Gas-mediated cancer therapy

Review
Published: 07 August 2020

Volume 19, pages 149–166, (2021)
Cite this article

Environmental Chemistry Letters Aims and scope Submit manuscript

Hang Zhang¹,
Mengying Xie²,
Honghong Chen¹,
Sneha Bavi³,
Muhammad Sohail⁴ &
…
Rohit Bavi ORCID: orcid.org/0000-0003-3167-4131^1,5

1960 Accesses
16 Citations
Explore all metrics

Abstract

Gas therapy is actually drawing attention in nanomedicine as a safe and therapeutically efficient technique. Indeed, the design of stimuli-responsive nanocarriers with controlled release is encouraging to heal without any risk of gas poisoning. Here, we review recent developments of gas nanogenerators and gas-releasing molecules for controlled and targeted gas therapy in cancer nanomedicine. We present gases used in anticancer therapy, such as hydrogen, carbon dioxide, sulfur dioxide, hydrogen sulfide, oxygen, carbon monoxide, and heavy gases. The construction of gas nanogenerators and gas-releasing molecules with unique biological and physicochemical properties has allowed targeted and controlled release of gas molecules. We describe the stimulation method for each gas, along with gas nanogenerators and gas-releasing molecules.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Fig. 2

Fig. 3

Fig. 4

Fig. 5

Fig. 6

Similar content being viewed by others

Near-infrared light-triggered nano-prodrug for cancer gas therapy

Article Open access 23 December 2021

Recent deveolpment of multifunctional responsive gas-releasing nanoplatforms for tumor therapeutic application

Article 28 May 2022

Gas-mediated cancer therapy combined with starvation therapy, ultrasound therapy, chemotherapy, radiotherapy, and photodynamic therapy: a review

Article 24 March 2021

References

Bathoorn E, Slebos D-J, Postma DS, Koeter GH, van Oosterhout AJM, van der Toorn M, Boezen HM, Kerstjens HAM (2007) Anti-inflammatory effects of inhaled carbon monoxide in patients with COPD: a pilot study. Eur Respir J 30:1131–1137. https://doi.org/10.1183/09031936.00163206
Article CAS Google Scholar
Botov S, Stamellou E, Romanski S, Guttentag M, Alberto R, Neudörfl J-M, Yard B, Schmalz H-G (2013) Synthesis and performance of acyloxy-diene-Fe(CO)₃ complexes with variable chain lengths as enzyme-triggered carbon monoxide-releasing molecules. Organometallics 32:3587–3594. https://doi.org/10.1021/om301233h
Article CAS Google Scholar
Chakraborty I, Carrington SJ, Mascharak PK (2014) Design strategies to improve the sensitivity of photoactive metal carbonyl complexes (photoCORMs) to visible light and their potential as CO-donors to biological targets. Acc Chem Res 47:2603–2611. https://doi.org/10.1021/ar500172f
Article CAS Google Scholar
Chakraborty I, Carrington SJ, Hauser J, Oliver SR, Mascharak PK (2015) Rapid eradication of human breast cancer cells through trackable light-triggered CO delivery by mesoporous silica nanoparticles packed with a designed photocorm. Chem Mater 27:8387–8397. https://doi.org/10.1021/acs.chemmater.5b03859
Article CAS Google Scholar
Chaves-Ferreira M, Albuquerque IS, Matak-Vinkovic D, Coelho AC, Carvalho SM, Saraiva LM, Romaõ CC, Bernardes GJL (2015) Spontaneous CO release from RuII(CO)₂-protein complexes in aqueous solution, cells, and Mice. Angew Chem 127:1188–1191. https://doi.org/10.1002/anie.201409344
Article CAS Google Scholar
Chen KJ, Liang HF, Chen HL, Wang Y, Cheng PY, Liu HL, Xia Y, Sung HW (2013) A thermoresponsive bubble-generating liposomal system for triggering localized extracellular drug delivery. ACS Nano 7:438–446. https://doi.org/10.1021/nn304474j
Article CAS Google Scholar
Chen KJ, Chaung EY, Wey SP, Lin KJ, Cheng F, Lin CC, Liu HL, Tseng HW, Liu CP, Wei MC, Liu CM, Sung HW (2014) Hyperthermia-mediated local drug delivery by a bubble-generating liposomal system for tumor-specific chemotherapy. ACS Nano 8:5105–5115. https://doi.org/10.1021/nn501162x
Article CAS Google Scholar
Chen H, Tian J, He W, Guo Z (2015a) H₂O₂-activatable and O₂-evolving nanoparticles for highly efficient and selective photodynamic therapy against hypoxic tumor cells. J Am Chem Soc 137:1539–1547. https://doi.org/10.1021/ja511420n
Article CAS Google Scholar
Chen W, Chen M, Zang Q, Wang L, Tang F, Han Y, Yang C, Deng L, Liu YN (2015b) NIR light controlled release of caged hydrogen sulfide based on upconversion nanoparticles. Chem Commun 51:9193–9196. https://doi.org/10.1039/C5CC02508G
Article CAS Google Scholar
Chen J, Luo H, Liu Y, Zhang W, Li H, Luo T, Zhang K, Zhao Y, Liu J (2017) Oxygen-self-produced nanoplatform for relieving hypoxia and breaking resistance to sonodynamic treatment of pancreatic cancer. ACS Nano 11:12849–12862. https://doi.org/10.1021/acsnano.7b08225
Article CAS Google Scholar
Chen YL, Liu FQ, Guo Y, Cheng J, Yang L, Lu M, Li P, Xu J, Yu T, Wang ZG, Cao Y, Ran HT (2018) PA/US Dual-modality imaging to guide VEGFR-2 targeted photothermal therapy using Znpc-/PFH-loaded polymeric nanoparticles. Biomater Sci 6:2130–2143. https://doi.org/10.1039/C8BM00213D
Article CAS Google Scholar
Chen L, Zhou SF, Su L, Song J (2019) Gas-mediated cancer bioimaging and therapy. ACS Nano 13:10887–10917. https://doi.org/10.1021/acsnano.9b04954
Article CAS Google Scholar
Cheng Y, Cheng H, Jiang C, Qiu X, Wang K, Huan W, Yuan A, Wu J, Hu Y (2015) Perfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy. Nat Commun 6:8785. https://doi.org/10.1038/ncomms9785
Article CAS Google Scholar
Cheng H, Zhu JY, Li SY, Zeng JY, Lei Q, Chen KW, Zhang C, Zhang XZ (2016) An O₂ self-sufficient biomimetic nanoplatform for highly specific and efficient photodynamic therapy. Adv Funct Mater 26:7847–7860. https://doi.org/10.1002/adfm.201603212
Article CAS Google Scholar
Chuang EY, Lin CC, Chen KJ, Wan DH, Lin KJ, Ho YC, Lin PY, Sung HW (2016) A FRET-guided, NIR-responsive bubble-generating liposomal system for in vivo targeted therapy with spatially and temporally precise controlled release. Biomaterials 93:48–59. https://doi.org/10.1016/j.biomaterials.2016.03.040
Article CAS Google Scholar
Chung MF, Chen KJ, Liang HF, Liao ZX, Chia WT, Xia Y, Sung HW (2012) A liposomal system capable of generating CO₂ bubbles to induce transient cavitation, lysosomal rupturing, and cell necrosis. Angew Chem Int Ed 51:10089–10093. https://doi.org/10.1002/anie.201205482
Article CAS Google Scholar
Chung MF, Chia WT, Wan WL, Lin YJ, Sung HW (2015) Controlled release of an anti-inflammatory drug using an ultrasensitive ROS-responsive gas-generating carrier for localized inflammation inhibition. J Am Chem Soc 137:12462–12465. https://doi.org/10.1021/jacs.5b08057
Article CAS Google Scholar
Day JJ, Yang Z, Chen W, Pacheco A, Xian M (2016) Benzothiazole sulfinate: a water-soluble and slow-releasing sulfur dioxide donor. ACS Chem Biol 11:1647–1651. https://doi.org/10.1021/acschembio.6b00106
Article CAS Google Scholar
Deng Y, Jia F, Chen S, Shen Z, Jin Q, Fu G, Ji J (2018) Nitric oxide as an all-rounder for enhanced photodynamic therapy: hypoxia relief, glutathione depletion and reactive nitrogen species generation. Biomaterials 187:55–65. https://doi.org/10.1016/j.biomaterials.2018.09.043
Article CAS Google Scholar
Devarie-Baez NO, Bagdon PE, Peng B, Zhao Y, Park C-M, Xian M (2013) Light-induced hydrogen sulfide release from “caged” gem-dithiols. Org Lett 15:2786–2789. https://doi.org/10.1021/ol401118k
Article CAS Google Scholar
Diring S, Carné-Sánchez A, Zhang J, Ikemura S, Kim C, Inaba H, Kitagawa S, Furukawa S (2017) Light responsive metal–organic frameworks as controllable CO-releasing cell culture substrates. Chem Sci 8:2381–2386. https://doi.org/10.1039/C6SC04824B
Article CAS Google Scholar
Eto K, Asada T, Arima K, Makifuchi T, Kimura H (2002) Brain hydrogen sulfide is severely decreased in Alzheimer’s disease. Biochem Biophys Res Commun 293:1485–1488. https://doi.org/10.1016/S0006-291X(02)00422-9
Article CAS Google Scholar
Fan W, Bu W, Zhang Z, Shen B, Zhang H, He Q, Ni D, Cui Z, Zhao K, Bu J, Du J, Liu J, Shi J (2015) X-Ray radiation-controlled NO-release for on-demand depth-independent hypoxic radiosensitization. Angew Chem Int Ed 54:14026–14030. https://doi.org/10.1002/anie.201504536
Article CAS Google Scholar
Feng Q, Zhang W, Yang X, Li Y, Hao Y, Zhang H, Hou L, Zhang Z (2018) pH/Ultrasound dual-responsive gas generator for ultrasound imaging-guided therapeutic inertial cavitation and sonodynamic therapy. Adv Healthc Mater 7:1700957. https://doi.org/10.1002/adhm.201700957
Article CAS Google Scholar
Fix SM, Borden MA, Dayton PA (2015) Therapeutic gas delivery via microbubbles and liposomes. J Controll Release 209:139–149. https://doi.org/10.1016/j.jconrel.2015.04.027
Article CAS Google Scholar
Foster JC, Radzinski SC, Zou X, Finkielstein CV, Matson JB (2017) H₂S-releasing polymer micelles for studying selective cell toxicity. Mol Pharm 14:1300–1306. https://doi.org/10.1021/acs.molpharmaceut.6b01117
Article CAS Google Scholar
Frederiksen LJ, Sullivan R, Maxwell LR, Macdonald-Goodfellow SK, Adams MA, Bennett BM, Siemens DR, Graham CH (2007) Chemosensitization of cancer in vitro and in vivo by nitric oxide signaling. Clin Cancer Res 13:2199–2206. https://doi.org/10.1158/1078-0432.ccr-06-1807
Article CAS Google Scholar
Fujita K, Tanaka Y, Sho T, Ozeki S, Abe S, Hikage T, Kuchimaru T, Kizaka-Kondoh S, Ueno T (2014) Intracellular CO release from composite of ferritin and ruthenium carbonyl complexes. J Am Chem Soc 136:16902–16908. https://doi.org/10.1021/ja508938f
Article CAS Google Scholar
Fujita K, Tanaka Y, Abe S, Ueno T (2016) A photoactive carbon-monoxide-releasing protein cage for dose-regulated delivery in living cells. Angew Chem Int Ed 55:1056–1060. https://doi.org/10.1002/anie.201506738
Article CAS Google Scholar
Fukushima N, Ieda N, Sasakura K, Nagano T, Hanaoka K, Suzuki T, Miyata N, Nakagawa H (2014) Synthesis of a photocontrollable hydrogen sulfide donor using ketoprofenate photocages. Chem Commun 50:587–589. https://doi.org/10.1039/C3CC47421F
Article CAS Google Scholar
Gao W, Li SS, Liu ZH, Sun YH, Cao WH, Tong LL, Cui GW, Tang B (2017) Targeting and destroying tumor vasculature with a near-infrared laser-activated “nanobomb” for efficient tumor ablation. Biomaterials 139:1–11. https://doi.org/10.1016/j.biomaterials.2017.05.037
Article CAS Google Scholar
Gao C, Liang X, Guo Z, Jiang BP, Liu X, Shen XC (2018a) Diiron hexacarbonyl complex induces site-specific release of carbon monoxide in cancer cells triggered by endogenous glutathione. ACS Omega 3:2683–2689. https://doi.org/10.1021/acsomega.8b00052
Article CAS Google Scholar
Gao S, Zheng P, Li Z, Feng X, Yan W, Chen S, Guo W, Liu D, Yang X, Wang S et al (2018b) Biomimetic O₂-evolving metal–organic framework nanoplatform for highly efficient photodynamic therapy against hypoxic tumor. Biomaterials 178:83–94. https://doi.org/10.1016/j.biomaterials.2018.06.007
Article CAS Google Scholar
Ge L, Yang M, Yang NN, Yin XX, Song WG (2017) Molecular hydrogen: a preventive and therapeutic medical gas for various diseases. Oncotarget 8:102653–102673. https://doi.org/10.18632/oncotarget.21130
Article Google Scholar
Govender P, Pai S, Schatzschneider U, Smith GS (2013) Next generation photocorms: polynuclear tricarbonylmanganese(I)-functionalized polypyridyl metallodendrimers. Inorg Chem 52:5470–5478. https://doi.org/10.1021/ic400377k
Article CAS Google Scholar
Guo F, Yu M, Wang J, Tan F, Li N (2015) Smart IR780 theranostic nanocarrier for tumor-specific therapy: hyperthermia-mediated bubble-generating and folate-targeted liposomes. ACS Appl Mater Interfaces 7:20556–20567. https://doi.org/10.1021/acsami.5b06552
Article CAS Google Scholar
Hasegawa U, van der Vlies AJ, Simeoni E, Wandrey C, Hubbell JA (2010) Carbon monoxide-releasing micelles for immunotherapy. J Am Chem Soc 132:18273–18280. https://doi.org/10.1021/ja1075025
Article CAS Google Scholar
He Q (2017) Precision gas therapy using intelligent nanomedicine. Biomater Sci 5:2226–2230. https://doi.org/10.1039/C7BM00699C
Article CAS Google Scholar
He Q, Kiesewetter DO, Qu Y, Fu X, Fan J, Huang P, Liu Y, Zhu G, Liu Y, Qian Z et al (2015) NIR-responsive on-demand release of CO from metal carbonyl-caged graphene oxide nanomedicine. Adv Mater 27:6741–6746. https://doi.org/10.1002/adma.201502762
Article CAS Google Scholar
He YJ, Zhang B, Chen YH, Jin QF, Wu JR, Yan F, Zheng HR (2017) Image-guided hydrogen gas delivery for protection from myocardial ischemia–reperfusion injury via microbubbles. ACS Appl Mater Interfaces 9:21190–21199. https://doi.org/10.1021/acsami.7b05346
Article CAS Google Scholar
Huang HY, Hu SH, Hung SY, Chiang CS, Liu HL, Chiu TL, Lai HY, Chen YY, Chen SY (2013) SPIO nanoparticle-stabilized PAA-F127 thermosensitive nanobubbles with MR/US dual-modality imaging and HIFU-triggered drug release for magnetically guided in vivo tumor therapy. J Controll Release 172:118–127. https://doi.org/10.1016/j.jconrel.2013.07.029
Article CAS Google Scholar
Huang HY, Liu HL, Hsu PH, Chiang CS, Tsai CH, Chi HS, Chen SY, Chen YY (2015) A multitheragnostic nanobubble system to induce blood-brain barrier disruption with magnetically guided focused ultrasound. Adv Mater 27:655–661. https://doi.org/10.1002/adma.201403889
Article CAS Google Scholar
Huang CC, Liao ZX, Lu HM, Pan WY, Wan WL, Chen CC, Sung HW (2016a) Cellular organelle-dependent cytotoxicity of iron oxide nanoparticles and its implications for cancer diagnosis and treatment: a mechanistic investigation. Chem Mater 28:9017–9025. https://doi.org/10.1021/acs.chemmater.6b03905
Article CAS Google Scholar
Huang CC, Chia WT, Chung MF, Lin KJ, Hsiao CW, Jin C, Lim WH, Chen CC, Sung HW (2016b) An implantable depot that can generate oxygen in situ for overcoming hypoxia-induced resistance to anticancer drugs in chemotherapy. J Am Chem Soc 138:5222–5225. https://doi.org/10.1021/jacs.6b01784
Article CAS Google Scholar
Huerta S, Chilka S, Bonavida B (2008) Nitric oxide donors: novel cancer therapeutics (review). Int J Oncol 33:909–927. https://doi.org/10.3892/ijo_00000079
Article CAS Google Scholar
Huynh E, Jin CS, Wilson BC, Zheng G (2014) Aggregate enhanced trimodal porphyrin shell microbubbles for ultrasound, photoacoustic, and fluorescence imaging. Bioconj Chem 25:796–801. https://doi.org/10.1021/bc5000725
Article CAS Google Scholar
Inaba H, Fujita K, Ueno T (2015) Design of biomaterials for intracellular delivery of carbon monoxide. Biomater Sci 3:1423–1438. https://doi.org/10.1039/c5bm00210a
Article CAS Google Scholar
Ishibashi T (2013) Molecular hydrogen: new antioxidant and anti-inflammatory therapy for rheumatoid arthritis and related diseases. Curr Pharm Des 19:6375–6381. https://doi.org/10.2174/13816128113199990507
Article CAS Google Scholar
Ji X, Wang B (2018) Strategies toward organic carbon monoxide prodrugs. Acc Chem Res 51:1377–1385. https://doi.org/10.1021/acs.accounts.8b00019
Article CAS Google Scholar
Ji X, Zhou C, Ji K, Aghoghovbia RE, Pan Z, Chittavong V, Ke B, Wang B (2016) Click and release: a chemical strategy toward developing gasotransmitter prodrugs by using an intramolecular Diels–Alder reaction. Angew Chem Int Ed 55:15846–15851. https://doi.org/10.1002/anie.201608732
Article CAS Google Scholar
Ji X, De La Cruz LKC, Pan Z, Chittavong V, Wang B (2017a) Ph-Sensitive metal-free carbon monoxide prodrugs with tunable and predictable release rates. Chem Commun 53:9628–9631. https://doi.org/10.1039/C7CC04866A
Article CAS Google Scholar
Ji XY, El-Labbad EM, Ji KL, Lasheen DS, Serya RAT, Abouzid KA, Wang BH (2017b) Click and release: SO₂ prodrugs with tunable release rates. Org Lett 19:818–821. https://doi.org/10.1021/acs.orglett.6b03805
Article CAS Google Scholar
Ji X, Ji K, Chittavong V, Yu B, Pan Z, Wang B (2017c) An esterase-activated click and release approach to metal-free CO-prodrugs. Chem Commun 53:8296–8299. https://doi.org/10.1039/c7cc03832a
Article CAS Google Scholar
Jin Z, Wen Y, Xiong L, Yang T, Zhao P, Tan L, Wang T, Qian Z, Su B-L, He Q (2017) Intratumoral H₂O₂-triggered release of CO from a metal carbonyl-based nanomedicine for efficient CO therapy. Chem Commun 53:5557–5560. https://doi.org/10.1039/c7cc01576c
Article CAS Google Scholar
Jin Q, Deng Y, Jia F, Tang Z, Ji J (2018) Gas therapy: an emerging “green” strategy for anticancer therapeutics. Adv Ther 1:1800084. https://doi.org/10.1002/adtp.201800084
Article Google Scholar
Jordan BF, Sonveaux P, Feron O, Greǵoire V, Beghein N, Dessy C, Gallez B (2004) Nitric oxide as a radiosensitizer: evidence for an intrinsic role in addition to its effect on oxygen delivery and consumption. Int J Cancer 109:768–773. https://doi.org/10.1002/ijc.20046
Article CAS Google Scholar
Kang E, Min HS, Lee J, Han MH, Ahn HJ, Yoon IC, Choi K, Kim K, Park K, Kwon IC (2010) Nanobubbles from gas-generating polymeric nanoparticles: ultrasound imaging of living subjects. Angew Chem Int Ed 49:524–528. https://doi.org/10.1002/anie.200903841
Article CAS Google Scholar
Kang C, Cho W, Park M, Kim J, Park S, Shin D, Song C, Lee D (2016) H₂O₂-Triggered bubble generating antioxidant polymeric nanoparticles as ischemia/reperfusion targeted nano-theranostics. Biomaterials 85:195–203. https://doi.org/10.1016/j.biomaterials.2016.01.070
Article CAS Google Scholar
Kautz AC, Kunz PC, Janiak C (2016) CO-Releasing molecule (CORM) conjugate systems. Dalton Trans 45:18045–18063. https://doi.org/10.1039/c6dt03515a
Article CAS Google Scholar
Ke CJ, Su TY, Chen HL, Liu HL, Chiang WL, Chu PC, Xia Y, Sung HW (2011) Smart multifunctional hollow microspheres for the quick release of drugs in intracellular lysosomal compartments. Angew Chem Int Ed 50:8086–8089. https://doi.org/10.1002/anie.201102852
Article CAS Google Scholar
Ke CJ, Lin YJ, Hu YC, Chiang WL, Chen KJ, Yang WC, Liu HL, Fu CC, Sung HW (2012) Multidrug release based on microneedle arrays filled with pH-responsive PLGA hollow microspheres. Biomaterials 33:5156–5165. https://doi.org/10.1016/j.biomaterials.2012.03.056
Article CAS Google Scholar
Ke CJ, Chiang WL, Liao ZX, Chen HL, Lai PS, Sun JS, Sung HW (2013) Real-time visualization of pH-responsive PLGA hollow particles containing a gas-generating agent targeted for acidic organelles for overcoming multi-drug resistance. Biomaterials 34:1–10. https://doi.org/10.1016/j.biomaterials.2012.09.023
Article CAS Google Scholar
Ke H, Wang J, Tong S, Jin Y, Wang S, Qu E, Bao G, Dai Z (2014) Gold nanoshelled liquid perfluorocarbon magnetic nano-capsules: a nanotheranostic platform for bimodal ultrasound/magnetic resonance imaging guided photothermal tumor ablation. Theranostics 4:12–23. https://doi.org/10.7150/thno.7275
Article CAS Google Scholar
Kim J, Cho HR, Jeon H, Kim D, Song C, Lee N, Choi SH, Hyeon T (2017a) Continuous O₂-evolving MnFe₂O₄ nanoparticle-anchored mesoporous silica nanoparticles for efficient photo-dynamic therapy in hypoxic cancer. J Am Chem Soc 139:10992–10995. https://doi.org/10.1021/jacs.7b05559
Article CAS Google Scholar
Kim J, Yung BC, Kim WJ, Chen X (2017b) Combination of nitric oxide and drug delivery systems: tools for overcoming drug resistance in chemotherapy. J Controll Release 263:223–230. https://doi.org/10.1016/j.jconrel.2016.12.026
Article CAS Google Scholar
Kunz PC, Meyer H, Barthel J, Sollazzo S, Schmidt AM, Janiak C (2013) Metal carbonyls supported on iron oxide nano-particles to trigger the CO-gasotransmitter release by magnetic heating. Chem Commun 49:4896–4898. https://doi.org/10.1039/c3cc41411f
Article CAS Google Scholar
Lee J, Min H-S, You DG, Kim K, Kwon IC, Rhim T, Lee KY (2016) Theranostic gas-generating nanoparticles for targeted ultrasound imaging and treatment of neuroblastoma. J Controll Release 223:197–206. https://doi.org/10.1016/j.jconrel.2015.12.051
Article CAS Google Scholar
Lee J, Jo SD, Chung H, Um W, Chandrasekar R, Choi YH, Shalaev VM, Won YY (2018) Laser-induced CO₂ generation from gold nanorod-containing poly (propylene carbonate)-based block polymer micelles for ultrasound contrast enhancement. ACS Appl Mater Interfaces 10:26084–26098. https://doi.org/10.1021/acsami.8b09630
Article CAS Google Scholar
Lefer DJ (2007) A new gaseous signaling molecule emerges: cardioprotective role of hydrogen sulfide. Proc Natl Acad Sci USA 104:17907–17908. https://doi.org/10.1073/pnas.0709010104
Article Google Scholar
Li M, Li J, Zhang T, Zhao Q, Cheng J, Liu B, Wang Z, Zhao L, Wang C (2017a) Syntheses, toxicities and anti-inflammation of H2S-donors based on non-steroidal anti-inflammatory drugs. Eur J Med Chem 138:51–65. https://doi.org/10.1016/j.ejmech.2017.06.012
Article CAS Google Scholar
Li SY, Cheng H, Xie BR, Qiu WX, Zeng JY, Li CX, Wan SS, Zhang L, Liu WL, Zhang XZ (2017b) Cancer cell membrane camouflaged cascade bioreactor for cancer targeted starvation and photodynamic therapy. ACS Nano 11:7006–7018. https://doi.org/10.1021/acsnano.7b02533
Article CAS Google Scholar
Li M, Sun X, Zhang N, Wang W, Yang Y, Jia H, Liu W (2018a) NIR-activated polydopamine-coated carrier-free “nanobomb” for in situ on-demand drug release. Adv Sci 5:1800155. https://doi.org/10.1002/advs.201800155
Article CAS Google Scholar
Li Y, Chen Y, Du M, Chen ZY (2018b) Ultrasound technology for molecular imaging: from contrast agents to multimodal imaging. ACS Biomater Sci Eng 4:2716–2728. https://doi.org/10.1021/acsbiomaterials.8b00421
Article CAS Google Scholar
Li S, Liu R, Jiang X, Qiu Y, Song X, Huang G, Fu N, Lin L, Song J, Chen X, Yang H (2019) Near-infrared light triggered sulfur dioxide gas therapy of cancer. ACS Nano 13:2103–2113. https://doi.org/10.1021/acsnano.8b08700
Article CAS Google Scholar
Liao ZX, Chuang EY, Lin CC, Ho YC, Lin KJ, Cheng PY, Chen KJ, Wei HJ, Sung HW (2015) An AS1411 aptamer-conjugated liposomal system containing a bubble-generating agent for tumor-specific chemotherapy that overcomes multidrug resistance. J Controll Release 208:42–51. https://doi.org/10.1016/j.jconrel.2015.01.032
Article CAS Google Scholar
Lin YJ, Huang CC, Wan WL, Chiang CH, Chang Y, Sung HW (2017) Recent advances in CO₂ bubble-generating carrier systems for localized controlled release. Biomaterials 133:154–164. https://doi.org/10.1016/j.biomaterials.2017.04.018
Article CAS Google Scholar
Lin WC, Pan WY, Liu CK, Huang WX, Song HL, Chang KS, Li MJ, Sung HW (2018) In situ self-spray coating system that can uniformly disperse a poorly water-soluble H2S donor on the colorectal surface to treat inflammatory bowel diseases. Biomaterials 182:289–298. https://doi.org/10.1016/j.biomaterials.2018.07.044
Article CAS Google Scholar
Liu Q, Chen X, Jia J, Zhang W, Yang T, Wang L, Ma G (2015) pH-Responsive poly(d, l-lactic-co-glycolic acid) nanoparticles with rapid antigen release behavior promote immune response. ACS Nano 9:4925–4938. https://doi.org/10.1021/nn5066793
Article CAS Google Scholar
Liu LH, Zhang YH, Qiu WX, Zhang L, Gao F, Li B, Xu L, Fan JX, Li ZH, Zhang XZ (2017a) Dual-stage light amplified photodynamic therapy against hypoxic tumor based on an O₂ self-sufficient nanoplatform. Small 13:1701621. https://doi.org/10.1002/smll.201701621
Article CAS Google Scholar
Liu T, Zhang N, Wang Z, Wu M, Chen Y, Ma M, Chen H, Shi J (2017b) Endogenous catalytic generation of O₂ bubbles for in situ ultrasound-guided high intensity focused ultrasound ablation. ACS Nano 11:9093–9102. https://doi.org/10.1021/acsnano.7b03772
Article CAS Google Scholar
Liu Y, Yang F, Yuan CX, Li MX, Wang TT, Chen B, Jin J, Zhao P, Tong JY, Luo SH, Gu N (2017c) Magnetic nanoliposomes as in situ microbubble bombers for multimodality image-guided cancer theranostics. ACS Nano 11:1509–1519. https://doi.org/10.1021/acsnano.6b06815
Article CAS Google Scholar
Liu JT, Du P, Mao H, Zhang L, Ju HX, Lei JP (2018a) Dual-triggered oxygen self-supply black phosphorus nanosystem for enhanced photodynamic therapy. Biomaterials 172:83–91. https://doi.org/10.1016/j.biomaterials.2018.04.051
Article CAS Google Scholar
Liu CH, Dong HF, Wu NQ, Cao Y, Zhang XJ (2018b) Plasmonic resonance energy transfer enhanced photodynamic therapy with Au@SiO₂@Cu₂O/perfluorohexane nanocomposites. ACS Appl Mater Interfaces 10:6991–7002. https://doi.org/10.1021/acsami.8b00112
Article CAS Google Scholar
Liu J, Xu F, Huang J, Xu J, Liu Y, Yao Y, Ao M, Li A, Hao L, Cao Y, Hu Z, Ran H, Wang Z, Li P (2018c) Low-intensity focused ultrasound (LIFU)-activated nanodroplets as a theranostic agent for noninvasive cancer molecular imaging and drug delivery. Biomater Sci 6:2838–2849. https://doi.org/10.1039/c8bm00726h
Article CAS Google Scholar
Loboda A, Jozkowicz A, Dulak J (2015) HO-1/CO system in tumor growth, angiogenesis and metabolism-targeting HO-1 as an anti-tumor therapy. Vasc Pharmacol 74:11–22. https://doi.org/10.1016/j.vph.2015.09.004
Article CAS Google Scholar
Ma M, Xu H, Chen H, Jia X, Zhang K, Wang Q, Zheng S, Wu R, Yao M, Cai X, Li F, Shi J (2014) A drug-perfluorocarbon nanoemulsion with an ultrathin silica coating for the synergistic effect of chemotherapy and ablation by high-intensity focused ultrasound. Adv Mater 26:7378–7385. https://doi.org/10.1002/adma.201402969
Article CAS Google Scholar
Ma R, Wu Q, Si T, Chang S, Xu RX (2017) Oxygen and indocyanine green loaded microparticles for dual-mode imaging and sonodynamic treatment of cancer cells. Ultrason Sonochem 39:197–207. https://doi.org/10.1016/j.ultsonch.2017.03.019
Article CAS Google Scholar
Malwal SR, Chakrapani H (2015) Benzosulfones as photochemically activated sulfur dioxide (SO₂) donors. Org Biomol Chem 13:2399–2406. https://doi.org/10.1039/c4ob02466d
Article CAS Google Scholar
Malwal SR, Sriram D, Yogeeswari P, Konkimalla VB, Chakrapani H (2012) Design, synthesis, and evaluation of thiol-activated sources of sulfur dioxide (SO₂) as antimycobacterial agents. J Med Chem 55:553–557. https://doi.org/10.1021/jm201023g
Article CAS Google Scholar
McEwan C, Owen J, Stride E, Fowley C, Nesbitt H, Cochrane D, Coussios CC, Borden M, Nomikou N, McHale AP, Callan JF (2015) Oxygen carrying microbubbles for enhanced sonodynamic therapy of hypoxic tumours. J Controll Release 203:51–56. https://doi.org/10.1016/j.jconrel.2015.02.004
Article CAS Google Scholar
Meyer H, Winkler F, Kunz P, Schmidt AM, Hamacher A, Kassack MU, Janiak C (2015) Stabilizing alginate confinement and polymer coating of CO-releasing molecules supported on iron oxide nanoparticles to trigger the CO release by magnetic heating. Inorg Chem 54:11236–11246. https://doi.org/10.1021/acs.inorgchem.5b01675
Article CAS Google Scholar
Meyer H, Brenner M, Höfert SP, Knedel TO, Kunz PC, Schmidt AM, Hamacher A, Kassack MU, Janiak C (2016) Synthesis of oxime-based CO-releasing molecules, corms and their immobilization on maghemite nanoparticles for magnetic-field induced CO release. Dalton Trans 45:7605–7615. https://doi.org/10.1039/c5dt04888e
Article CAS Google Scholar
Min KH, Min HS, Lee HJ, Park DJ, Yhee JY, Kim K, Kwon IC, Jeong SY, Silvestre OF, Chen X et al (2015) Ph-Controlled gas-generating mineralized nanoparticles: a theranostic agent for ultrasound imaging and therapy of cancers. ACS Nano 9:134–145. https://doi.org/10.1021/nn506210a
Article CAS Google Scholar
Min HS, Son S, You DG, Lee TW, Lee J, Lee S, Yhee JY, Lee J, Han MH, Park JH et al (2016) Chemical gas-generating nanoparticles for tumor-targeted ultrasound imaging and ultrasound-triggered drug delivery. Biomaterials 108:57–70. https://doi.org/10.1016/j.biomaterials.2016.08.049
Article CAS Google Scholar
Motterlini R, Otterbein LE (2010) The therapeutic potential of carbon monoxide. Nat Rev Drug Discov 9:728–743. https://doi.org/10.1038/nrd3228
Article CAS Google Scholar
Nayor M, Enserro DM, Beiser AS, Cheng S, Decarli C, Vasan RS, Seshadri S (2016) Association of exhaled carbon monoxide with stroke incidence and subclinical vascular brain injury: the Framingham study. Stroke 47:383–389. https://doi.org/10.1161/strokeaha.115.010405
Article CAS Google Scholar
Niu N, Zhang Z, Gao X, Chen ZJ, Li SJ, Li J (2018) Photodynamic therapy in hypoxia: near-infrared-sensitive, self-supported, oxygen generation nano-platform enabled by up converting nanoparticles. Chem Eng J 352:818–827. https://doi.org/10.1016/j.cej.2018.07.049
Article CAS Google Scholar
Oh SH, Ward CL, Atala A, Yoo JJ, Harrison BS (2009) Oxygen generating scaffolds for enhancing engineered tissue survival. Biomaterials 30:757–762. https://doi.org/10.1016/j.biomaterials.2008.09.065
Article CAS Google Scholar
Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura KI, Katayama Y, Asoh S, Ohta S (2007) Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 13:688. https://doi.org/10.1038/nm1577
Article CAS Google Scholar
Otterbein LE, Bach FH, Alam J, Soares M, Tao LH, Wysk M, Davis RJ, Flavell RA, Choi AM (2000) Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med 6:422–428. https://doi.org/10.1038/74680
Article CAS Google Scholar
Palao E, Slanina T, Muchova L, Šolomek T, Vítek L, Klań P (2016) Transition-metal-FreeCO-releasing BODIPY derivatives activatable by visible to NIR light as promising bioactive molecules. J Am Chem Soc 138:126–133. https://doi.org/10.1021/jacs.5b10800
Article CAS Google Scholar
Paproski RJ, Forbrich A, Huynh E, Chen J, Lewis JD, Zheng G, Zemp RJ (2016) Porphyrin nanodroplets: sub-micrometer ultrasound and photoacoustic contrast imaging agents. Small 12:371–380. https://doi.org/10.1002/smll.201502450
Article CAS Google Scholar
Pardeshi KA, Malwal SR, Banerjee A, Lahiri S, Rangarajan R, Chakrapani H (2015) Thiol activated prodrugs of sulfur dioxide (SO₂) as MRSA inhibitors. Bioorg Med Chem Lett 25:2694–2697. https://doi.org/10.1016/j.bmcl.2015.04.046
Article CAS Google Scholar
Pedraza E, Coronel MM, Fraker CA, Ricordi C, Stabler CL (2012) Preventing hypoxia-induced cell death in beta cells and islets via hydrolytically activated, oxygen-generating biomaterials. Proc Natl Acad Sci USA 109:4245–4250. https://doi.org/10.1073/pnas.1113560109
Article Google Scholar
Pierri AE, Huang P-J, Garcia JV, Stanfill JG, Chui M, Wu G, Zheng N, Ford PC (2015) A photocorm nanocarrier for CO release using NIR light. Chem Commun 51:2072–2075. https://doi.org/10.1039/C4CC06766E
Article CAS Google Scholar
Powell CR, Foster JC, Okyere B, Theus MH, Matson JB (2016) Therapeutic delivery of H₂S via COS: small molecule and polymeric donors with benign byproducts. J Am Chem Soc 138:13477–13480. https://doi.org/10.1021/jacs.6b07204
Article CAS Google Scholar
Powell CR, Dillon KM, Matson JB (2018) A review of hydrogen sulfide (H₂S) donors: chemistry and potential therapeutic applications. Biochem Pharmacol 149:110–123. https://doi.org/10.1016/j.bcp.2017.11.014
Article CAS Google Scholar
Quinn JF, Whittaker MR, Davis TP (2015) Delivering nitric oxide with nanoparticles. J Controll Release 205:190–205. https://doi.org/10.1016/j.jconrel.2015.02.007
Article CAS Google Scholar
Romanski S, Kraus B, Schatzschneider U, Neudörfl JM, Amslinger S, Schmalz HG (2011) Acyloxybutadiene iron tricarbonyl complexes as enzyme-triggered CO-releasing molecules (ET-CORMs). Angew Chem Int Ed 50:2392–2396. https://doi.org/10.1002/anie.201006598
Article CAS Google Scholar
Romanski S, Rücker H, Stamellou E, Guttentag M, Neudörfl J, Alberto R, Amslinger S, Yard B, Schmalz H (2012) Iron dienylphosphate tricarbonyl complexes as water-soluble enzyme-triggered CO-releasing molecules (ET-CORMs). Organometallics 31:5800–5809. https://doi.org/10.1021/om300359a
Article CAS Google Scholar
Romao CC, Blaẗtler WA, Seixas JD, Bernardes GJ (2012) Developing drug molecules for therapy with carbon monoxide. Chem Soc Rev 41:3571–3583. https://doi.org/10.1039/c2cs15317c
Article CAS Google Scholar
Santiesteban DY, Dumani DS, Profili D, Emelianov SY (2017) Copper sulfide perfluorocarbon nanodroplets as clinically relevant photoacoustic/ultrasound imaging agents. Nano Lett 17:5984. https://doi.org/10.1021/acs.nanolett.7b02105
Article CAS Google Scholar
Seabra AB, de Lima R, Calderon M (2015) Nitric oxide releasing nanomaterials for cancer treatment: current status and perspectives. Curr Top Med Chem 15:298–308. https://doi.org/10.2174/1568026615666150108122918
Article CAS Google Scholar
Sharma AK, Nair M, Chauhan P, Gupta K, Saini DK, Chakrapani H (2017) Visible-light-triggered uncaging of carbonyl sulfide for hydrogen sulfide (H₂S) release. Org Lett 19:4822–4825. https://doi.org/10.1021/acs.orglett.7b02259
Article CAS Google Scholar
Shen W, Liu WG, Yang HL, Zhang P, Xiao CS, Chen XS (2018) A glutathione-responsive sulfur dioxide polymer prodrug as a nanocarrier for combating drug-resistance in cancer chemotherapy. Biomaterials 178:706–719. https://doi.org/10.1016/j.biomaterials.2018.02.011
Article CAS Google Scholar
Sitnikov NS, Li Y, Zhang D, Yard B, Schmalz HG (2015) Design, synthesis, and functional evaluation of CO-releasing molecules triggered by penicillin G amidase as a model protease. Angew Chem Int Ed 54:12314–12318. https://doi.org/10.1002/anie.201502445
Article CAS Google Scholar
Snipstad S, Sulheim E, de Lange Davies C, Moonen C, Storm G, Kiessling F, Schmid R, Lammers T (2018) Sonopermeation to improve drug delivery to tumors: from fundamental understanding to clinical translation. Expert Opin Drug Deliv 15:1249–1261. https://doi.org/10.1080/17425247.2018.1547279
Article CAS Google Scholar
Soboleva T, Esquer HJ, Benninghoff AD, Berreau LM (2017) Sense and release: a thiol-responsive flavonol-based photonically driven carbon monoxide-releasing molecule that operates via a multiple-input and logic gate. J Am Chem Soc 139:9435–9438. https://doi.org/10.1021/jacs.7b04077
Article CAS Google Scholar
Son S, Min HS, You DG, Kim BS, Kwon IC (2014) Echogenic nanoparticles for ultrasound technologies: evolution from diagnostic imaging modality to multimodal theranostic agent. Nano Today 9:525–540. https://doi.org/10.1016/j.nantod.2014.06.002
Article CAS Google Scholar
Song M, Liu T, Shi C, Zhang X, Chen X (2016) Bioconjugated manganese dioxide nanoparticles enhance chemotherapy response by priming tumor-associated macrophages toward M1-like phenotype and attenuating tumor hypoxia. ACS Nano 10:633–647. https://doi.org/10.1021/acsnano.5b06779
Article CAS Google Scholar
Song G, Ji C, Liang C, Song X, Yi X, Dong Z, Yang K, Liu Z (2017) TaOx decorated perfluorocarbon nanodroplets as oxygen reservoirs to overcome tumor hypoxia and enhance cancer radiotherapy. Biomaterials 112:257–263. https://doi.org/10.1016/j.biomaterials.2016.10.020
Article CAS Google Scholar
Song R, Hu D, Chung HY, Sheng Z, Yao S (2018) Lipid-polymer bilaminar oxygen nanobubbles for enhanced photodynamic therapy of cancer. ACS Appl Mater Interfaces 10:36805–36813. https://doi.org/10.1021/acsami.8b15293
Article CAS Google Scholar
Steiger C, Lühmann T, Meinel L (2014) Oral drug delivery of therapeutic gases-carbon monoxide release for gastrointestinal diseases. J Controll Release 189:46–53. https://doi.org/10.1016/j.jconrel.2014.06.025
Article CAS Google Scholar
Steiger AK, Marcatti M, Szabo C, Szczesny B, Pluth MD (2017) Inhibition of mitochondrial bioenergetics by esterase-triggered COS/H₂S donors. ACS Chem Biol 12:2117–2123. https://doi.org/10.1021/acschembio.7b00279
Article CAS Google Scholar
Sun X, Kong B, Wang W, Chandran P, Selomulya C, Zhang H, Zhu K, Liu Y, Yang W, Guo C et al (2015) Mesoporous silica nanoparticles for glutathione-triggered long-range and stable release of hydrogen sulfide. J Mater Chem B 3:4451–4457. https://doi.org/10.1039/c5tb00354g
Article CAS Google Scholar
Sun X, Wang W, Dai J, Jin S, Huang J, Guo C, Wang C, Pang L, Wang Y (2017) A long-term and slow-releasing hydrogen sulfide donor protects against myocardial ischemia/reperfusion injury. Sci Rep 7:3541. https://doi.org/10.1038/s41598-017-03941-0
Article CAS Google Scholar
Szabo C (2007) Hydrogen sulphide and its therapeutic potential. Nat Rev Drug Discov 6:917. https://doi.org/10.1038/nrd2425
Article CAS Google Scholar
Szabo C (2016) Gasotransmitters in cancer: from pathophysiology to experimental therapy. Nat Rev Drug Discov 15:185. https://doi.org/10.1038/nrd.2015.1
Article CAS Google Scholar
Tan MJ, Pan HC, Tan HR, Chai JW, Lim QF, Wong TI, Zhou X, Hong ZY, Liao LD, Kong KV (2018) Hybrid materials: flexible modulation of CO-release using various nuclearity of metal carbonyl clusters on graphene oxide for stroke remediation. Adv Healthc Mater 7:1870022. https://doi.org/10.1002/adhm.201870022
Article CAS Google Scholar
Teng Z, Wang R, Zhou Y, Kolios M, Wang Y, Zhang N, Wang Z, Zheng Y, Lu G (2017) A magnetic droplet vaporization approach using perfluorohexane-encapsulated magnetic mesoporous particles for ultrasound imaging and tumor ablation. Biomaterials 134:43–50. https://doi.org/10.1016/j.biomaterials.2017.04.021
Article CAS Google Scholar
Upendar Reddy G, Axthelm J, Hoffmann P, Taye N, Glaeser S, Görls H, Hopkins SL, Plass W, Neugebauer U, Bonnet S et al (2017) Co-registered molecular logic gate with a CO-releasing molecule triggered by light and peroxide. J Am Chem Soc 139:4991–4994. https://doi.org/10.1021/jacs.7b00867
Article CAS Google Scholar
Wan WL, Lin YJ, Chen HL, Huang CC, Shih PC, Bow YR, Chia WT, Sung HW (2017) In situ nanoreactor for photosynthesizing H₂ gas to mitigate oxidative stress in tissue inflammation. J Am Chem Soc 139:12923–12926. https://doi.org/10.1021/jacs.7b07492
Article CAS Google Scholar
Wan SS, Zeng JY, Cheng H, Zhang XZ (2018) ROS-induced NO generation for gas therapy and sensitizing photodynamic therapy of tumor. Biomaterials 185:51–62. https://doi.org/10.1016/j.biomaterials.2018.09.004
Article CAS Google Scholar
Wang XB, Jin HF, Tang CS, Du JB (2011) The biological effect of endogenous sulfur dioxide in the cardiovascular system. Eur J Pharmacol 670:1–6. https://doi.org/10.1016/j.ejphar.2011.08.031
Article CAS Google Scholar
Wang D, Viennois E, Ji K, Damera K, Draganov A, Zheng Y, Dai C, Merlin D, Wang B (2014) A click-and-release approach to CO prodrugs. Chem Commun 50:15890–15893. https://doi.org/10.1039/c4cc07748b
Article CAS Google Scholar
Wang X, Niu D, Li P, Wu Q, Bo X, Liu B, Bao S, Su T, Xu H, Wang Q (2015) Dual-enzyme-loaded multifunctional hybrid nanogel system for pathological responsive ultrasound imaging and T₂-weighted magnetic resonance imaging. ACS Nano 9:5646–5656. https://doi.org/10.1021/nn5068094
Article CAS Google Scholar
Wang WY, Ji XY, Du ZM, Wang BH (2017) Sulfur dioxide prodrugs: triggered release of SO₂ via a click reaction. Chem Commun 53:1370–1373. https://doi.org/10.1039/c6cc08844a
Article CAS Google Scholar
Wang Q, Li JM, Yu H, Deng K, Zhou W, Wang CX, Zhang Y, Li KH, Zhuo RX, Huang SW (2018) Fluorinated polymeric micelles to overcome hypoxia and enhance photo-dynamic cancer therapy. Biomater Sci 6:3096–3107. https://doi.org/10.1039/c8bm00852c
Article CAS Google Scholar
Wegiel B, Gallo D, Csizmadia E, Harris C, Belcher J, Vercellotti GM, Penacho N, Seth P, Sukhatme V, Ahmed A, Pandolfi PP, Helczynski L, Bjartell A, Persson JL, Otterbein LE (2013) Carbon monoxide expedites metabolic exhaustion to inhibit tumor growth. Cancer Res 73:7009–7021. https://doi.org/10.1158/0008-5472.CAN-13-1075
Article CAS Google Scholar
Wilson K, Homan K, Emelianov S (2012) Biomedical photo-acoustics beyond thermal expansion using triggered nanodroplet vaporization for contrast-enhanced imaging. Nat Commun 3:618. https://doi.org/10.1038/ncomms1627
Article CAS Google Scholar
Wollborn J, Hermann C, Goebel U, Merget B, Wunder C, Maier S, Schaefer T, Heuler D, Mueller-Buschbaum K, Buerkle H, Meinel L, Schick MA, Steiger C (2018) Overcoming safety challenges in CO therapy: extracorporeal CO delivery under precise feedback control of systemic carboxyhemoglobin levels. J Controll Release 279:336–344. https://doi.org/10.1016/j.jconrel.2018.04.017
Article CAS Google Scholar
Woods JJ, Cao J, Lippert AR, Wilson JJ (2018) Characterization and biological activity of a hydrogen sulfide-releasing red light-activated Ruthenium(II) complex. J Am Chem Soc 140:12383–12387. https://doi.org/10.1021/jacs.8b08695
Article CAS Google Scholar
Xiang HJ, Deng Q, An L, Guo M, Yang SP, Liu JG (2016) Tumor cell specific and lysosome-targeted delivery of nitric oxide for enhanced photodynamic therapy triggered by 808 nm near-infrared light. Chem Commun 52:148–151. https://doi.org/10.1039/c5cc07006f
Article CAS Google Scholar
Xiao Z, Bonnard T, Shakouri-Motlagh A, Wylie RAL, Collins J, White J, Heath DE, Hagemeyer CE, Connal LA (2017) Triggered and tunable hydrogen sulfide release from photo-generated thiobenzaldehydes. Chem Eur J 23:11294–11300. https://doi.org/10.1002/chem.201701206
Article CAS Google Scholar
Yamamoto T, Takano N, Ishiwata K, Ohmura M, Nagahata Y, Matsuura T, Kamata A, Sakamoto K, Nakanishi T, Kubo A, Hishiki T, Suematsu M (2014) Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway. Nat Commun 5:3480. https://doi.org/10.1038/ncomms4480
Article CAS Google Scholar
Yang F, Hu S, Zhang Y, Cai X, Huang Y, Wang F, Wen S, Teng G, Gu N (2012) A hydrogen peroxide-responsive O₂ nanogenerator for ultrasound and magnetic-resonance dual modality imaging. Adv Mater 24:5205–5211. https://doi.org/10.1002/adma.201202367
Article CAS Google Scholar
Yang L, Wen Z, Long Y, Huang N, Cheng Y, Zhao L, Zheng H (2016) AH+-triggered bubble-generating nanosystem for killing cancer cells. Chem Commun 52:10838–10841. https://doi.org/10.1039/c6cc04511a
Article CAS Google Scholar
Yang G, Xu L, Chao Y, Xu J, Sun X, Wu Y, Peng R, Liu Z (2017) Hollow MnO₂ as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses. Nat Commun 8:902. https://doi.org/10.1038/s41467-017-01050-0
Article CAS Google Scholar
Yang Q, Chen HL, Bai Y, Cao Y, Hu WJ, Zhang LK (2018a) Facile synthesis of lipid-perfluorocarbon nanoemulsion coated with silica shell as an ultrasound imaging agent. Adv Healthc Mater 7:1700816. https://doi.org/10.1002/adhm.201700816
Article CAS Google Scholar
Yang T, Jin ZK, Wang ZH, Zhao PH, Zhao B, Fan MJ, Chen LH, Wang TF, Su BL, He QJ (2018b) Intratumoral high-payload delivery and acid-responsive release of H2 for efficient cancer therapy using the ammonia borane-loaded mesoporous silica nanomedicine. Appl Mater Today 11:136–143. https://doi.org/10.1016/j.apmt.2018.01.008
Article Google Scholar
Yi SY, Moon YK, Kim S, Kim S, Park G, Kim JJ, You Y (2017) Visible light-driven photogeneration of hydrogen sulfide. Chem Commun 53:11830–11833. https://doi.org/10.1039/C7CC06990A
Article CAS Google Scholar
Yildirim A, Chattaraj R, Blum NT, Goldscheitter GM, Goodwin AP (2016) Stable encapsulation of air in mesoporous silica nanoparticles: fluorocarbon-free nanoscale ultrasound contrast agents. Adv Healthc Mater 5:1290–1298. https://doi.org/10.1002/adhm.201600030
Article CAS Google Scholar
Yin H, Fang J, Liao L, Nakamura H, Maeda H (2014) Styrene-maleic acid copolymer-encapsulated CORM2, a water-soluble carbon monoxide (CO) donor with a constant CO-releasing property, exhibits therapeutic potential for inflammatory bowel disease. J Control Rel 187:14–21. https://doi.org/10.1016/j.jconrel.2014.05.018
Article CAS Google Scholar
Yu L, Hu P, Chen Y (2018a) Gas-generating nanoplatforms: material chemistry, multifunctionality, and gas therapy. Adv Mater. https://doi.org/10.1002/adma.201801964
Article Google Scholar
Yu M, Xu XL, Cai YJ, Zou LY, Shuai XT (2018b) Perfluorohexane-cored nanodroplets for stimulations-responsive ultrasonography and O₂-potentiated photodynamic therapy. Biomaterials 175:61–71. https://doi.org/10.1016/j.biomaterials.2018.05.019
Article CAS Google Scholar
Zhang L, Wang Y, Cao Y, Lou D, Wang B (2013a) Transport barriers and strategies of antitumor nanocarriers delivery system. J Biomed Mater Res A 101:3661–3669. https://doi.org/10.1002/jbm.a.34635
Article CAS Google Scholar
Zhang M, Shan H, Wang T, Liu W, Wang Y, Wang L, Zhang L, Chang P, Dong W, Chen X et al (2013b) Dynamic change of hydrogen sulfide after traumatic brain injury and its effect in mice. Neurochem Res 38:714–725. https://doi.org/10.1007/s11064-013-0969-4
Article CAS Google Scholar
Zhang K, Xu H, Chen H, Jia X, Zheng S, Cai X, Wang R, Mou J, Zheng Y, Shi J (2015) CO₂ bubbling-based ‘nanobomb’ system for targetedly suppressing Panc-1 pancreatic tumor via low intensity ultrasound-activated inertial cavitation. Theranostics 5:1291–1302. https://doi.org/10.7150/thno.12691
Article CAS Google Scholar
Zhang N, Cai X, Gao W, Wang R, Xu C, Yao Y, Hao L, Sheng D, Chen H, Wang Z et al (2016) A multifunctional theranostic nanoagent for dual-mode image-guided HIFU/chemo-synergistic cancer therapy. Theranostics 6:404–417. https://doi.org/10.7150/thno.13478
Article CAS Google Scholar
Zhang C, Chen WH, Liu LH, Qiu WX, Yu WY, Zhang XZ (2017) An O₂ self-supplementing and reactive-oxygen-species-circulating amplified nanoplatform via H₂O/H₂O₂ splitting for tumor imaging and photodynamic therapy. Adv Funct Mater 27:1700626. https://doi.org/10.1002/adfm.201700626
Article CAS Google Scholar
Zhao Y, Pluth MD (2016) Hydrogen sulfide donors activated by reactive oxygen species. Angew. Chem. Int. Ed. 55:14638–14642. https://doi.org/10.1002/anie.201608052
Article CAS Google Scholar
Zhao Y, Wang H, Xian M (2011) Cysteine-Activated Hydrogen Sulfide (H₂S) donors. J Am Chem Soc 133:15–17. https://doi.org/10.1021/ja1085723
Article CAS Google Scholar
Zhao Y, Song W, Wang D, Ran H, Wang R, Yao Y, Wang Z, Zheng Y, Li P (2015) Phase-shifted PFH@PLGA/Fe₃O₄ nanocapsules for MRI/US imaging and photothermal therapy with near-infrared irradiation. ACS Appl Mater Interfaces 7:14231–14242. https://doi.org/10.1021/acsami.5b01873
Article CAS Google Scholar
Zhao Y, Bolton SG, Pluth MD (2017a) Light-activated COS/H₂S donation from photocaged thiocarbamates. Org Lett 19:2278–2281. https://doi.org/10.1021/acs.orglett.7b00808
Article CAS Google Scholar
Zhao Y, Henthorn HA, Pluth MD (2017b) Kinetic insights into hydrogen sulfide delivery from caged-carbonyl sulfide isomeric donor platforms. J Am Chem Soc 139:16365–16376. https://doi.org/10.1021/jacs.7b09527
Article CAS Google Scholar
Zhao P, Jin Z, Chen Q, Yang T, Chen D, Meng J, Lu X, Gu Z, He Q (2018a) Local generation of hydrogen for enhanced photothermal therapy. Nat Commun 9:4241. https://doi.org/10.1038/s41467-018-06630-2
Article CAS Google Scholar
Zhao Y, Steiger AK, Pluth MD (2018b) Cysteine-activated hydrogen sulfide (H₂S) delivery through caged carbonyl sulfide (COS) donor motifs. Chem Commun 54:4951–4954. https://doi.org/10.1039/C8CC02428F
Article CAS Google Scholar
Zheng WL, Zhou J, Chen CS, Zhao Y, Tan CH, Li L, Moore PK, Deng LW (2011) The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo. PLoS ONE. https://doi.org/10.1371/journal.pone.0021077
Article Google Scholar
Zheng DW, Li B, Li CX, Fan JX, Lei Q, Li C, Xu Z, Zhang XZ (2016) Carbon-dot-decorated carbon nitride nanoparticles for enhanced photodynamic therapy against hypoxic tumor via water splitting. ACS Nano 10:8715–8722. https://doi.org/10.1021/acsnano.6b04156
Article CAS Google Scholar
Zheng DW, Li B, Li CX, Xu L, Fan JX, Lei Q, Zhang XZ (2017) Photocatalyzing CO₂ to CO for enhanced cancer therapy. Adv Mater 29:1703822. https://doi.org/10.1002/adma.201703822
Article CAS Google Scholar
Zhou Y, Wang R, Teng Z, Wang Z, Hu B, Kolios M, Chen H, Zhang N, Wang Y, Li P et al (2016) Magnetic nanoparticle-promoted droplet vaporization for in vivo stimuli-responsive cancer theranostics. NPG Asia Mater. https://doi.org/10.1038/am.2016.146
Article Google Scholar
Zhou ZG, Zhang BL, Wang HR, Yuan A, Hu YQ, Wu JH (2018) Two-stage oxygen delivery for enhanced radiotherapy by perfluorocarbon nanoparticles. Theranostics 8:4898–4911. https://doi.org/10.7150/thno.27598
Article CAS Google Scholar
Zhu M, Du J, Liu AD, Holmberg L, Tang C, Jin H (2014) Effect of endogenous sulfur dioxide in regulating cardiovascular oxidative stress. Histol Histopathol 29:1107–1111. https://doi.org/10.14670/HH-29.1107
Article CAS Google Scholar
Zhu HR, Qin D, Wu YS, Jing BW, Liu JJ, Hazlewood D, Zhang HM, Feng Y, Yang XM, Wan MX, Wu DC (2018) Laser-activated bioprobes with high photothermal conversion efficiency for sensitive photoacoustic/ultrasound imaging and photothermal sensing. ACS Appl Mater Interfaces 10:29251–29259. https://doi.org/10.1021/acsami.8b08190
Article CAS Google Scholar

Download references

Author information

Authors and Affiliations

State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Xiang, Gulou District, Nanjing, 210009, People’s Republic of China
Hang Zhang, Honghong Chen & Rohit Bavi
Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, 211198, Jiangsu, People’s Republic of China
Mengying Xie
Axiom Market Research and Consulting™, Pune, 411007, India
Sneha Bavi
School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Yantai University, Yantai, Shandong, People’s Republic of China
Muhammad Sohail
School of Chemical Sciences, Punyashlok Ahilyadevi Holkar Solapur University, Solapur, Maharashtra, India
Rohit Bavi

Authors

Hang Zhang
View author publications
You can also search for this author in PubMed Google Scholar
Mengying Xie
View author publications
You can also search for this author in PubMed Google Scholar
Honghong Chen
View author publications
You can also search for this author in PubMed Google Scholar
Sneha Bavi
View author publications
You can also search for this author in PubMed Google Scholar
Muhammad Sohail
View author publications
You can also search for this author in PubMed Google Scholar
Rohit Bavi
View author publications
You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rohit Bavi.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zhang, H., Xie, M., Chen, H. et al. Gas-mediated cancer therapy. Environ Chem Lett 19, 149–166 (2021). https://doi.org/10.1007/s10311-020-01062-1

Download citation

Received: 14 July 2020
Accepted: 28 July 2020
Published: 07 August 2020
Issue Date: February 2021
DOI: https://doi.org/10.1007/s10311-020-01062-1

Keywords

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions