Abstract
A concise synthetic strategy has been developed for the synthesis of the pentasaccharide repeating unit of the cell wall O-antigen of Escherichia coli O43 strain involving stereoselective β-D-mannosylation and α-L-fucosylation using corresponding trichloroacetimidate intermediates and perchloric acid supported over silica (HClO4-SiO2) as glycosylation promoter. The yield and stereoselectivity of the glycosylations were very good.
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P. S. thanks CSIR, New Delhi for providing Senior Research Fellowship. The work is supported by SERB, India (Project No. CRG/2019/000352 dated 23.01.2020) (AKM) and Bose Institute.
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Shit, P., Misra, A.K. Straightforward synthesis of the pentasaccharide repeating unit of the cell wall O-antigen of Escherichia coli O43 strain. Glycoconj J 37, 647–656 (2020). https://doi.org/10.1007/s10719-020-09933-z
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DOI: https://doi.org/10.1007/s10719-020-09933-z