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5-Fluorouracil Trapping in a Porous Ba(II)-organic Framework: Drug Delivery and Anti-thyroid Cancer Activity Evaluation

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Abstract

Solvothermal treatment of Ba(NO3)2 with the rigid tricarboxylic acid linker 4,4′,4″-s-triazine-2,4,6-triyltribenzoic acid (H3TATB) in a mixture of H2O and N,N-dimethylformamide (DMF) produces a new three-dimensional porous metal-organic framework having the chemical formula of [Ba(HTATB)-(H2O)2](DMF)4 (I). The complex I has been characterized by powder X-ray diffraction, elemental analysis and single crystal X-ray diffraction (CIF file CCDC no. 1898532). In light of its large inner spaces as well as widely distributed open metal sites, the guest-free I (Ia) has been used as a crystalline vessel for trapping the anticancer drug 5-fluorouracil (5-FU), which has been investigated both experimentally and computationally. Furthermore, MTT assay was employed to evaluate the in vitro cytotoxicity of the carrier 5-FU loaded Ia against the human thyroid cancer cell lines.

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Authors and Affiliations

  1. Department of General Surgery, Xuzhou Central Hospital, Xuzhou, Jiangsu, China

    Q. J. Zhang, J. K. Zhao, Y. Li, X. Y. Wu, L. L. Ma & Z. M. Ding

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  1. Q. J. Zhang
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  2. J. K. Zhao
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  3. Y. Li
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  4. X. Y. Wu
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  5. L. L. Ma
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  6. Z. M. Ding
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Correspondence to Z. M. Ding.

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Zhang, Q.J., Zhao, J.K., Li, Y. et al. 5-Fluorouracil Trapping in a Porous Ba(II)-organic Framework: Drug Delivery and Anti-thyroid Cancer Activity Evaluation. Russ J Coord Chem 46, 584–591 (2020). https://doi.org/10.1134/S1070328420080072

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  • DOI: https://doi.org/10.1134/S1070328420080072

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