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Small-sized deformable hollow mesoporous organosilica nanocapsules with improved cellular uptake

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Abstract

The application of nanomaterials in biomedical fields is greatly influenced by their properties such as size, morphology, and surface properties. The deformability of nanomaterials in recently found influence the blood circulation, pharmacokinetics, tumor accumulation, and treatment performance for diseases. In the work, we successfully fabricated small-sized deformable mesoporous organosilica nanocapsules (SDMONC) via a preferential etching approach. To synthesize the SDMONC, a series of small mesostructured organosilica nanoparticles (MONs) are prepared by adjusting the concentrations of cetyltrimethylammonium bromide (CTAB). After etching the interiors of the MONs with NaOH, small-sized SDMONC with diameters ranging from 70 to 156 nm are obtained. The prepared SDMONC have uniform diameter, high specific surface area (266 m2 g−1), uniform pore diameter (4.0 nm), and excellent biocompability. The cellular uptake of the SDMONC was investigated, which exhibited higher cellular uptake efficiency and cancer cell-killing efficiency than the nondeformable nanoparticles, showing great promise for biomedical applications.

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Acknowledgements

This investigation was supported by the Jiangsu Province Natural Science Foundation (Grant Nos. BK20130969, BK20160017), the National Natural Science Foundation of China (Grant Nos. 81971675, 21603106), and the Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals.

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Authors and Affiliations

  1. College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037, People’s Republic of China

    Xu Peng & Qing Wang

  2. Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing, 210046, Jiangsu, People’s Republic of China

    Xiaodan Su, Jun Tao, Zhihao Feng & Zhaogang Teng

  3. Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, 100193, People’s Republic of China

    Hongru Zhang

  4. College of Chemistry & Chemical Engineering, Northeast Petroleum University, Daqing, 163318, People’s Republic of China

    Weiguang Shi

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  1. Xu Peng
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  2. Qing Wang
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  3. Hongru Zhang
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  4. Xiaodan Su
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  8. Zhaogang Teng
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Correspondence to Zhaogang Teng.

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Peng, X., Wang, Q., Zhang, H. et al. Small-sized deformable hollow mesoporous organosilica nanocapsules with improved cellular uptake. J Porous Mater 27, 1783–1789 (2020). https://doi.org/10.1007/s10934-020-00953-6

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