Poorly controlled epilepsy at baseline, more AEDs at baseline, medication non-compliance, increase in self-reported stress and altered sleep patterns are risk factors for increase in seizure frequency during the pandemic
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Students, duration of epilepsy less than 5 years, history of psychiatric illness and use of psychiatric medications are risk factors for increase self-reported stress in PWE
Abstract
Objectives
The objective of the study was to assess if patients with epilepsy (PWE) experienced an increase in seizure frequency and self-reported stress during the COVID-19 pandemic.
Methods
This is a cross-sectional study conducted in Saudi Arabia in April 2020. An electronic self-administered questionnaire was distributed to PWE via their treating neurologist. The variables included were demographic and baseline clinical characteristics (age, gender, living situation, occupational status, type of epilepsy, duration of epilepsy, number of antiepileptic medications (AEDs), presence of known psychiatric illness, and use of psychiatric medications), their seizure control in the month prior to the pandemic, perceived stress during this period of time, sleep changes, compliance changes, and change in seizure control during the pandemic.
Results
A total of 156 patients completed the questionnaire, with 29.5% reporting an increase in seizure frequency. Additionally, 59.4% reported an increase in self-reported stress and 71.2% experienced a significant change in their sleep during this period. Higher baseline seizure frequency, more AEDs, noncompliance, increase in self-reported stress, and sleep changes are the significant factors associated with increase in seizure frequency during the pandemic.
Conclusion
Identifying high-risk patients for seizure recurrence is important in order to provide them with adequate support to reduce such risk.
