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Expression of Bcl-2 in Imprint Smears of Endometrial Carcinoma

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Abstract

The aims of this study were to determine the expression of Bcl-2 in endometrial adenocarcinomas in imprint smears as an alternative technique rather than the frozen section and to correlate the results with clinicopathologic parameters of primary untreated endometrial cancer patients. One hundred twenty-six patients with endometrial carcinoma were evaluated with samples freshly resected after a total abdominal hysterectomy during a 29-month period. One hundred two cases were type I and 24 type II endometrial adenocarcinomas. Positive expression of Bcl-2 was observed only in type I and in low grade carcinomas. Immunocytochemical findings from Bcl-2 stain, appeared to be a valuable predictor of endometrial cancer diagnosis and postoperative prognosis in most cases in endometrial cytology with imprint smears. Furthermore, positive expression of Bcl-2 was related to morphologic features of less aggressiveness (pathogenetic type I, low-grade, early advanced stage, deep myometrial involvement <1/2 or not) tumors.

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Authors and Affiliations

  1. Department of Cytopathology, General Chest Diseases Hospital of Athens “SOTIRIA”, Athens, Greece

    Kosmas Konstantinos

  2. Pathology Department, “Agia Sofia” Children’s Hospital of Athens, Athens, Greece

    Mitropoulou Georgia

  3. Department of Obstetrics and Gynaecology, Chesterfield Royal Hospital, Derbyshire, UK

    Stamoulas Marios

  4. Department of Cytology, Diagnostic and Therapeutic Center of Athens “Hygeia”, Athens, Greece

    Klapsinou Eirini

  5. Department of Cytopathology, Athens University, Medical School, “Attikon” University Hospital, Athens, Greece

    Marouga Anna

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  1. Kosmas Konstantinos
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  2. Mitropoulou Georgia
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  3. Stamoulas Marios
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  4. Klapsinou Eirini
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Correspondence to Kosmas Konstantinos.

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Conflict of interest. The authors declare that they have no conflict of interest.

Statement of compliance with standards of research involving humans as subjects. The research was approved by the Ethical Review Committee of National and Kapodistrian University of Athens, Health Sciences. Formal and written consents were taken from all patients who agreed to participate in this study.

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Kosmas Konstantinos, Georgia, M., Marios, S. et al. Expression of Bcl-2 in Imprint Smears of Endometrial Carcinoma. Cytol. Genet. 54, 372–378 (2020). https://doi.org/10.3103/S0095452720040064

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