Issue 1, 2021
From the journal:

Natural Product Reports

Cytotoxic and antitumor peptides as novel chemotherapeutics

Xin Luan,†a   Ye Wu,†a   Yi-Wen Shen,a   Hong Zhang,a   Yu-Dong Zhou,ab   Hong-Zhuan Chen,a   Dale G. Nagle*ac  and  Wei-Dong Zhang ORCID logo *ad  

* Corresponding authors

a Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China

b Department of Chemistry and Biochemistry, College of Liberal Arts, University of Mississippi, University-1848, MS, USA

c Department of BioMolecular Sciences and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University-1848, MS 38677, USA
E-mail: dnagle@olemiss.edu

d School of Pharmacy, Second Military Medical University, Shanghai, China
E-mail: wdzhangy@hotmail.com

Abstract

Covering: up to 2020

Treatment resistance and drug-induced refractory malignancies pose significant challenges for current chemotherapy drugs. There have been increasing research efforts aimed at developing novel chemotherapeutics, especially from natural products and related derivatives. Natural cytotoxic peptides, an emerging source of chemotherapeutics, have exhibited the advantage of overcoming drug resistance and displayed broad-spectrum antitumor activities in the clinic. This highlight examines the increasingly popular cytotoxic peptides from isolated natural products. In-depth review of several peptides provides examples for how this novel strategy can lead to the improved anti-tumor effects. The mechanisms and current application of representative natural cytotoxic peptides (NCPs) have also been discussed, with a particular focus on future directions for interdisciplinary research.

Graphical abstract: Cytotoxic and antitumor peptides as novel chemotherapeutics

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Article information

DOI
https://doi.org/10.1039/D0NP00019A
Article type
Highlight
Submitted
22 Apr 2020
First published
10 Aug 2020

Nat. Prod. Rep., 2021,38, 7-17

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Cytotoxic and antitumor peptides as novel chemotherapeutics

X. Luan, Y. Wu, Y. Shen, H. Zhang, Y. Zhou, H. Chen, D. G. Nagle and W. Zhang, Nat. Prod. Rep., 2021, 38, 7 DOI: 10.1039/D0NP00019A

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