Skip to main content
Log in

Antioxidant and antibacterial effects of medicinal plants and their stick-type medicinal concentrated beverages

  • Published:
Food Science and Biotechnology Aims and scope Submit manuscript

Abstract

Nine medicinal plants and their stick-type medicinal concentrated beverages (SMCB-I and SMCB-II) with different combination ratio were evaluated on antioxidant, nitric oxide (NO) inhibitory, and antibacterial effects against pathogenic bacteria involved in respiratory system illnesses. Antioxidant activity was high in Syzygium aromaticum, Pueraria lobata, Plantago asiatica, and Kalopanax pictus which have higher contents of total phenolics and total flavonoids. The NO inhibitory activity was high in Syzygium aromaticum, Plantago asiatica, and Glycyrrhiza uralensis. Syzygium aromaticum, Plantago asiatica, Kalopanax pictus and Glycyrrhiza uralensis showed higher antibacterial activity than the other five medicinal plants against Staphylococcus aureus, Corynebacterium diphtheriae, and Mycobacterium sp. SMCB-II exhibited higher antioxidant, NO inhibitory, and antibacterial effects than SMCB-I, since Syzygium aromaticum, Pueraria lobata, and Kalopanax pictus were only used for the production of SMCB-II. The SMCBs would be expected to contribute to an easy-to-carry, easy-to-consume, and high value-added health beverage for the modern people.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  • Amakura Y, Yoshimura A, Yoshimura M, Yoshida T. Isolation and characterization of phenolic antioxidants from plantago Herb. Molecules 17: 5459-5466 (2012)

    Article  CAS  Google Scholar 

  • Arao T, Kinjo J, Nohara T, Isobe R. Oleanene-type triterpene glycosidesfrom puerariae radix. IV. Six new saponins from Pueraria lobate. Chem. Pharm. Bull. 45: 362-366 (1997)

    Article  CAS  Google Scholar 

  • Ay NV, Kh A, Enkhchimeg V, Baatartsogt O. Anti-inflammatory effect of Plantago sp. ethan-olc extract in murine RAW 264.7 macrophage cells. Mongr. J. Agric. Sci. 21: 35-42 (2017)

    Article  Google Scholar 

  • Belsey MA, Sinclair M, Roder MR, LeBlanc DR. Corynebacterium diphtheriae skin infections in Alabama and Louisiana: a factor in the epidemiology of diphtheria. N. Engl. J. Med. 280: 135-141 (1969)

    Article  CAS  Google Scholar 

  • Bocco A, Cuvelier ME, Richard H, Berset C. Antioxidant activity and phenolic composition of citrus peel and seed extracts. J. Agric. Food Chem. 46: 2123-2129 (1998)

    Article  CAS  Google Scholar 

  • Das B, Mandal D, Dash SK, Chattopadhyay S, Tripathy S, Dolai DP, Dey SK, Roy S. Eugenol provokes ROS-mediated membrane damage-associated antibacterial activity against clinically isolated multidrug-resistant Staphylococcus aureus strains. Infect. Dis. (Auckl.). 9: 11-19 (2016)

    Google Scholar 

  • Desai SD, Desai DG, Kaur H. Saponins and their biological activities. Pharm. Times. 41: 13-16 (2009)

    Google Scholar 

  • Emori TG, Gaynes RP. An overview of nosocomial infections, including the role of the microbiology laboratory. Clin. Microbiol. Rev. 6: 428-442 (1993)

    Article  CAS  Google Scholar 

  • Ferrazzano GF, Cantile T, Roberto L, Ingenito A, Catania MR, Roscetto E, Palumbo G, Zarrelli A, Pollio A. Determination of the in vitro and in vivo antimicrobial activity on salivary streptococci and lactobacilli and chemical characterisation of the phenolic content of a Plantago lanceolate infusion. Biomed. Res. Int. 2015: 1-8 (2015)

    Article  Google Scholar 

  • Hemalatha R, Nivetha P, Mohanaproya C, Sharmila G, Muthukumaran C, Gopinath M. Phyrochemical composition, GC-MS analysis, in vitro antioxidant and antibacterial potential of clove flower bud (Eugenia caryophyllus) methanolic extract. J. Food Sci. Technol. 53: 1189-1198 (2016)

    Article  CAS  Google Scholar 

  • Hyun MS, Hur JM, Shin YS, Song BJ, Mun YJ, Woo WH. Comparison study of white ginseng, red ginseng, and fermented red ginseng on the protective effect of LPS-induced inflammation in RAW 264.7 cells. J. Appl. Biol. Chem. 52: 21-27 (2009)

    Article  CAS  Google Scholar 

  • Kim MH, Kim JM, Yoon KY. Effects of blanching on antioxidant activity and total phenolic content according to type of medicinal plants. Food Sci. Biotechnol. 22: 817-823 (2013)

    Article  CAS  Google Scholar 

  • Kubota T, Kitatani H, Hinoh H. The structure of platycogenic acids A, B, and C, further trter-penoid constituents of Platycodon grandiflorum A. De Candolle. J. Chem. Soc. D 19: 1313-1314 (1969)

    Article  Google Scholar 

  • Lee IS, Choi MC, Moon HY. Effect of Platycodon grandiflorum A. DC extract on the bronchus diseases bacteria. Korean J. Biotechnol. Bioeng. 15: 162-166 (2000)

    Google Scholar 

  • Lee WM, Kim SD, Kim KS, Song YB, Kwak YS, Cho JY, Park HJ, Oh JW, Rhee MH. Protopanaxadiol modulates LPS-induced inflammatory activity in murine macrophage RAW 264.7 cells. J. Ginseng. Res. 30: 181-187 (2006)

    Article  CAS  Google Scholar 

  • Leem HH, Kim EO, Seo MJ, Choi SW. Antioxidant and anti-inflammatory activities of eugenol and its derivatives from clove (Eugenia caryophyllata Thunb.). J. Korean Soc. Food Sci. Nutr. 40: 1361-1370 (2011)

    Article  CAS  Google Scholar 

  • Li RW, Theriault AG, Au K, Douglas TD, Casaschi A, Kurowska EM, Mukherjee R. Citrus polymethoxylated flavones improve lipid and glucose homeostasis and modulate adipocytokines in fructose-induced insulin resistant hamsters. Life Sci. 79: 365-373 (2006)

    Article  CAS  Google Scholar 

  • MFDS (Ministry of Food and Drug Safety) and NFSI (National Food Safety Information Service). Information by function of health function food. Available from: https://www.foodsafetykorea.go.kr/

  • Mittal M, Gupta N, Parashar P, Mehra V, Khatri M. Phytochemical evaluation and pharmacological activity of Syzygium aromaticum: a comprehensive review. Int. J. Pharm. Pharm. Sci. 6: 67-72 (2014)

    CAS  Google Scholar 

  • Na IS, Park MJ, Noh CH, Min JW, Bang MH, Yang DC. Production of flavonoid aglycone from Korean Glycyrrhizae radix by biofermentation process. J. Physiol. Pathol. Korean Med. 22: 569-574 (2008)

    Google Scholar 

  • Rafiq S, Kaul R, Sofi SA, Bashir N, Nazir F, Nayik GA. Citrus peel as a source of functional ingredient: a review. J. Saudi Soc. Agric. Sci. 17: 351-358 (2018)

    Google Scholar 

  • Ravn H, Brimer L. Structure and antibacterial activity of plantamajoside, A caffeic acid sugar ester from Plantago major subsp. major. Phytochemistry. 27: 3433-3437 (1988)

    Article  CAS  Google Scholar 

  • Ravn HW, Mondolot L, Kelly MT, Lykke AM. Plantamajoside—a current review. Phytochem. Lett. 12: 42-53 (2015)

    Article  CAS  Google Scholar 

  • Reppert A, Yousef GG, Rogers RB, Lila MA. Isolation of radiolabeled isoflavones from kudzu (Pueraria lobate) root culture. J. Agric. Food Chem. 59: 7860-7865 (2008)

    Article  Google Scholar 

  • Sano K, Sanada S, Ida Y, Shoji J. Studies on the constituents of the bark of Kalopanax pictus Nakai. Chem. Pharm. Bull. 39: 865-870 (1991)

    Article  CAS  Google Scholar 

  • Stevens DL. Invasive group A streptococcus infections. Clin. Infect. Dis. 14: 2-13 (1992)

    Article  CAS  Google Scholar 

  • Stout JE, Koh WJ, Yew WW. Update on pulmonary disease due to non-tuberculous mycobacteria. Int. J. Infect. Dis. 45: 123-134 (2016)

    Article  Google Scholar 

  • Sung WS, Lee DG. The combination effect of Korean Red ginseng saponins with kanamycin and cefotaxime against methicillin-resistant Staphylococcus aureus. Biol. Pharm. Bull. 31: 1614-1617 (2008)

    Article  CAS  Google Scholar 

  • Tanase C, Cosarca S, Muntean DL. A critical review of phenolic compounds extracted from the bark of woody vascular plants and their potential biological activity. Molecules 24: 1182-1199 (2019)

    Article  Google Scholar 

  • Tanemoto R, Okuyama T, Matsuo H, Okumura T, Ikeya Y, Nishizawa M. The constituesnts of licorice (Glycyrrhiza uralensis) differentially suppress nitric oxide production in inerleukin-1β-treated hepatocytes. Biochem. Biophys. Rep. 2: 153-159 (2015)

    PubMed  PubMed Central  Google Scholar 

  • Türel I, Özbek H, Erten R, Öner AC, Cengiz N, Yilmaz O. Hepatoprotective and anti-inflammatory activities of Plantago major L. Indian J. Pharmacol. 41: 120-124 (2009)

    Article  Google Scholar 

  • Wang L, Yang R, Yuan B, Liu Y, Liu C. The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb. Acta. Pharm. Sin. B 5: 310-315 (2015)

    Article  Google Scholar 

  • Watson RR, Preedy VR, Zibadi S. Polyphenols in Human Health and Disease. Academic Press, Cambridge, MA, USA. pp. 253-265 (2014)

    Google Scholar 

  • Xu JG, Liu T, Hu QP, Cao XM. Chemical composition, antibacterial properties and mechanism of action of essential oil from clove buds against Staphylococcus aureus. Molecules 21: 1194-1206 (2016)

    Article  Google Scholar 

Download references

Acknowledgements

This work (Grants No. S2601370) was supported by project for Cooperative R&D between Industry, Academy, and Research Institute funded Korea Ministry of SMEs and Startups in 2018.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jeung-Hee Lee.

Ethics declarations

Conflict of interest

The authors declare no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chang, HJ., Kim, YH., Kang, YH. et al. Antioxidant and antibacterial effects of medicinal plants and their stick-type medicinal concentrated beverages. Food Sci Biotechnol 29, 1413–1423 (2020). https://doi.org/10.1007/s10068-020-00793-9

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10068-020-00793-9

Keywords

Navigation