Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

TUMOR IMMUNOLOGY

NRP1 cripples immunological memory

Nature Immunology volume 21, pages 972–973 (2020)Cite this article

Subjects

Durable responses to immunotherapy require the development of robust CD8+ T cell memory. A new study indicates that NRP1 differs from other checkpoint receptors as it functions as a checkpoint for the generation of memory.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: NRP1 acts as a checkpoint for the generation of T cell memory.

References

  1. Liu, C. et al. Nat. Immunol. https://doi.org/10.1038/s41590-020-0733-2 (2020).

  2. Overacre-Delgoffe, A. E. et al. Cell 169, 1130–1141.e11 (2017).

    Article  CAS  Google Scholar 

  3. Leclerc, M. et al. Nat. Commun. 10, 3345 (2019).

    Article  Google Scholar 

  4. Wherry, E. J. Nat Immunol 12, 492–499 (2011).

    Article  CAS  Google Scholar 

  5. Hwang, J. Y., Sun, Y., Carroll, C. R. & Usherwood, E. J. Msphere 4, e00221–19 (2019).

    Article  CAS  Google Scholar 

  6. Im, S. J. et al. Nature 537, 417–421 (2016).

    Article  CAS  Google Scholar 

  7. Sade-Feldman, M. et al. Cell 175, 998–1013.e20 (2018).

    Article  CAS  Google Scholar 

  8. Siddiqui, I. et al. Immunity 50, 195–211.e10 (2019).

    Article  CAS  Google Scholar 

  9. Kurtulus, S. et al. Immunity 50, 181–194.e6 (2019).

    Article  CAS  Google Scholar 

  10. Miller, B. C. et al. Nat. Immunol. 20, 326–336 (2019).

    Article  CAS  Google Scholar 

  11. Utzschneider, D. T. et al. Immunity 45, 415–427 (2016).

    Article  CAS  Google Scholar 

  12. Zhou, X. et al. Immunity 33, 229–240 (2010).

    Article  CAS  Google Scholar 

  13. Yang, C. Y. et al. Nat Immunol 12, 1221–1229 (2011).

    Article  CAS  Google Scholar 

  14. Lynn, R. C. et al. Nature 576, 293–300 (2019).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA

    Nandini Acharya & Ana C. Anderson

Authors
  1. Nandini Acharya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ana C. Anderson
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ana C. Anderson.

Ethics declarations

Competing interests

A.C.A. is a member of the SAB for Tizona Therapeutics, Compass Therapeutics, Zumutor Biologics, ImmuneOncia and Astellas Global Pharma Development Inc., which have interests in cancer immunotherapy. A.C.A.’s interests were reviewed and managed by the Brigham and Women’s Hospital and Partners Healthcare in accordance with their conflict of interest policies.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Acharya, N., Anderson, A.C. NRP1 cripples immunological memory. Nat Immunol 21, 972–973 (2020). https://doi.org/10.1038/s41590-020-0759-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-020-0759-5

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer