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A bridge between melanoma cell states

Nature Cell Biology volume 22, pages 913–914 (2020)Cite this article

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Cellular plasticity allows tumours to adapt to and overcome therapeutic challenges. A recent study uncovered the gene regulatory networks that govern cell states and phenotype switching in melanoma, opening up possibilities to therapeutically target cell states or phenotypic plasticity to render melanoma cells more vulnerable to treatment.

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Fig. 1: The most active gene regulatory networks (boxes) are defined as underlying three melanoma cell states (melanocytic, intermediate and mesenchymal).

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  1. Department of Molecular Biology, Princeton University, Princeton, NJ, USA

    Nicole M. Aiello-Couzo & Yibin Kang

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  1. Nicole M. Aiello-Couzo
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  2. Yibin Kang
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Correspondence to Yibin Kang.

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The authors declare no competing interests.

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Aiello-Couzo, N.M., Kang, Y. A bridge between melanoma cell states. Nat Cell Biol 22, 913–914 (2020). https://doi.org/10.1038/s41556-020-0556-2

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