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An overview of signaling pathways regulating YAP/TAZ activity

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Abstract

YAP and TAZ are ubiquitously expressed homologous proteins originally identified as penultimate effectors of the Hippo signaling pathway, which plays a key role in maintaining mammalian tissue/organ size. Presently, it is known that YAP/TAZ also interact with various non-Hippo signaling pathways, and have diverse roles in multiple biological processes, including cell proliferation, tissue regeneration, cell lineage fate determination, tumorigenesis, and mechanosensing. In this review, we first examine the various microenvironmental cues and signaling pathways that regulate YAP/TAZ activation, through the Hippo and non-Hippo signaling pathways. This is followed by a brief summary of the interactions of YAP/TAZ with TEAD1-4 and a diverse array of other non-TEAD transcription factors. Finally, we offer a critical perspective on how increasing knowledge of the regulatory mechanisms of YAP/TAZ signaling might open the door to novel therapeutic applications in the interrelated fields of biomaterials, tissue engineering, regenerative medicine and synthetic biology.

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Acknowledgments

This work was supported by the National Key R&D Program of China (Grant No. 2018YFC1105303/04), National Natural Science Foundation of China (Grant Nos. 51772006, 31670993, 51973004, 81991505), Beijing Municipal Science & Technology Commission Projects (Grant No. Z181100002018001), and Peking University Medicine Fund (Grant Nos. PKU2020LCXQ009, BMU2020PYB029).

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Authors and Affiliations

  1. Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, People’s Republic of China

    Boon Chin Heng

  2. Faculty of Science and Technology, Sunway University, Selangor Darul Ehsan, Malaysia

    Boon Chin Heng

  3. Department of Dental Materials & Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, 100081, People’s Republic of China

    Xuehui Zhang

  4. IUTA, Departement Genie Biologique, Universite, Claude Bernard Lyon 1, Villeurbanne Cedex, France

    Dominique Aubel

  5. Department of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing, 100081, People’s Republic of China

    Yunyang Bai, Xiaochan Li, Yan Wei & Xuliang Deng

  6. Department of Biosystems Science and Engineering, ETH-Zurich, Mattenstrasse 26, Basel, 4058, Switzerland

    Martin Fussenegger

  7. National Engineering Laboratory for Digital and Material Technology of Stomatology, NMPA Key Laboratory for Dental Materials, Beijing Laboratory of Biomedical Materials, Peking University School and Hospital of Stomatology, Beijing, 100081, People’s Republic of China

    Xuehui Zhang & Xuliang Deng

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  1. Boon Chin Heng
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Boon Chin Heng and Xuehui Zhang contributed equally to this work.

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Heng, B.C., Zhang, X., Aubel, D. et al. An overview of signaling pathways regulating YAP/TAZ activity. Cell. Mol. Life Sci. 78, 497–512 (2021). https://doi.org/10.1007/s00018-020-03579-8

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