Issue 9, 2020
From the journal:

Food & Function

Protective effects of alfalfa saponins on oxidative stress-induced apoptotic cells

Yalei Cui,†ab   Boshuai Liu,†a   Xiao Sun,a   Zidan Li,a   Yanyan Chen,a   Zhiguo Guo,a   Hua Liu,a   Defeng Li,ab   Chengzhang Wang,ab   Xiaoyan Zhuab  and  Yinghua Shi ORCID logo *ab  

* Corresponding authors

a College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China
E-mail: annysyh@henau.edu.cn
Fax: +8613803855266

b Henan Key Laboratory of Innovation and Utilization of Grassland Resources, Zhengzhou, Henan, China

Abstract

As is known, alfalfa saponins can be used as a feed additive in a pig's diet and the addition of alfalfa saponins to a pig's diet could improve its antioxidant capacity. However, the mechanism by which alfalfa saponins exert their antioxidant effects has not been studied. To address this issue, H2O2-induced rat intestinal epithelial cells were used to establish an oxidative stress model to explore the protective mechanism of alfalfa saponins in this study. The results demonstrated that alfalfa saponins could rescue the cell proliferation activity, elevate the amount of antioxidant enzymes and downregulate the release of MDA and LDH in H2O2-induced cells. The antioxidant activity of alfalfa saponins was achieved by restoring GSH homeostasis. Further results demonstrated that alfalfa saponins could inhibit cell apoptosis through activating the MAPK signaling pathway. These results elucidated the mechanism by which alfalfa saponins exert their antioxidant effects and provided a potential strategy for alleviating oxidative stress in monogastric animals.

Graphical abstract: Protective effects of alfalfa saponins on oxidative stress-induced apoptotic cells

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Article information

DOI
https://doi.org/10.1039/D0FO01797C
Article type
Paper
Submitted
10 Jul 2020
Accepted
05 Aug 2020
First published
06 Aug 2020
This article is Open Access
Creative Commons BY-NC license

Food Funct., 2020,11, 8133-8140

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Protective effects of alfalfa saponins on oxidative stress-induced apoptotic cells

Y. Cui, B. Liu, X. Sun, Z. Li, Y. Chen, Z. Guo, H. Liu, D. Li, C. Wang, X. Zhu and Y. Shi, Food Funct., 2020, 11, 8133 DOI: 10.1039/D0FO01797C

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