Microcavity array supported lipid bilayer models of ganglioside – influenza hemagglutinin1 binding

Guilherme B. Berselli; Nirod Kumar Sarangi; Aurélien V. Gimenez; Paul V. Murphy; Tia E. Keyes

doi:10.1039/D0CC04276E

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Microcavity array supported lipid bilayer models of ganglioside – influenza hemagglutinin₁ binding†

Guilherme B. Berselli,

‡^a Nirod Kumar Sarangi,

‡^a Aurélien V. Gimenez,^a Paul V. Murphy

^b and Tia E. Keyes

*^a

Author affiliations

* Corresponding authors

^a School of Chemical Sciences, Dublin City University, Dublin, Ireland
E-mail: tia.keyes@dcu.ie

^b School of Chemistry NUI Galway University Road, Galway, Ireland

Abstract

The binding of influenza receptor (HA₁) to membranes containing different glycosphingolipid receptors was investigated at Microcavity Supported Lipid Bilayers (MSLBs). We observed that HA₁ preferentially binds to GD1a but the diffusion coefficient of the associated complex at lipid bilayer is approximately double that of the complexes formed by HA₁ GM1 or GM3.

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Article information

DOI: https://doi.org/10.1039/D0CC04276E
Article type: Communication
Submitted: 19 Jun 2020
Accepted: 07 Aug 2020
First published: 07 Aug 2020

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Chem. Commun., 2020,56, 11251-11254

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Microcavity array supported lipid bilayer models of ganglioside – influenza hemagglutinin₁ binding

G. B. Berselli, N. K. Sarangi, A. V. Gimenez, P. V. Murphy and T. E. Keyes, Chem. Commun., 2020, 56, 11251 DOI: 10.1039/D0CC04276E

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