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Abnormalities in hemispheric lateralization of intra- and inter-hemispheric white matter connections in schizophrenia

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Abstract

Hemispheric lateralization is a prominent feature of the human brain and is grounded into intra- and inter-hemispheric white matter (WM) connections. However, disruptions in hemispheric lateralization involving both intra- and inter-hemispheric WM connections in schizophrenia is still unclear. Hence, a quantitative measure of the hemispheric lateralization of intra- and inter-hemispheric WM connections could provide new insights into schizophrenia. This work performed diffusion tensor imaging on 50 patients and 58 matched healthy controls. Using graph theory, the global and nodal efficiencies were computed for both intra- and inter-hemispheric networks. We found that patients with schizophrenia showed significantly decrease in both global and nodal efficiency of hemispheric networks relative to healthy controls. Specially, deficits in intra-hemispheric integration and inter-hemispheric communication were revealed in frontal and temporal regions for schizophrenia. We also found disrupted hemispheric asymmetries in brain regions associated with emotion, memory, and visual processes for schizophrenia. Moreover, abnormal hemispheric asymmetry of nodal efficiency was significantly correlated with the symptom of the patients. Our finding indicated that the hemispheric WM lateralization of intra- and inter-hemispheric connections could serve as a potential imaging biomarker for schizophrenia.

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Acknowledgments

The authors would like to thank the Institutional Review Board of the University of California, Los Angeles Study team for making the dataset available OpenfMRI. Funding for this research was provided the National Natural Science Foundation of China (Grants No. 61906130).

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Authors and Affiliations

  1. College of Information and Computer, Taiyuan University of Technology, Shanxi, China

    Dandan Li, Nan Zhang, Jie Xiang, Yan Niu & Bin Wang

  2. School of Mechanical, Electrical and Information Engineering, Shandong University at Weihai, Shandong, China

    Wenjing Tang

  3. Translational Medicine Research Center, Shanxi Medical University, Shanxi, China

    Ting Yan & Bin Wang

Authors
  1. Dandan Li
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  2. Wenjing Tang
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  3. Ting Yan
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  4. Nan Zhang
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  5. Jie Xiang
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  6. Yan Niu
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  7. Bin Wang
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Corresponding author

Correspondence to Bin Wang.

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The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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The study was carried out in strict accordance with the University of California, Los Angeles Institutional Review Board.

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After receiving a thorough explanation, all participants gave written informed consent according to the procedures approved by the University of California Los Angeles Institutional Review Board.

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Li, D., Tang, W., Yan, T. et al. Abnormalities in hemispheric lateralization of intra- and inter-hemispheric white matter connections in schizophrenia. Brain Imaging and Behavior 15, 819–832 (2021). https://doi.org/10.1007/s11682-020-00292-9

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