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Iodolopyrazolium Salts – Synthesis, Derivatizations and Applications

03 August 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A fast and reliable synthesis of pyrazole-substituted iodolium triflates is described. Their versatile application as useful synthetic intermediates for straight-forward modifications of pharmaceuticals is demonstrated using Celecoxib as model substrate. Finally, their application as potent halogen-bond donors in a Ritter-type reaction is shown.

Keywords

hypervalent iodine
iodolium
N-heterocycles
halogen-bond donor
Celecoxib

Supplementary materials

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Supporting Information
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Version History

Aug 03, 2020 Version 1

Version Notes

first draft

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License

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CC
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BY
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ND
The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.12746204.v1
D O I: 10.26434/chemrxiv.12746204.v1 [opens in a new tab]

Funding

Fonds der Chemischen Industrie

Author’s competing interest statement

no conflict of interest

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