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A new luminescent Zn(II) coordination polymer: selective detection of TNP and enhancement activity on sepsis by regulating the miR-16 expression in immune cells

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Abstract

A novel coordination polymer based on Zn(II) ions as nodes, {[Zn2TTPA(GA)2]·2H2O}n, has been successfully synthesized by employment of tris[4-(1H-1,2,4-triazol-1-yl)phenyl]amine (TTPA), a 1,2,4-triazole derivative with the presence of the flexible glutaric acid (H2GA) ligand with Zn(II) nitrate salts. Luminescent detection experiments show that the complex could be applied as a sensor for 2,4,6-trinitrophenol via the luminescence quenching. To develop new candidates for the sepsis treatment in clinic and evaluate the influence of the compound on the immune cells, the western blotting was conducted to detect the activation of the anti-bacterial response in the macrophages after compound treatment under infection. The relative expression levels of the miR-16 in the immune cells was measured for revealing the detail mechanism of the compound.

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Authors and Affiliations

  1. The Third Department of Oncology, The First Affiliated Hospital of Kangda College of Nanjing Medical University (The First People’s Hospital of Lianyungang), Lianyungang, Jiangsu, China

    Xiang Li, Wei-Jing Zhao, Lei Zhang & Xia Zhou

  2. Department of Medicine, Dalian Medical University, Dalian, Liaoning, China

    Dong-Ping Yu & Bing-Bing Shang

Authors
  1. Xiang Li
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  2. Wei-Jing Zhao
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  3. Lei Zhang
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  4. Dong-Ping Yu
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  5. Bing-Bing Shang
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  6. Xia Zhou
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Correspondence to Xia Zhou.

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Li, X., Zhao, WJ., Zhang, L. et al. A new luminescent Zn(II) coordination polymer: selective detection of TNP and enhancement activity on sepsis by regulating the miR-16 expression in immune cells. Monatsh Chem 151, 1069–1076 (2020). https://doi.org/10.1007/s00706-020-02648-9

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  • DOI: https://doi.org/10.1007/s00706-020-02648-9

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