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Altered resting-state network connectivity in panic disorder: an independent ComponentAnalysis

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Abstract

Panic disorder (PD) is a prevalent anxiety disorder but its neurobiology remains poorly understood. It has been proposed that the pathophysiology of PD is related to an abnormality in a particular neural network. However, most studies investigating resting-state functional connectivity (FC) have relied on a priori restrictions of seed regions, which may bias observations. This study investigated changes in intra and internetwork FC in the whole brain of patients with PD using resting-state functional magnetic resonance imaging. A voxel-wise data-driven independent component analysis was performed on 26 PD patients and 27 healthy controls (HCs).We compared the differences in the intra and internetwork FC between the two groups of subjects using statistical parametric mapping with two-sample t-tests. PD patients exhibited decreased intra-network FC in the right anterior cingulate cortex (ACC) of the anterior default mode network, the left precentral and postcentral gyrus of the sensorimotor network, the right lobule V/VI, the cerebellum vermis, and the left lobule VI of the cerebellum network compared with the HCs. The intra-network FC in the right ACC was negatively correlated with symptom severity. None of the pairs of resting state networks showed significant differences in functional network connectivity between the two groups. These results suggest that the brain networks associated with emotion regulation, interoceptive awareness, and fear and somatosensory processing may play an important role in the pathophysiology of PD.

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Acknowledgements

This study was supported by grants from the National Natural Science Foundation of China (No. 81471720, 81871080, and 81401486).

Funding

This study was supported by grants from the National Natural Science Foundation of China(No. 81471720, 81871080, and 81401486).

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Authors and Affiliations

  1. Department of Radiology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, 110004, China

    Ming-Fei Ni & Xiao-Ming Wang

  2. Department of Radiology, First Affiliated Hospital of Dalian Medical University, No. 222, Zhongshan Road, Xigang District, Dalian, 116011, China

    Ming-Fei Ni

  3. Department of Neurology and Psychiatry, First Affiliated Hospital of Dalian Medical University, No. 222, Zhongshan Road, Xigang District, Dalian, 116011, China

    Bing-Wei Zhang, Yi Chang & Xiao-Feng Huang

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  1. Ming-Fei Ni
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Contributions

Ming-Fei Ni, Bing-Wei Zhang, and Xiao-Ming Wang designed the current study and wrote the manuscript. All authors performed the experiments and analyzed the data. All authors have read and approved the final manuscript.

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Correspondence to Xiao-Ming Wang.

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None of the authors has any financial or personal relationships with people or organizations that could inappropriately influence (bias) this work.

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All procedures performed were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. This study was approved by the Institutional Ethics Committee of the First Affiliated Hospital of Dalian Medical University.

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Ni, MF., Zhang, BW., Chang, Y. et al. Altered resting-state network connectivity in panic disorder: an independent ComponentAnalysis. Brain Imaging and Behavior 15, 1313–1322 (2021). https://doi.org/10.1007/s11682-020-00329-z

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