Skip to main content

Advertisement

SpringerLink
Log in

A Zn(II)-MOF with Suitable Pore Surroundings for Cyanosilylation Reaction and Protective Effect on Bladder Cancer Cells by Regulating miR-130 and CYLD

  • Published:
Journal of Inorganic and Organometallic Polymers and Materials Aims and scope Submit manuscript

Abstract

A porous metal–organic framework (MOF) based on Zn(II) metal nodes was prepared via reaction of rigid V-shaped ligand 2,6-di(2′,5′-dicarboxylphenyl)pyridine (H4L) along with Zn(NO3)2·6H2O in water and DMF mixed solvent, and its chemical formula was [Zn3(L)(OH)2(H2O)4](DMF)5 (1). The results show that the obtained activated 1a has catalytic activity for aromatic aldehydes cyanation under the existence of the trimethylsilyl cyanide, thus providing trimethylsilyl cyanohydrin in the form of shape along with size selection. In addition, a feasible synergistic mechanism of 1a for cyanosilylation of aldehyde also has been put forward. Furthermore, the treatment function of the compound on bladder cancer cells was assessed. The reverse transcription-polymerase chain reaction (PT-PCR) was carried out to determine cyclindromatosis (CYLD) and miR-130 relative expression in bladder cancer cells after the combine therapy. Besides, the mechanism of the compound was explored, by evaluating the level of autophagic programed cell death by western blot.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Scheme 1
Fig. 3
Fig. 4

Similar content being viewed by others

Data Availability

The data used to support the findings of this study are included within the article.

References

  1. R.H.M. Rodriguez, O.B. Rueda, L. Ibarz, Med. Clin. 149, 449–455 (2017)

    Article  Google Scholar 

  2. Y. Yang, K. Takahara, T. Kumrungsee, A. Kimoto, F. Shimamoto, N. Kato, J. Nutr. Sci. Vitaminol. 65, 443–450 (2019)

    Article  CAS  Google Scholar 

  3. J. Wen, X. Liu, Y. Qi, F. Niu, Z. Niu, W. Geng, Z. Zou, R. Huang, J. Wang, H. Zou, J. Exp. Clin. Cancer Res. 38, 428 (2019)

    Article  Google Scholar 

  4. Y. Xi, P. Yuefen, W. Wei, Q. Quan, Z. Jing, X. Jiamin, H. Shuwen, J. Transl. Med. 17, 353 (2019)

    Article  Google Scholar 

  5. X. Feng, J. Liu, J. Li, L.F. Ma, L.Y. Wang, S.W. Ng, G.Z. Qin, J. Solid State Chem. 230, 80–89 (2015)

    Article  CAS  Google Scholar 

  6. W. Li, S. Hu, X. Luo, Z. Li, X. Sun, M. Li, F. Liu, Y. Yu, Adv. Mater. 29, 1605820 (2017)

    Article  Google Scholar 

  7. X. Feng, J.L. Chen, R.F. Bai, L.Y. Wang, J.T. Wei, X.X. Chen, Inorg. Chem. Commun. 66, 41–46 (2016)

    Article  CAS  Google Scholar 

  8. C. Duan, Y. Yu, J. Xiao, X. Zhang, L. Li, P. Yang, J. Wu, H. Xi, Sci. China Mater. 63, 667–685 (2020)

    Article  Google Scholar 

  9. H. Du, C. Ma, W. Ma, H. Wang, Process. Appl. Ceram. 12, 303–312 (2018)

    Article  CAS  Google Scholar 

  10. X. Feng, N. Guo, H.P. Chen, H.L. Wang, L.Y. Yue, X. Chen, S.W. Ng, X.F. Liu, L.F. Ma, L.Y. Wang, Dalton Trans. 46, 14192–14200 (2017)

    Article  CAS  Google Scholar 

  11. M. Arshad, H.L. Du, M.S. Javed, A. Maqsood, I. Ashraf, S. Hussain, W.L. Ma, H.P. Ran, Ceram. Int. 46, 2238–2246 (2020)

    Article  CAS  Google Scholar 

  12. X. Feng, Y.Q. Feng, N. Guo, Y.L. Sun, T. Zhang, L.F. Ma, L.Y. Wang, Inorg. Chem. 56, 1713–1721 (2017)

    Article  CAS  Google Scholar 

  13. D. Wang, B. Liu, S. Yao, T. Wang, G. Li, Q. Huo, Y. Liu, Chem. Commun. 51, 15287–15289 (2015)

    Article  CAS  Google Scholar 

  14. S.B. Choi, H. Furukawa, H.J. Nam, D.Y. Jung, Y.H. Jhon, A. Walton, D. Book, M. O’Keeffe, O.M. Yaghi, J. Kim, Angew. Chem. Int. Ed. 51, 8791–8795 (2012)

    Article  CAS  Google Scholar 

  15. C.D.S. Cadiau, P.M.F.J. Brites, R.A.S. Costa, J. Ferreira, L.D. Rocha, Carlos. ACS Nano 7, 7213–7218 (2013)

    Article  CAS  Google Scholar 

  16. D.M. Chen, X.J. Zhang, CrystEngComm 21, 4696–4700 (2019)

    Article  CAS  Google Scholar 

  17. A. Karmakar, A. Paul, G.M.D.M. Rúbio, M.F.C. Guedes da Silva, A.J.L. Pombeiro, Eur. J. Inorg. Chem. 2016, 5557–5567 (2016)

    Article  CAS  Google Scholar 

  18. F.G. Xi, Y. Yang, H. Liu, H.F. Yao, E.Q. Gao, RSC Adv. 5, 79216–79223 (2015)

    Article  CAS  Google Scholar 

  19. J. Li, Y. Ren, C. Qi, H. Jiang, Chem. Commun. 53, 8223–8226 (2017)

    Article  CAS  Google Scholar 

  20. D.M. Chen, X.J. Zhang, J. Solid State Chem. 278, 120906 (2019)

    Article  CAS  Google Scholar 

  21. R.S. Wang, J. Feng, Y.Z. Lei, D.M. Chen, M.L. Lian, Cryst. Res. Technol. 53, 1800065 (2018)

    Article  Google Scholar 

  22. B. Fernández, I. Fernández, J. Cepeda, M. Medina-O’Donnell, E.E. Rufino-Palomares, Á. Raya-Barón, S. Gómez-Ruiz, A. Pérez-Jiménez, J.A. Lupiáñez, F.J. Reyes-Zurita, A. Rodríguez-Diéguez, Cryst. Growth Des. 18, 969–978 (2018)

    Article  Google Scholar 

  23. D.S. Raja, N.S.P. Bhuvanesh, K. Natarajan, Dalton Trans. 41, 4365–4377 (2012)

    Article  CAS  Google Scholar 

  24. K. Wang, X. Ma, D. Shao, Z. Geng, Z. Zhang, Z. Wang, Cryst. Growth Des. 12, 3786–3791 (2012)

    Article  CAS  Google Scholar 

  25. S. Mukherjee, S. Ganguly, K. Manna, S. Mondal, S. Mahapatra, D. Das, Inorg. Chem. 57, 4050–4060 (2018)

    Article  CAS  Google Scholar 

  26. N. Chen, M.X. Li, P. Yang, X. He, M. Shao, S.R. Zhu, Cryst. Growth Des. 13, 2650–2660 (2013)

    Article  CAS  Google Scholar 

  27. M.Y. Sun, D.M. Chen, Polyhedron 147, 80–85 (2018)

    Article  CAS  Google Scholar 

  28. X. Cui, M.C. Xu, L.J. Zhang, R.X. Yao, X.M. Zhang, Dalt. Trans. 44, 12711–12716 (2015)

    Article  CAS  Google Scholar 

  29. A. Bhunia, S. Dey, J.M. Moreno, U. Diaz, P. Concepcion, K. Van Hecke, C. Janiak, P. Van Der Voort, Chem. Commun. 52, 1401–1404 (2016)

    Article  CAS  Google Scholar 

  30. J.J. Du, X. Zhang, X.P. Zhou, D. Li, Inorg. Chem. Front. 5, 2772–2776 (2018)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Urology, The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China

    Yu-Ye Wu, Hai-Qing Fan, Hui-Jun Chen, Li-Xing Jiang & Wei-Ping Zhang

Authors
  1. Yu-Ye Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hai-Qing Fan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hui-Jun Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Li-Xing Jiang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Wei-Ping Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Wei-Ping Zhang.

Ethics declarations

Conflicts of interest

The author(s) declare(s) that there is no conflict of interest regarding the publication of this paper.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wu, YY., Fan, HQ., Chen, HJ. et al. A Zn(II)-MOF with Suitable Pore Surroundings for Cyanosilylation Reaction and Protective Effect on Bladder Cancer Cells by Regulating miR-130 and CYLD. J Inorg Organomet Polym 31, 520–527 (2021). https://doi.org/10.1007/s10904-020-01694-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10904-020-01694-4

Keywords

Search

Navigation