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A New Sesquiterpene Lactone from Eupatorium chinense and its Anti-TNBC Activity

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Chemistry of Natural Compounds Aims and scope

A new sesquiterpene lactone, namely, eupachiilide A (1), as well as two known sesquiterpene lactones, eupachinilide B (2), and eupalinilide G (3), were isolated from the whole plant of Eupatorium chinense L. The new structure was elucidated by spectral methods, especially 2D NMR techniques. The three natural compounds were all Michael addition acceptors, whose electrophilic moiety could react with the nucleophilic residues of the relevant active site and produce a variety of bioactivities. Eupachiilide A demonstrated potent cytotoxicity against two TNBC cell lines.

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Acknowledgment

The work was financially supported by the National Natural Science Foundation of China (81773868), the Natural Science Foundation of Zhejiang Province (LY17H280004), the Zhejiang Province Chinese medicine scientific research fund project (2016ZA050), and the Hangzhou Major Science and Technology Project (20172016A01).

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Authors and Affiliations

  1. College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou, 311402, P. R. China

    Qing-li Jiang, Pan-ting Shou, Min-juan Sun, Guan-feng Wang, Hua-jun Zhao & Bo Yang

  2. Department of Clinical Pharmacology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Hangzhou First People′s Hospital, Zhejiang Chinese Medical University, Hangzhou, 310006, P. R. China

    Neng-ming Lin

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  1. Qing-li Jiang
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  2. Pan-ting Shou
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  3. Min-juan Sun
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  4. Guan-feng Wang
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  5. Neng-ming Lin
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  6. Hua-jun Zhao
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  7. Bo Yang
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Corresponding authors

Correspondence to Neng-ming Lin, Hua-jun Zhao or Bo Yang.

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Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2020, pp. 565–568.

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Jiang, Ql., Shou, Pt., Sun, Mj. et al. A New Sesquiterpene Lactone from Eupatorium chinense and its Anti-TNBC Activity. Chem Nat Compd 56, 651–655 (2020). https://doi.org/10.1007/s10600-020-03114-y

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  • DOI: https://doi.org/10.1007/s10600-020-03114-y

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