Skip to main content
SpringerLink
Log in

Systematic review and meta-analysis of association of polymorphisms in inflammatory cytokine genes with coronary artery disease

  • Review
  • Published:
Inflammation Research Aims and scope Submit manuscript

Abstract

Background

It has comprehensively been acknowledged that a genetic contribution, especially in immune inflammatory players, such as interleukin (IL)-6 and tumor necrosis factor (TNF)-α, are critically involved in the pathophysiology of coronary artery disease (CAD). This meta-analysis study aimed to reach a conclusive understanding of the role of genetic polymorphisms, including IL6 gene C572G (rs1800796) and G174C (rs1800795) as well as TNFA gene G238A (rs361525) and G308A (rs1800629) in susceptibility to CAD.

Methods

Two major databases, namely MEDLINE and Scopus, were searched to find the studies surveying the mentioned polymorphisms and CAD susceptibility up to July 2020. Association comparison between the polymorphisms and CAD susceptibility were assessed using pooled odds ratio (OR) and their corresponding 95% confidence interval (CI).

Results

This meta-analysis study was conducted on 69 papers (73 population studies), comprising 5062 patients and 8446 controls for IL6 gene rs1800796 (17 studies), 13801 patients and 16215 controls for IL6 gene rs1800795 (38 studies), 1439 patients and 2850 controls for TNFA gene rs361525 (5 studies), and 5051 patients and 3958 controls for TNFA gene rs1800629 (13 studies), according to inclusion and exclusion criteria. There were statistically positive association between all genetic comparisons of IL6 gene rs1800795 polymorphism and the CAD risk. Moreover, the recessive model (CC vs. CG + GG) in IL6 gene rs1800796 polymorphism had marginally significant association with decreased risk of CAD. None of the TNFA gene polymorphisms were associated with CAD risk.

Conclusions

The meta-analysis revealed the positive association of IL6 gene rs1800795 polymorphism in susceptibility to CAD.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

Availability of data and material

The data that support the findings of this study are available on request from the corresponding author. All data generated or analyzed during this study are included in this published article.

Abbreviations

IL:

Interleukin

TNF:

Tumor necrosis factor

CAD:

Coronary artery disease

OR:

Odds ratio

CI:

Confidence interval

SNPs:

Single nucleotide polymorphisms

MHC:

Major histocompatibility complex

PRISMA:

Preferred reporting items for systematic reviews and meta-analyses

References

  1. Harky A, Noshirwani A, Karadakhy O, Ang J. Comprehensive literature review of anomalies of the coronary arteries. J Cardiac Surg. 2019;34(11):1328–43.

    Google Scholar 

  2. Figura N, Palazzuoli A, Vaira D, Campagna M, Moretti E, Iacoponi F, et al. Cross-sectional study: CagA–positive Helicobacter pylori infection, acute coronary artery disease and systemic levels of B-type natriuretic peptide. J Clin Pathol. 2014;67:251–7.

    CAS  PubMed  Google Scholar 

  3. Jia S-J, Niu P-P, Cong J-Z, Zhang B-K, Zhao M. TLR4 signaling: a potential therapeutic target in ischemic coronary artery disease. Int Immunopharmacol. 2014;23:54–9.

    CAS  PubMed  Google Scholar 

  4. Sanjadi M, Rezvanie Sichanie Z, Totonchi H, Karami J, Rezaei R, Aslani S. Atherosclerosis and autoimmunity: a growing relationship. Int J Rheum Dis. 2018;21:908–21.

    PubMed  Google Scholar 

  5. Yeganeh F, Mousavi SMJ, Hosseinzadeh-Sarband S, Ahmadzadeh A, Bahrami-Motlagh H, Hoseini MHM, et al. Association of CD26/dipeptidyl peptidase IV mRNA level in peripheral blood mononuclear cells with disease activity and bone erosion in rheumatoid arthritis. Clin Rheumatol. 2018;37:3183–90.

    PubMed  Google Scholar 

  6. Said MA, van de Vegte YJ, Zafar MM, van der Ende MY, Raja GK, Verweij N, et al. Contributions of interactions between lifestyle and genetics on coronary artery disease risk. Curr Cardiol Rep. 2019;21:89.

    PubMed  PubMed Central  Google Scholar 

  7. Mahalle N, Garg M, Kulkarni M, Naik S. Association of inflammatory cytokines with traditional and nontraditional cardiovascular risk factors in indians with known coronary artery disease. Ann Med Health Sci Res. 2014;4:706–12.

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Ghazouani L, Abboud N, Khalifa SBH, Added F, Khalfallah AB, Nsiri B, et al. 174G > C interleukin-6 gene polymorphism in Tunisian patients with coronary artery disease. Ann Saudi Med. 2011;31:40–4.

    PubMed  PubMed Central  Google Scholar 

  9. Masafi S, Saadat SH, Tehranchi K, Olya R, Heidari M, Malihialzackerini S, et al. Effect of stress, depression and type D personality on immune system in the incidence of coronary artery disease. Open Access Macedonian J Med Sci. 2018;6:1533.

    Google Scholar 

  10. Terry CF, Loukaci V, Green FR. Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. J Biol Chem. 2000;275:18138–44.

    CAS  PubMed  Google Scholar 

  11. Karahan ZC, Deda G, Sipahi T, Elhan AH, Akar N. TNF-α − 308G/A and IL-6 − 174 G/C polymorphisms in the Turkish pediatric stroke patients. Thromb Res. 2005;115:393–8.

    CAS  PubMed  Google Scholar 

  12. Kelberman D, Hawe E, Luong LA, Mohamed-Ali V, Lundman P, Tornvall P, et al. Effect of Interleukin-6 promoter polymorphisms in survivors of myocardial infarction and matched controls in the North and South of Europe. Thromb Haemost. 2004;92:1122–8.

    CAS  PubMed  Google Scholar 

  13. Kou L, Yang N, Dong B, Li Y, Yang J, Qin Q. Interaction between SELP genetic polymorphisms with inflammatory cytokine interleukin-6 (IL-6) gene variants on cardiovascular disease in Chinese Han population. Mamm Genome. 2017;28:436–42.

    CAS  PubMed  Google Scholar 

  14. Lalouschek W, Schillinger M, Hsieh K, Endler G, Greisenegger S, Marculescu R, et al. Polymorphisms of the inflammatory system and risk of ischemic cerebrovascular events. Clin Chem Lab Med (CCLM). 2006;44:918–23.

    CAS  Google Scholar 

  15. Satti HS, Hussain S, Javed Q. Association of interleukin-6 gene promoter polymorphism with coronary artery disease in Pakistani families. Sci World J. 2013. https://doi.org/10.1155/2013/538365.

    Article  Google Scholar 

  16. Sekuri C, Cam FS, Sagcan A, Ercan E, Tengiz I, Alioglu E, et al. No association of interleukin-6 gene polymorphism (-174 G/C) with premature coronary artery disease in a Turkish cohort. Coron Artery Dis. 2007;18:333–7.

    PubMed  Google Scholar 

  17. Sie MP, Sayed-Tabatabaei FA, Oei H-HS, Uitterlinden AG, Pols HA, Hofman A, et al. Interleukin 6–174 g/c promoter polymorphism and risk of coronary heart disease: results from the rotterdam study and a meta-analysis. Arterioscl Thromb Vasc Biol. 2006;26:212–7.

    CAS  PubMed  Google Scholar 

  18. Song H, Zhou X, Guo L, Tian F, Guo X, Sun Y. Association of phosphodiesterase 4D gene and interleukin-6 receptor gene polymorphisms with ischemic stroke in a Chinese hypertensive population. Genet Mol Res. 2015;14:19396–403.

    CAS  PubMed  Google Scholar 

  19. Koch W, Tiroch K, von Beckerath N, Schömig A, Kastrati A. Tumor necrosis factor-α, lymphotoxin-α, and interleukin-10 gene polymorphisms and restenosis after coronary artery stenting. Cytokine. 2003;24:161–71.

    CAS  PubMed  Google Scholar 

  20. Allen R, Lee E, Roberts D, Park B, Pirmohamed M. Polymorphisms in the TNF-α and TNF-receptor genes in patients with coronary artery disease. Eur J Clin Invest. 2001;31:843–51.

    CAS  PubMed  Google Scholar 

  21. Hou L, Huang J, Lu X, Wang L, Fan Z, Gu D. Polymorphisms of tumor necrosis factor alpha gene and coronary heart disease in a Chinese Han population: interaction with cigarette smoking. Thromb Res. 2009;123:822–6.

    CAS  PubMed  Google Scholar 

  22. Allen RD. Polymorphism of the human TNF-α promoter—random variation or functional diversity? Mol Immunol. 1999;36:1017–27.

    CAS  PubMed  Google Scholar 

  23. Wang XL, Oosterhof J. Tumour necrosis factor α G − 308 → A polymorphism and risk for coronary artery disease. Clin Sci. 2000;98:435–7.

    CAS  Google Scholar 

  24. Cheng Y, An B, Jiang M, Xin Y, Xuan S. Association of tumor necrosis factor-alpha polymorphisms and risk of coronary artery disease in patients with non-alcoholic fatty liver disease. Hepatitis Monthly. 2015;15(3):e26818.

    PubMed  PubMed Central  Google Scholar 

  25. Shih C-M, Lee Y-L, Chiou H-L, Chen W, Chang G-C, Chou M-C, et al. Association of TNF-α polymorphism with susceptibility to and severity of non-small cell lung cancer. Lung Cancer. 2006;52:15–20.

    PubMed  Google Scholar 

  26. Fan H-M, Wang Z, Feng F-M, Zhang K-L, Yuan J-X, Sui H, et al. Association of TNF-α-238G/A and 308 G/A gene polymorphisms with pulmonary tuberculosis among patients with coal worker’s pneumoconiosis. Biomed Environ Sci. 2010;23:137.

    CAS  PubMed  Google Scholar 

  27. Jk Wang, Zw Feng, Yc Li, Qy Li, Xy Tao. Association of tumor necrosis factor-α gene promoter polymorphism at sites-308 and-238 with non-alcoholic fatty liver disease: a meta-analysis. J Gastroenterol Hepatol. 2012;27:670–6.

    Google Scholar 

  28. Cui G, Wang H, Li R, Zhang L, Li Z, Wang Y, et al. Polymorphism of tumor necrosis factor alpha (TNF-alpha) gene promoter, circulating TNF-alpha level, and cardiovascular risk factor for ischemic stroke. J Neuroinflam. 2012;9:235.

    CAS  Google Scholar 

  29. Banerjee I, Pandey U, Hasan OM, Parihar R, Tripathi V, Ganesh S. Association between inflammatory gene polymorphisms and coronary artery disease in an Indian population. J Thromb Thrombolysis. 2009;27:88–94.

    CAS  PubMed  Google Scholar 

  30. Herrmann S, Ricard S, Nicaud V, Mallet C, Arveiler D, Evans A, et al. Polymorphisms of the tumour necrosis factor-alpha gene, coronary heart disease and obesity. Eur J Clin Invest. 1998;28:59–66.

    CAS  PubMed  Google Scholar 

  31. Cho H-C, Yu G, Lee M-Y, Kim H-S, Shin D-H, Kim Y-N. TNF-α polymorphisms and coronary artery disease: association study in the Korean population. Cytokine. 2013;62:104–9.

    CAS  PubMed  Google Scholar 

  32. Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4:1.

    PubMed  PubMed Central  Google Scholar 

  33. Huedo-Medina TB, Sánchez-Meca J, Marín-Martínez F, Botella J. Assessing heterogeneity in meta-analysis: Q statistic or I2 index? Psychol Methods. 2006;11:193.

    PubMed  Google Scholar 

  34. MartorellMarugan J, ToroDominguez D, AlarconRiquelme ME, CarmonaSaez PJBB. MetaGenyo: a web tool for meta-analysis of genetic association studies. BMC Bioinform. 2017;18:563.

    Google Scholar 

  35. Piira O-P, Miettinen JA, Hautala AJ, Huikuri HV, Tulppo MP. Physiological responses to emotional excitement in healthy subjects and patients with coronary artery disease. Autonomic Neurosci. 2013;177:280–5.

    Google Scholar 

  36. Mayyas FA, Al-Jarrah MI, Ibrahim KS, Alzoubi KH. Level and significance of plasma myeloperoxidase and the neutrophil to lymphocyte ratio in patients with coronary artery disease. Exp Ther Med. 2014;8:1951–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  37. Anderson DR, Poterucha JT, Mikuls TR, Duryee MJ, Garvin RP, Klassen LW, et al. IL-6 and its receptors in coronary artery disease and acute myocardial infarction. Cytokine. 2013;62:395–400.

    CAS  PubMed  Google Scholar 

  38. Smith AJ, D’Aiuto F, Palmen J, Cooper JA, Samuel J, Thompson S, et al. Association of serum interleukin-6 concentration with a functional IL6− 6331T> C polymorphism. Clin Chem. 2008;54:841–50.

    CAS  PubMed  Google Scholar 

  39. Yin Y-W, Li J-C, Zhang M, Wang J-Z, Li B-H, Liu Y, et al. Influence of interleukin-6 gene − 174G > C polymorphism on development of atherosclerosis: a meta-analysis of 50 studies involving 33,514 subjects. Gene. 2013;529:94–103.

    CAS  PubMed  Google Scholar 

  40. Hou H, Wang C, Sun F, Zhao L, Dun A, Sun Z. Association of interleukin-6 gene polymorphism with coronary artery disease: an updated systematic review and cumulative meta-analysis. Inflamm Res. 2015;64:707–20.

    CAS  PubMed  Google Scholar 

  41. González-Castro TB, Hernández-Díaz Y, Pérez-Hernández N, Tovilla-Zárate CA, Juárez-Rojop IE, López-Narvaez ML, et al. Interleukin 6 (rs1800795) gene polymorphism is associated with cardiovascular diseases: a meta-analysis of 74 studies with 86,229 subjects. EXCLI J. 2019;18:331.

    PubMed  PubMed Central  Google Scholar 

  42. Song C, Liu B, Yang D, Diao H, Zhao L, Lu Y, et al. Association between interleukin-6 gene − 572G > C polymorphism and coronary heart disease. Cell Biochem Biophys. 2015;71:359–65.

    CAS  PubMed  Google Scholar 

  43. Asifa GZ, Liaquat A, Murtaza I, Kazmi SAR, Javed Q. Tumor necrosis factor-alpha gene promoter region polymorphism and the risk of coronary heart disease. Sci World J. 2013. https://doi.org/10.1155/2013/203492.

    Article  Google Scholar 

  44. Zhang H-F, Zhong B-L, Zhu W-L, Xie S-L, Qiu L-X, Zhu L-G, et al. CD14 C-260T gene polymorphism and ischemic heart disease susceptibility: a HuGE review and meta-analysis. Genet Med. 2009;11:403.

    CAS  PubMed  Google Scholar 

  45. Pulido-Gómez K, Hernández-Díaz Y, Tovilla-Zárate CA, Juárez-Rojop IE, González-Castro TB, López-Narváez ML, et al. Association of G308A and G238A polymorphisms of the TNF-α gene with risk of coronary heart disease: systematic review and meta-analysis. Arch Med Res. 2016;47:557–72.

    PubMed  Google Scholar 

  46. Georges J-L, Loukaci V, Poirier O, Evans A, Luc G, Arveiler D, et al. Interleukin-6 gene polymorphisms and susceptibility to myocardial infarction: the ECTIM study. J Mol Med. 2001;79:300–5.

    CAS  PubMed  Google Scholar 

  47. Humphries S, Luong L, Ogg M, Hawe E, Miller G. The interleukin-6 − 174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men. Eur Heart J. 2001;22:2243–52.

    CAS  PubMed  Google Scholar 

  48. Basso F, Lowe GD, Rumley A, McMahon AD, Humphries SE. Interleukin-6 − 174G > C polymorphism and risk of coronary heart disease in West of Scotland coronary prevention study (WOSCOPS). Arterioscler Thromb Vasc Biol. 2002;22:599–604.

    CAS  PubMed  Google Scholar 

  49. Bennet AM, Prince JA, Fei G-Z, Lyrenäs L, Huang Y, Wiman B, et al. Interleukin-6 serum levels and genotypes influence the risk for myocardial infarction. Atherosclerosis. 2003;171:359–67.

    CAS  PubMed  Google Scholar 

  50. Fu H, Li G, Li Y, Xu J, Zhang J. Interleukin-6-597G/A and-572C/G polymorphisms and risk of coronary heart disease. Zhonghua Xin Xue Guan Bing Za Zhi. 2006;34:519–22.

    CAS  PubMed  Google Scholar 

  51. Park S, Youn J-C, Shin D-J, Park C-M, Kim J-S, Ko Y-G, et al. Genetic polymorphism in the pregnancy-associated plasma protein—a associated with acute myocardial infarction. Coron Artery Dis. 2007;18:417–22.

    PubMed  Google Scholar 

  52. Fan W, Liu D, Xiao L, Xie C, Sun S, Zhang J. Coronary heart disease and chronic periodontitis: is polymorphism of interleukin-6 gene the common risk factor in a Chinese population? Oral Dis. 2011;17:270–6.

    CAS  PubMed  Google Scholar 

  53. Jia X, Tian Y, Wang Y, Deng X, Dong Z, Scafa N, et al. Association between the interleukin-6 gene-572G/C and-597G/A polymorphisms and coronary heart disease in the Han Chinese. Med Sci Mon. 2010;16:103–8.

    Google Scholar 

  54. Çoker A, Arman A, Soylu O, Tezel T, Yildirim A. Lack of association between IL-1 and IL-6 gene polymorphisms and myocardial infarction in Turkish population. Int J Immunogenet. 2011;38:201–8.

    PubMed  Google Scholar 

  55. Li L, Li E, Zhang L, Jian L, Liu H, Wang T. IL-6-174G/C and IL-6-572C/G polymorphisms are associated with increased risk of coronary artery disease. Genet Mol Res. 2015;14:8451–7.

    CAS  PubMed  Google Scholar 

  56. Jabir NR, Firoz CK, Kamal MA, Damanhouri GA, Alama MN, Alzahrani AS, et al. Assessment of genetic diversity in IL-6 and RANTES promoters and their level in Saudi coronary artery disease patients. J Clin Lab Anal. 2017;31:e22092.

    Google Scholar 

  57. Mao L, Geng GY, Han WJ, Zhao MH, Wu L, Liu HL. Interleukin-6 (IL-6) -174G/C genomic polymorphism contribution to the risk of coronary artery disease in a Chinese population. Genet Mol Res. 2016;196:15–43.

    Google Scholar 

  58. Mitrokhin V, Nikitin A, Brovkina O, Khodyrev D, Zotov A, Vachrushev N, et al. Association between interleukin-6/6R gene polymorphisms and coronary artery disease in Russian population: influence of interleukin-6/6R gene polymorphisms on inflammatory markers. J Inflamm Res. 2017;10:151.

    CAS  PubMed  PubMed Central  Google Scholar 

  59. Chen H, Ding S, Liu X, Wu Y, Wu X. Association of interleukin-6 genetic polymorphisms and environment factors interactions with coronary artery disease in a chinese han population. Clin Exp Hypertens. 2018;40:514–7.

    CAS  PubMed  Google Scholar 

  60. Nauck M, Winkelmann BR, Hoffmann MM, Böhm BO, Wieland H, März W. The interleukin-6 G (–174) C promoter polymorphism in the LURIC cohort: no association with plasma interleukin-6, coronary artery disease, and myocardial infarction. J Mol Med. 2002;80:507–13.

    CAS  PubMed  Google Scholar 

  61. Licastro F, Chiappelli M, Caldarera CM, Tampieri C, Nanni S, Gallina M, et al. The concomitant presence of polymorphic alleles of interleukin-1β, interleukin-6 and apolipoprotein E is associated with an increased risk of myocardial infarction in elderly men: results from a pilot study. Mech Ageing Dev. 2004;125:575–9.

    CAS  PubMed  Google Scholar 

  62. Lieb W, Pavlik R, Erdmann J, Mayer B, Holmer SR, Fischer M, et al. No association of interleukin-6 gene polymorphism (− 174 G/C) with myocardial infarction or traditional cardiovascular risk factors. Int J Cardiol. 2004;97:205–12.

    PubMed  Google Scholar 

  63. Chiappelli M, Tampieri C, Tumini E, Porcellini E, Caldarera C, Nanni S, et al. Interleukin-6 gene polymorphism is an age-dependent risk factor for myocardial infarction in men. Int J Immunogenet. 2005;32:349–53.

    CAS  PubMed  Google Scholar 

  64. Rosner SA, Ridker PM, Zee RY, Cook NR. Interaction between inflammation-related gene polymorphisms and cigarette smoking on the risk of myocardial infarction in the Physician’s Health Study. Hum Genet. 2005;118:287–94.

    PubMed  Google Scholar 

  65. Mysliwska JW, Joanna W, Hak LS, Janusz S, Rogowski JS, Krzysztof S, Mysliwski A. Interleukin 6 polymorphism corresponds to the number of severely stenosed coronary arteries. Eur Cytokine Netw. 2006;17:181–8.

    CAS  PubMed  Google Scholar 

  66. Tütün U, Aksöyek A, Ulus AT, Msrloglu M, Çiçekçioglu F, Özsk K, et al. Gene polymorphisms in patients below 35 years of age who underwent coronary artery bypass surgery. Coron Artery Dis. 2006;17:35–9.

    PubMed  Google Scholar 

  67. Maitra A, Shanker J, Dash D, John S, Sannappa PR, Rao VS, et al. Polymorphisms in the IL6 gene in Asian Indian families with premature coronary artery disease–the Indian Atherosclerosis Research Study. Thromb Haemost. 2008;99:944–50.

    CAS  PubMed  Google Scholar 

  68. Sarecka B, Zak I, Krauze J. Synergistic effects of the polymorphisms in the PAI-1 and IL-6 genes with smoking in determining their associated risk with coronary artery disease. Clin Biochem. 2008;41:467–73.

    CAS  PubMed  Google Scholar 

  69. Ghazouani L, Ben Hadj Khalifa S, Abboud N, BenHamda K, Ben Khalfallah A, Brahim N, Almawi WY, Mahjoub T. TNF-alpha-308G > A and IL-6-174G > C polymorphisms in Tunisian patients with coronary artery disease. Clin Biochem. 2010;43:1085–9.

    CAS  PubMed  Google Scholar 

  70. Rios DL, Cerqueira CC, Bonfim-Silva R, Araújo LJ, Pereira JF, Gadelha SR, et al. Interleukin-1 beta and interleukin-6 gene polymorphism associations with angiographically assessed coronary artery disease in Brazilians. Cytokine. 2010;50:292–6.

    CAS  PubMed  Google Scholar 

  71. Bennermo M, Nordin M, Lundman P, Boqvist S, Held C, Samnegård A, et al. Genetic and environmental influences on the plasma interleukin-6 concentration in patients with a recent myocardial infarction: a case–control study. J Interferon Cytokine Res. 2011;31:259–64.

    CAS  PubMed  Google Scholar 

  72. Vakili H, Ghaderian SMH, Najar RA, Panah AST, Azargashb E. Genetic polymorphism of interleukin-6 gene and susceptibility to acute myocardial infarction. Coron Artery Dis. 2011;22:299–305.

    PubMed  Google Scholar 

  73. Phulukdaree A, Khan S, Ramkaran P, Govender R, Moodley D, Chuturgoon AA. The interleukin-6 − 147 G/C polymorphism is associated with increased risk of coronary artery disease in young south african indian men. Metab Syndr Relat Disord. 2013;11:205–9.

    CAS  PubMed  Google Scholar 

  74. Galimudi RK, Spurthi MK, Padala C, Kumar KG, Mudigonda S, Reddy SG, et al. Interleukin 6 (-174G/C) variant and its circulating levels in coronary artery disease patients and their first degree relatives. Inflammation. 2014;37:314–21.

    CAS  PubMed  Google Scholar 

  75. Yang H, Wang S, Yan L, Qian P, Duan H. Association of interleukin gene polymorphisms with the risk of coronary artery disease. Genet Mol Res. 2015;14:12489–96.

    CAS  PubMed  Google Scholar 

  76. Toutouzas K, Klettas D, Anousakis-Vlachochristou N, Melidis K, Azilazian Z, Asimomiti M, et al. The-174 G > C interleukin-6 gene polymorphism is associated with angiographic progression of coronary artery disease over a 4-year period. Hellenic J Cardiol. 2017;58:80–6.

    PubMed  Google Scholar 

  77. Shabana N, Ashiq S, Ijaz A, Khalid F, Ul Saadat I, Khan K, et al. Genetic risk score (GRS) constructed from polymorphisms in the PON1, IL-6, ITGB3, and ALDH2 genes is associated with the risk of coronary artery disease in Pakistani subjects. Lipids Health Dis. 2018;17:224.

    CAS  PubMed  PubMed Central  Google Scholar 

  78. Szalai C, Füst G, Duba J, Kramer J, Romics L, Prohászka Z, et al. Association of polymorphisms and allelic combinations in the tumour necrosis factor-α-complement MHC region with coronary artery disease. J Med Genet. 2002;39:46–51.

    CAS  PubMed  PubMed Central  Google Scholar 

  79. Cheng Y, An B, Jiang M, Xin Y, Xuan S. Association of tumor necrosis factor-alpha polymorphisms and risk of coronary artery disease in patients with non-alcoholic fatty liver disease. Hepatitis Monthly. 2015;15:e26818.

    PubMed  PubMed Central  Google Scholar 

  80. Hussain S, Iqbal T, Javed Q. TNF-alpha-308G > A polymorphism and the risk of familial CAD in a Pakistani population. Hum Immunol. 2015;76:13–8.

    CAS  PubMed  Google Scholar 

  81. Kumari R, Kumar S, Ahmad MK, Singh R, Kumar SK, Pradhan A, et al. Promoter variants of TNF-α rs1800629 and IL-10 rs1800871 are independently associated with the susceptibility of coronary artery disease in north Indian. Cytokine. 2018;110:131–6.

    CAS  PubMed  Google Scholar 

  82. Georges J-L, Rupprecht HJ, Blankenberg S, Poirier O, Bickel C, Hafner G, et al. Impact of pathogen burden in patients with coronary artery disease in relation to systemic inflammation and variation in genes encoding cytokines. Am J Cardiol. 2003;92:515–21.

    CAS  PubMed  Google Scholar 

  83. Ghazouani L, Abboud N, Addad F, Khalfallah AB, Brahim N, Mediouni M, et al. –308G > A and–1031T > C tumor necrosis factor gene polymorphisms in Tunisian patients with coronary artery disease. Clin Chem Lab Med. 2009;47:1247–51.

    CAS  PubMed  Google Scholar 

  84. Sobti RC, Kler R, Sharma YP, Talwar KK, Singh N. Risk of obesity and type 2 diabetes with tumor necrosis factor-α 308G/A gene polymorphism in metabolic syndrome and coronary artery disease subjects. Mol Cell Biochem. 2012;360:1–7.

    CAS  PubMed  Google Scholar 

  85. Garg PR, Saraswathy KN, Kalla AK, Sinha E, Ghosh PK. Pro-inflammatory cytokine gene polymorphisms and threat for coronary heart disease in a North Indian Agrawal population. Gene. 2013;514:69–74.

    CAS  PubMed  Google Scholar 

  86. Chen W, Hua K, Gu H, Zhang J, Wang L. Methylenetetrahydrofolate reductase C667T polymorphism is associated with increased risk of coronary artery disease in a Chinese population. Scand J Immunol. 2014;80:346–53.

    CAS  PubMed  Google Scholar 

Download references

Acknowledgements

The authors are grateful of Deputy of Research from Neyshabur University of Medical Science.

Funding

Not applicable

Author information

Authors and Affiliations

  1. Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

    Samira Tabaei

  2. Department of Immunology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Morteza Motallebnezhad

  3. Immunology Research Center, Iran University of Medical Sciences, Tehran, Iran

    Morteza Motallebnezhad

  4. Noncommunicable Disease Research Center, Neyshabur University of Medical Science, Imam Khomeini Street, Neyshabur, 9319116911, Iran

    Seyedeh Samaneh Tabaee

  5. Faculty of Medicine, Neyshabur University of Medical Science, Neyshabur, Iran

    Seyedeh Samaneh Tabaee

Authors
  1. Samira Tabaei
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Morteza Motallebnezhad
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Seyedeh Samaneh Tabaee
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

ST performed the statistical analysis and participated in manuscript drafting. MM performed the statistical analysis, involved in conception and design, and participated in manuscript drafting. SMT developed the main idea and participated in manuscript drafting. All authors have read and approved the manuscript.

Corresponding author

Correspondence to Seyedeh Samaneh Tabaee.

Ethics declarations

Conflict of interest

The authors declare that they have no competing interests.

Ethics approval

Not applicable.

Consent to participate

Not applicable.

Consent for publication

All authors read the manuscript and consent for its publication.

Additional information

Responsible Editor: John Di Battista.

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tabaei, S., Motallebnezhad, M. & Tabaee, S.S. Systematic review and meta-analysis of association of polymorphisms in inflammatory cytokine genes with coronary artery disease. Inflamm. Res. 69, 1001–1013 (2020). https://doi.org/10.1007/s00011-020-01385-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00011-020-01385-3

Keywords

Search

Navigation