Abstract
Microfluidic chips have become attractive devices with enormous potential for a wide range of applications. The optimal performances of microfluidic platforms cannot be achieved using a single fabrication technique. The method of obtaining the dominant characteristic of a microfluidic chip is to combine the best qualities of different technological processes and materials. In this paper, we propose a novel, cost-effective, hybrid microfluidic chip manufacturing technologies that combine 3D printing process and xurographic technique. The standard Y-mixer was 3D printed using thermoplastic polymers, while the enclosure of the channel was achieved using the PVC lamination foils. The influence of the fabrication parameters, materials and bonding layers on the channel dimensions, performances and durability in the process of chip realization have been analysed and tested. Optimized parameters have been established for 3D fabrication process. The potential application in biomedicine and material science has been demonstrated on the example with nickel-titanium (NiTi) orthodontic archwire.
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Funding
This research has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 872370, and Province Vojvodina Secretariat for higher education and scientific research for support within the project no. 142-451-2508/2017-04.
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Kojić, S., Birgermajer, S., Radonić, V. et al. Optimization of hybrid microfluidic chip fabrication methods for biomedical application. Microfluid Nanofluid 24, 66 (2020). https://doi.org/10.1007/s10404-020-02372-0
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DOI: https://doi.org/10.1007/s10404-020-02372-0