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Facile Synthesis of Ultrasmall, Highly Stable, and Biocompatible Gold Nanoparticles Stabilized with Lipoic Acid: Cytotoxicity and Structural Characterization

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Abstract—

Using the colloidal method, and lipoic acid as a stabilizer, ultrasmall gold nanoparticles with an average size of 2.5 nm were synthesized. They are highly stable, have COOH functional groups, at concentrations lower than 100 μg/mL are non-cytotoxic, and the synthesis route is simple and economical. UV–Vis, FT-IR, Raman, and TEM spectroscopy were used to analyze their stability, composition and morphology. Furthermore, the cytotoxicity of the gold nanoparticles was evaluated by MTT assay.

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ACKNOWLEDGMENTS

The authors are indebted to Dr. M. Pérez-González, S.A. Tomás, and Dr. Genoveva Hernández-Padrón for their technical support.

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Authors and Affiliations

  1. Universidad Autónoma de Ciudad Juárez, Colonia Partido Romero, C.P. 32310, Juárez, Chihuahua, México

    Delfino Cornejo-Monroy, Betania Sánchez-Santamaria, Erwin Adán Martínez-Gómez, Imelda Olivas-Armendáriz & Alfredo Villanueva-Montellano

  2. Centro de Investigación y de Estudios Avanzados del I.P.N., C.P. 07360, San Pedro Zacatenco, Ciudad de México, México

    José Saúl Arias-Cerón

  3. Universidad Nacional Autónoma de México, Querétaro, C.P. 76230, Querétaro, México

    Victor M. Castaño

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  1. Delfino Cornejo-Monroy
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  2. Betania Sánchez-Santamaria
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Correspondence to Victor M. Castaño.

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Cornejo-Monroy, D., Sánchez-Santamaria, B., Martínez-Gómez, E.A. et al. Facile Synthesis of Ultrasmall, Highly Stable, and Biocompatible Gold Nanoparticles Stabilized with Lipoic Acid: Cytotoxicity and Structural Characterization. Nanotechnol Russia 14, 607–612 (2019). https://doi.org/10.1134/S199507801906003X

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  • DOI: https://doi.org/10.1134/S199507801906003X

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