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Biocompatibility evaluation of heparin-conjugated poly(ε-caprolactone) scaffolds in a rat subcutaneous implantation model

  • Biocompatibility Studies
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Abstract

Vascular grafts prepared from synthetic polymers have serious shortcomings that can be resolved by surface modification, such as by immobilizing heparin. In this study, the mechanical properties, biocompatibility, anticoagulation property, and water contact angle of two heparin-conjugated poly(ε-caprolactone) scaffolds (PCL-hexamethylendiamine-heparin, PCL-HMD-H. PCL-lysine-heparin, PCL-LYS-H) were compared to identify a preferred heparin conjugation method. An evaluation of the subcutaneous tissue biocompatibility of the scaffolds demonstrated that PCL-HMD-H had better endothelial cell proliferation than the PCL-LYS-H and was therefore a promising scaffold candidate for use in vascular tissue-engineering.

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Acknowledgements

This study was supported by these grants: National Key R&D Program of China (2017YFC1104100), Beijing Clinical Translational Research of Decelluarized Artificial Blood Vessels from the Capital Health Research and Development of Special (2016-1-2012).

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Authors and Affiliations

  1. Department of Vascular Surgery, Xuan Wu Hospital and Institute of Vascular Surgery, Capital Medical University, 100053, Beijing, China

    Zeqin Xu, Lianrui Guo, Zhu Tong, Cong Wang & Yongquan Gu

  2. School of Materials Science & Engineering, Beijing Institute of Technology, 100081, Beijing, China

    Zengguo Feng, Lin Ye, Xue Geng, Xin Jin & Xin Hui

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  1. Zeqin Xu
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  2. Zengguo Feng
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Correspondence to Yongquan Gu.

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Xu, Z., Feng, Z., Guo, L. et al. Biocompatibility evaluation of heparin-conjugated poly(ε-caprolactone) scaffolds in a rat subcutaneous implantation model. J Mater Sci: Mater Med 31, 76 (2020). https://doi.org/10.1007/s10856-020-06419-0

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