Abstract
A strategy for amplifying the signal of surface plasmon resonance (SPR) biosensors is reported. Biotinylated phenylalanine (Biotin-Phe) monomers were rapidly self-assembled into nanoparticles in a mild environment. The self-assembled nanoparticles were then used as the carriers of streptavidin-antibody complexes by the streptavidin-biotin interaction. The signal was amplified because of the high molecular weight of the nanoparticle-streptavidin-antibody conjugate. With prostate-specific antigen as a model analyte, the target concentration as low as 1 pg mL−1 was readily measured. The results of the nanoparticle-enhanced SPR biosensor for analysis of serum samples are well consistent with those achieved by the enzyme-linked immunosorbent assays. This work is valuable for designing of various optical and electronic biosensors through the streptavidin-biotin interaction.
Similar content being viewed by others
References
Wu L, Qu X (2015) Cancer biomarker detection: recent achievements and challenges. Chem Soc Rev 44:2963–2997
Ghorbani F, Abbaszadeh H, Mehdizadeh A, Ebrahimi-Warkiani M, Rashidi MR, Yousefi M (2019) Biosensors and nanobiosensors for rapid detection of autoimmune diseases: a review. Microchim Acta 186:838
Li P, Huang Z, She Y, Qin S, Gao W, Cao Y, Liu X (2020) An assessment of the interaction for three Chrysanthemum indicum flavonoids and alpha-amylase by surface plasmon resonance. Food Sci Nutr 8:620–628
Huang X, Hu X, Song S, Mao D, Lee J, Koh K, Zhu Z, Chen H (2020) Triple-enhanced surface plasmon resonance spectroscopy based on cell membrane and folic acid functionalized gold nanoparticles for dual-selective circulating tumor cell sensing. Sensors Actuators B Chem 305:127543
Karoonuthaisiri N, Charlermroj R, Morton MJ, Oplatowska-Stachowiak M, Grant IR, Elliott C (2014) Development of a M13 bacteriophage-based SPR detection using Salmonella as a case study. Sensors Actuators B Chem 190:214–220
Mayang Y, He X, Chen L, Zhang Y (2017) Detection of transferrin by using a surface plasmon resonance sensor functionalized with a boronic acid monolayer. Microchim Acta 184:2749–2757
Śípová H, Homola J (2013) Surface plasmon resonance sensing of nucleic acids: a review. Anal Chim Acta 773:9–23
Kim S, Lee HJ (2017) Gold nanostar enhanced surface plasmon resonance detection of an antibiotic at attomolar concentrations via an aptamer-antibody sandwich assay. Anal Chem 89:6624–6630
Zeng K, Li H, Peng Y (2017) Gold nanoparticle enhanced surface plasmon resonance imaging of microRNA-155 using a functional nucleic acid-based amplification machine. Microchim Acta 184:2637–2644
Chen F, Wu Q, Song D, Wang X, Ma P, Sun Y (2019) Fe3O4@PDA immune probe-based signal amplification in surface plasmon resonance (SPR) biosensing of human cardiac troponin I. Colloids Surf B Biointerfaces 177:105–111
Zeng S, Baillargeat D, Ho H-P, Yong K-T (2014) Nanomaterials enhanced surface plasmon resonance for biological and chemical sensing applications. Chem Soc Rev 43:3426–3452
Dong H, Zou F, Hu X, Zhu H, Koh K, Chen H (2018) Analyte induced AuNPs aggregation enhanced surface plasmon resonance for sensitive detection of paraquat. Biosens Bioelectron 117:605–612
Tabasi O, Falamaki C (2018) Recent advancements in the methodologies applied for the sensitivity enhancement of surface plasmon resonance sensors. Anal Methods 10:3906–3925
Damborsk D, Bertok T, Dosekov E, Holazov A, Lorencov L, Kasak P, Tkac J (2017) Nanomaterial-based biosensors for detection of prostate specific antigen. Microchim Acta 184:3049–3067
Kim H-M, Park J-H, Jeong DH, Lee H-Y, Lee S-K (2018) Real-time detection of prostate-specific antigens using a highly reliable fiber-optic localized surface plasmon resonance sensor combined with micro fluidic channel. Sensors Actuators B Chem 273:891–898
Li Q, Dou X, Zhang L, Zhao X, Luo J, Yang M (2019) Oriented assembly of surface plasmon resonance biosensor through staphylococcal protein A for the chlorpyrifos detection. Anal Bioanal Chem 411:6057–6066
Śípová H, Springer T, Homola J (2011) Streptavidin-enhanced assay for sensitive and specific detection of single nucleotide polymorphism in TP53. Anal Bioanal Chem 399:2343–2350
Zhang D, Yan Y, Cheng W, Zhang W, Li Y, Ju H, Ding S (2013) Streptavidin-enhanced surface plasmon resonance biosensor for highly sensitive and specific detection of microRNA. Microchim Acta 180:397–403
Yi X, Hao Y, Xia N, Wang J, Quintero M, Li D, Zhou F (2013) Sensitive and continuous screening of inhibitors of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) at single SPR chips. Anal Chem 85:3660–3666
Xia N, Liu L, Harrington MG, Wang J, Zhou F (2010) Regenerable and simultaneous surface plasmon resonance detection of abeta(1-40) and abeta(1-42) peptides in cerebrospinal fluids with signal amplification by streptavidin conjugated to an N-terminus-specific antibody. Anal Chem 82:10151–10157
Dubacheva GV, Araya-Callis C, Volbeda AG, Fairhead M, Codeé J, Howarth M, Richter RP (2017) Controlling multivalent binding through surface chemistry: model study on streptavidin. J Am Chem Soc 139:4157–4167
Lei P, Tang H, Ding S, Ding X, Zhu D, Shen B, Cheng Q, Yan Y (2015) Determination of the invA gene of Salmonella using surface plasmon resonance along with streptavidin aptamer amplification. Microchim Acta 182:289–296
Fleming S, Ulijn RV (2014) Design of nanostructures based on aromatic peptide amphiphiles. Chem Soc Rev 43:8150–8177
Yan X, Zhu P, Li J (2010) Self-assembly and application of diphenylalanine-based nanostructures. Chem Soc Rev 39:1877–1890
Kausaite-Minkstimiene A, Ramanaviciene A, Kirlyte J, Ramanavicius A (2010) Comparative study of random and oriented antibody immobilization techniques on the binding capacity of immunosensor. Anal Chem 82:6401–6408
Rath D, Kumar S, Panda S (2019) pH-based detection of target analytes in diluted serum samples using surface plasmon resonance immunosensor. Appl Biochem Biotechnol 187:1272–1284
Jiang Z, Qin Y, Peng Z, Chen S, Chen S, Deng C, Xiang J (2014) The simultaneous detection of free and total prostate antigen in serum samples with high sensitivity and specificity by using the dual-channel surface plasmon resonance. Biosens Bioelectron 62:268–273
Ertürk G, Özen H, Aşkın Tümer M, Mattiasson B, DenizliöÜ A (2016) Microcontact imprinting based surface plasmon resonance (SPR) biosensor for real-time and ultrasensitive detection of prostate specific antigen (PSA) from clinical samples. Sensors Actuators B Chem 224:823–832
Jung J, Na K, Lee J, Kim KW, Hyuna J (2009) Enhanced surface plasmon resonance by Au nanoparticles immobilized on a dielectric SiO2 layer on a gold surface. Anal Chim Acta 651:91–97
Wang W, Zhu X, Teng S, Xu X, Zhou G (2018) Development and validation of a surface plasmon resonance biosensor for specific detection of porcine serum albumin in food. J AOAC Int 101:1868–1872
Uludag Y, Tothill IE (2012) Cancer biomarker detection in serum samples using surface plasmon resonance and quartz crystal microbalance sensors with nanoparticle signal amplification. Anal Chem 84:5898–5904
Choi J-W, Kang D-Y, Jang Y-H, Kim H-H, Min J, Oh B-K (2008) Ultra-sensitive surface plasmon resonance based immunosensor for prostate-specific antigen using gold nanoparticle–antibody complex. Colloids Surf A Physicochem Eng Asp 313-314:655–659
Huang L, Reekmans G, Saerens D, Friedt JM, Frederix F, Francis L, Muyldermans S, Campitelli A, Van Hoof C (2005) Prostate-specific antigen immunosensing based on mixed self-assembled monolayers, camel antibodies and colloidal gold enhanced sandwich assays. Biosens Bioelectron 21:483–490
Besselink GAJ, Kooyman RPH, van Os PJHJ, Engbers GHM, Schasfoort RBM (2004) Signal amplification on planar and gel-type sensor surfaces in surface on planar and gel-type sensor surfaces in surface plasmon resonance-based detection of prostate-specific antigen. Anal Biochem 333:165–173
Funding
Partial support of this work was provided by the National Natural Science Foundation of China (21804002), the First Class Discipline-Chemistry of Guizhou Education University (2019YLXKB03), the Guizhou Education University Doctor Program (2019BS008), and the Research Funds for the Henan Key Laboratory of Biomolecular Recognition and Sensing (HKLBRSK1902).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Conflict of interest
The author(s) declare that they have no competing interests.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Electronic supplementary material
ESM 1
(DOCX 2135 kb)
Rights and permissions
About this article
Cite this article
Sun, T., Zhang, Y., Zhao, F. et al. Self-assembled biotin-phenylalanine nanoparticles for the signal amplification of surface plasmon resonance biosensors. Microchim Acta 187, 473 (2020). https://doi.org/10.1007/s00604-020-04461-x
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s00604-020-04461-x