To find potent antioxidants, 16 novel Trolox derivatives were designed and synthesized via a reduction and esterification reaction. The chemical structures were characterized by NMR and MS. Trolox derivatives were employed to explore the potential structure–antioxidant activity relationships using three different assays. The results revealed that some of the synthesized compounds exhibited stronger antioxidant activities than L-ascorbic acid and Trolox, which suggests such compounds warrant further study.
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Acknowledgment
This work is supported by the Science and Technology Development Funds of Jilin Province (No. 20160520044JH) and the Science and Technology Projects of Administration of Traditional Chinese Medicine of Jilin Province (No. 2019145). We thank James Murray, PhD of Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript.
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Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2020, pp. 560–564.
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Xu, Q., Zhang, L., Zhan, D. et al. Synthesis and Antioxidant Activity Evaluation of Trolox Derivatives. Chem Nat Compd 56, 645–650 (2020). https://doi.org/10.1007/s10600-020-03113-z
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DOI: https://doi.org/10.1007/s10600-020-03113-z