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Short Communication: Effects of Dietary Selenium Supplementation on Selenium Deposition and Antioxidant Status in Postpartum Mice

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Abstract

This study aimed to investigate the effects of dietary selenium during pregnancy on the selenium deposition and antioxidant enzymes in postpartum mouse serum, liver, and mammary gland. Eighty BALB/c pregnant mice were randomly divided into four groups: CG (Se-deficient basal diet, n = 20), LG (0.05 mg/kg Se-supplemented diet, n = 20), MG (0.1 mg/kg Se-supplemented diet, n = 20), and HG (0.2 mg/kg Se-supplemented diet, n = 20). Four days after parturition, all mice were euthanized. The selenium deposition and antioxidants enzymes in serum, liver, and mammary gland were detected. Results show that with increasing selenium supplementation, the selenium deposition and activation of T-AOC, T-SOD, and GSH-Px increased, meanwhile the concentration of MDA decreased in serum, liver, and mammary gland. Therefore, this study suggested selenium was mainly deposited in the liver, and dietary selenium during pregnancy might improve the antioxidant status in postpartum animals.

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Data Availability

All data used during the study appear in the submitted article.

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Funding

This work was supported by the Science and Technology Project of Shandong Province Higher Education Institutions (J18KB074), the National Natural Science Foundation of China (No. 31802254), and the Key Research and Development Project of Hebei (19226625D).

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Authors and Affiliations

  1. College of Agriculture and Forestry Science, Linyi University, Shuangling Road, Linyi City, 276005, Shandong Province, China

    Zhen-Nan Wang, Hui Li, He Tang, Shu-Jiu Zhang & Chong-Liang Bi

  2. Department of Pediatrics, University of Alberta, Edmonton, Alberta, T6G 2R3, Canada

    Mirielle Pauline

Authors
  1. Zhen-Nan Wang
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  2. Hui Li
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  3. He Tang
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  4. Shu-Jiu Zhang
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  5. Mirielle Pauline
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  6. Chong-Liang Bi
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Contributions

Chong-Liang Bi contributed to the overall study design and supervised all research. Zhen-Nan Wang carried out the experiments, and analyzed the data and was also responsible for the final editing of the manuscript. Hui Li prepared the figures. Shu-Jiu Zhang contributed partly to the writing and finally revising the manuscript and data analysis. He Tang drafted and revised the first version of the manuscript. Mirielle Pauline contributed to language editing. All the authors reviewed and finally approved the manuscript.

Corresponding author

Correspondence to Chong-Liang Bi.

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Ethical Approval

All experimental procedures were conducted with the approval of the Institutional Animal Care and Use Committee of Linyi University (Approval ID: [2006], 24).

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The authors declare that they have no conflict of interest.

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Wang, ZN., Li, H., Tang, H. et al. Short Communication: Effects of Dietary Selenium Supplementation on Selenium Deposition and Antioxidant Status in Postpartum Mice. Biol Trace Elem Res 199, 1488–1492 (2021). https://doi.org/10.1007/s12011-020-02260-2

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  • DOI: https://doi.org/10.1007/s12011-020-02260-2

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