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Facile preparation of novel Pd nanowire networks on a polyaniline hydrogel for sensitive determination of glucose

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Abstract

In this study, novel Pd nanowire networks (PdNW) grown on three-dimensional polyaniline hydrogel (3D-PANI) were prepared via a facile one-step electrodeposition approach at a constant potential of − 0.2 V and further utilized as an electrochemical sensing material for sensitive determination of glucose in alkaline medium. Compared with the sensor based on Pd nanofilm (PdNF)/3D-PANI prepared by electrodeposition at − 0.9 V, the sensor based on PdNW/3D-PANI presented substantially enhanced electrocatalytic activity towards glucose oxidation, with an excellent sensitivity of 146.6 μA mM−1 cm−2, a linear range from 5.0 to 9800 μM, and a low detection limit of 0.7 μM and was, therefore, demonstrated to be available for the determination of glucose in human serum. These findings are likely attributed to the combination of advantages of both PdNW and 3D-PANI, which outperformed most other Pd-based non-enzymatic glucose sensors reported earlier. Moreover, this non-enzymatic electrochemical sensor based on PdNW/3D-PANI may serve as an alternative tool for the assay of glucose and possibly other biomolecules.

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Acknowledgments

The authors would like to thank Shaanxi Provincial Key Laboratory of Electroanalytical Chemistry (Xi’an, China).

Funding

This work was financially supported by Shaanxi Provincial Key Laboratory of Electroanalytical Chemistry (Xi’an, China). This work was supported by the National Natural Science Foundation of China (No.21575113), the Natural Science Foundation of Shaanxi Province in China (No.2020JQ859, 2019JQ874), Foundation of Education Department of Shaanxi Province (No.20JK0601, 19JK0235), and the Subject Innovation Team of Shaanxi University of Chinese Medicine (No.2019-PY02).

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Authors and Affiliations

  1. College of Pharmacy, Shaanxi Key Laboratory Basic & New Herbal Medicament Research, Shaanxi University of Chinese Medicine, Xianyang, 712046, Shaanxi, China

    Zhi Li, Hui Guo, Xiao Song, Hao Yan & Ruyi Jin

  2. The Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, 712000, Shaanxi, China

    Weina Qian

  3. College of Chemistry and Materials Science, Institute of Analytical Science, Shaanxi Provincial Key Laboratory of Electroanalytical Chemistry, Northwest University, Xi’an, 710069, Shaanxi, China

    Jianbin Zheng

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  1. Zhi Li
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Li, Z., Qian, W., Guo, H. et al. Facile preparation of novel Pd nanowire networks on a polyaniline hydrogel for sensitive determination of glucose. Anal Bioanal Chem 412, 6849–6858 (2020). https://doi.org/10.1007/s00216-020-02816-0

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