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Hypolipidemic Lactone Derivatives from Highland Barley Monascus

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Chemistry of Natural Compounds Aims and scope

A new lactone, named 9-allyl-5-methyl-1H-difuro-isochromene-1,8-dione (1), together with nine known lactone derivatives (2–10), was isolated from highland barley Monascus for the first time. Compounds 1–10 were studied by spectroscopic methods and comparison with references and evaluated for their hypolipidemic activities by measuring the triglyceride content in HepG2 cells with simvastatin as positive control. Among them, compounds 1 and 7 (10 μM) exhibited moderate hypolipidemic activities.

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Acknowledgment

This study was supported by the Science and Technology Project of Jiangxi Health Commission (20195648).

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Authors and Affiliations

  1. Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Key Laboratory of Modern Preparation of TCM of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, 330004, Nanchang, Jiangxi, P. R. China

    Rongrui Wei & Qinge Ma

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  1. Rongrui Wei
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  2. Qinge Ma
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Correspondence to Qinge Ma.

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Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2020, pp. 525–527.

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Wei, R., Ma, Q. Hypolipidemic Lactone Derivatives from Highland Barley Monascus. Chem Nat Compd 56, 607–610 (2020). https://doi.org/10.1007/s10600-020-03104-0

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  • DOI: https://doi.org/10.1007/s10600-020-03104-0

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