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Non-coding RNAS and colorectal cancer liver metastasis

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Abstract

More than 50% of colorectal cancer (CRC) deaths are attributed to metastasis, and the liver is the most common distant metastatic site of CRC. The molecular mechanisms underlying CRC liver metastasis are very complicated and remain largely unknown. Accumulated evidence has shown that non-coding RNAs (NcRNAs) play critical roles in tumor development and progression. Here we reviewed the roles and underlying mechanisms of NcRNAs in CRC liver metastasis.

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Funding

This work was supported by grants from the National Natural Science Foundation of China (Grant No. 81572424), Natural Science Foundation of Guangdong Province (Grant No. 2017A030313482), Guangzhou Municipal Science and Technology Project (Grant No. 201607010164), Scientific Research Project of Guangzhou Municipal Colleges and Universities (Grant No. 1201610322).

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  1. Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, People’s Republic of China

    Xiao-Yu Zhou, Bing Luo, Ze-Kun Jiang, Ying-Kang Xie, Feng-Cong Wu, Jiong-Qiang Huang & Jing-Song Chen

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X-YZ finished the manuscript and abstract; BL and Z-KJ consulted relevant literatures and completed English revision; Y-KX and F-CW completed the figures and tables; J-QH provided constructive feedback and guidance; J-SC completed critical revisions and proofread the manuscript. All authors have read and approved the final manuscript.

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Zhou, XY., Luo, B., Jiang, ZK. et al. Non-coding RNAS and colorectal cancer liver metastasis. Mol Cell Biochem 475, 151–159 (2020). https://doi.org/10.1007/s11010-020-03867-8

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