Skip to main content
SpringerLink
Log in

Preventive Administration of Melatonin Attenuates Electrophysiological Consequences of Myocardial Ischemia

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

The effect of preventive administration of melatonin on the arrhythmogenic substrate in the myocardium was studied in the rabbit model of acute ischemia/reperfusion in vivo. The animals treated with melatonin 60 min before ischemia induction had shorter median activation time compared to the control group (p=0.039), less pronounced shortening of repolarization durations in the ischemic zone during coronary occlusion (p=0.008), and more complete recovery of repolarization during reperfusion (p=0.027). In the melatonin group, the dispersion of repolarization was less than in the control group during both ischemic period (p=0.043) and reperfusion (p=0.038). Thus, preventive administration of melatonin mitigated the arrhythmogenic substrate in the heart under conditions of ischemia/reperfusion.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Benova T, Viczenczova C, Radosinska J, Bacova B, Knezl V, Dosenko V, Weismann P, Zeman M, Navarova J, Tribulova N. Melatonin attenuates hypertension-related proarrhythmic myocardial maladaptation of connexin-43 and propensity of the heart to lethal arrhythmias. Can. J. Physiol. Pharmacol. 2013;91(8):633-9. doi: https://doi.org/10.1139/cjpp-2012-0393

    Article  CAS  PubMed  Google Scholar 

  2. Benova T, Knezl V, Viczenczova C, Bacova BS, Radosinska J, Tribulova N. Acute anti-fibrillating and defibrillating potential of atorvastatin, melatonin, eicosapentaenoic acid and docosahexaenoic acid demonstrated in isolated heart model. J. Physiol. Pharmacol. 2015;66(1):83-89.

    CAS  PubMed  Google Scholar 

  3. Coronel R, de Bakker JM, Wilms-Schopman FJ, Opthof T, Linnenbank AC, Belterman CN, Janse MJ. Monophasic action potentials and activation recovery intervals as measures of ventricular action potential duration: experimental evidence to resolve some controversies. Heart Rhythm. 2006;3(9):1043-1050

    Article  Google Scholar 

  4. Diez ER, Prados LV, Carrión A, Ponce ZA, Miatello RM. A novel electrophysiologic effect of melatonin on ischemia/reperfusion-induced arrhythmias in isolated rat hearts. J. Pineal Res. 2009;46(2):155-160. doi: https://doi.org/10.1111/j.1600-079X.2008.00643.x

    Article  CAS  PubMed  Google Scholar 

  5. Diez ER, Renna NF, Prado NJ, Lembo C, Ponce Zumino AZ, Vazquez-Prieto M, Miatello RM. Melatonin, given at the time of reperfusion, prevents ventricular arrhythmias in isolated hearts from fructose-fed rats and spontaneously hypertensive rats. J. Pineal Res. 2013;55(2):166-173. doi: https://doi.org/10.1111/jpi.12059

    Article  CAS  PubMed  Google Scholar 

  6. Guide for the Care and Use of Laboratory Animals. Washington, 2011.

  7. Jiki Z, Lecour S, Nduhirabandi F. Cardiovascular Benefits of Dietary Melatonin: A Myth or a Reality? Front. Physiol. 2018;9):528. doi: https://doi.org/10.3389/fphys.2018.00528

  8. Lagneux C, Joyeux M, Demenge P, Ribuot C, Godin-Ribuot D. Protective effects of melatonin against ischemia-reperfusion injury in the isolated rat heart. Life Sci. 2000;66(6):503-509.

    Article  CAS  Google Scholar 

  9. Lee YM, Chen HR, Hsiao G, Sheu JR, Wang JJ, Yen MH. Protective effects of melatonin on myocardial ischemia/reperfusion injury in vivo. J. Pineal Res. 2002;33(2):72-80.

    Article  CAS  Google Scholar 

  10. Prado NJ, Casarotto M, Calvo JP, Mazzei L, Ponce Zumino AZ, García IM, Cuello-Carrión FD, Fornés MW, Ferder L, Diez ER, Manucha W. Antiarrhythmic effect linked to melatonin cardiorenal protection involves AT1 reduction and Hsp70-VDR increase. J. Pineal Res. 2018;65(4). e12513. doi: https://doi.org/10.1111/jpi.12513

    Article  CAS  PubMed  Google Scholar 

  11. Sedova KA, Vaykshnorayte MA, Ovechkin AO, Kneppo P, Bernikova OG, Vityazev VA, Azarov JE. Ventricular electrical heterogeneity in experimental diabetes mellitus: effect of myocardial ischemia. Physiol. Res. 2016;65(3):437-445.

    Article  CAS  Google Scholar 

  12. Tan DX, Manchester LC, Reiter RJ, Qi W, Kim SJ, El-Sokkary GH. Ischemia/reperfusion-induced arrhythmias in the isolated rat heart: prevention by melatonin. J. Pineal Res. 1998;25(3):184-191.

    Article  CAS  Google Scholar 

  13. Vazan R, Pancza D, Béder I, Styk J. Ischemia-reperfusion injury — antiarrhythmic effect of melatonin associated with reduced recovering of contractility. Gen. Physiol. Biophys. 2005;24(3):355-359.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Physiology, Federal Research Center Komi Scientific Centre, Ural Division of Russian Academy of Sciences, Moscow, Russia

    O. G. Bernikova, M. A. Vaykshnorayte, A. O. Ovechkin, S. N. Kharin & J. E. Azarov

  2. Department of Therapy, Pitirim Sorokin Syktyvkar State University, Syktyvkar, Russia

    A. O. Ovechkin

  3. Department of Physiology, Medical Institute, Pitirim Sorokin Syktyvkar State University, Syktyvkar, Russia

    S. N. Kharin & J. E. Azarov

  4. Department of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, Kladno, Czech Republic

    K. A. Sedova

Authors
  1. O. G. Bernikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. A. Vaykshnorayte
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. O. Ovechkin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K. A. Sedova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. N. Kharin
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J. E. Azarov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to O. G. Bernikova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 3, pp. 300-303, March, 2020

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bernikova, O.G., Vaykshnorayte, M.A., Ovechkin, A.O. et al. Preventive Administration of Melatonin Attenuates Electrophysiological Consequences of Myocardial Ischemia. Bull Exp Biol Med 169, 328–331 (2020). https://doi.org/10.1007/s10517-020-04881-y

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-020-04881-y

Key Words

Search

Navigation