Reviews: Current TopicsAnti-inflammatory activities of green tea catechins along the gut–liver axis in nonalcoholic fatty liver disease: lessons learned from preclinical and human studies☆,☆☆
Abbreviations
ALT
alanine aminotransferase
AST
aspartate aminotransferase
CAT
catechins
EC
epicatechin
ECG
epicatechin gallate
EGC
epigallocatechin
EGCG
epigallocatechin gallate
FITC
fluorescein isothiocyanate
GSH
glutathione
GTE
green tea extract
HF
high-fat
HIF-1α
hypoxia inducible factor-1α
IΚΚ
IκB kinase
IκB
inhibitor of NFκB
iNOS
inducible nitric oxide synthase
LPS
lipopolysaccharides
MCD
methionine- and choline-deficient
MCP-1
monocyte chemoattractant protein-1
MyD88
myeloid differentiation primary response gene-88
NAFLD
nonalcoholic fatty liver disease
NASH
nonalcoholic steatohepatitis
NEFAs
non-esterified fatty acids
NFκB
nuclear factor kappa-B
Nrf2
nuclear factor erythroid 2-related factor-2
ROS
reactive oxygen species
TJPs
tight junction proteins
TLR4
Toll-like receptor-4
TNFα
tumor necrosis factor-α
TNFR
tumor necrosis factor-α receptor
TRIF
TIR-domain-containing adapter-inducing interferon-β
VL
valerolactones
WT
wild-type
Keywords
Green tea catechins
Nonalcoholic steatohepatitis
Inflammation
Metabolic endotoxemia
Gut dysbiosis
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Support was provided by grants to RSB from USDA-NIFA (2019-67017-29259), the Center for Applied Plant Sciences at The Ohio State University, USDA-HATCH (OHO01452-MRF), and the Ohio Agricultural Research and Development Center at The Ohio State University.
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The authors declare no conflicts of interest.
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