread use of commercial FMD vaccines. To investigate the FMD virus (FMDV) strains responsible for the current epidemics, 40 FMDV samples were collected from 17 provinces during November-December 2018, and the VP1 coding genes were sequenced and analyzed. Phylogenetic analysis and sequence comparisons revealed that all of the reemerging Vietnamese FMDVs belonged to the Mya-98 lineage of the O/Southeast Asia topotype (O/SEA/Mya-98) and shared high nucleotide (99.06–100% identity) and amino acid (97.65–100% identity) sequence similarity with each other. The study results suggested that the reemerging FMDVs originated from local Vietnamese strains. Field viruses had different amino acids in the antigenic sites of VP1 when compared to the strains used in the vaccines. The present study provides an important basis for vaccine selection in the battle against FMD in Vietnam.

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Acknowledgments

This research was supported by the Vietnam National University of Agriculture.

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Authors and Affiliations

  1. Faculty of Veterinary Medicine, Vietnam National University of Agriculture, Trau Quy, Gia Lam, Hanoi, Vietnam

    Nguyen Van Diep, Trinh Thi Bich Ngoc, Le Quoc Hoa, Bui Thi To Nga, Nguyen Thi Lan & Van Phan Le

  2. Laboratory of Animal Hygiene, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan

    Nguyen Van Diep

  3. Median Diagnostics, Chuncheon-si, South Korea

    BoKyo Kang & Jinsik Oh

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  1. Nguyen Van Diep
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  2. Trinh Thi Bich Ngoc
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  3. Le Quoc Hoa
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  4. Bui Thi To Nga
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  7. Nguyen Thi Lan
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  8. Van Phan Le
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Correspondence to Van Phan Le.

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Ethical statement

The authors confirm that the ethical policies of the journal, as noted on the journal’s author guidelines page, have been adhered to. The samples were collected from pigs that died on the farms before sampling. Thus, no aggressive intervention toward the pigs was carried out for sampling purposes.

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Van Diep, N., Ngoc, T.T.B., Hoa, L.Q. et al. O/SEA/Mya-98 lineage foot-and-mouth disease virus was responsible for an extensive epidemic that occurred in late 2018 in Vietnam. Arch Virol 165, 2487–2493 (2020). https://doi.org/10.1007/s00705-020-04763-8

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  • DOI: https://doi.org/10.1007/s00705-020-04763-8

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