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4-Methyl-7-Amino/Amido Coumarin Derivatives as Potential Antimicrobials and Antioxidants

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Chemistry of Natural Compounds Aims and scope

An array of previously synthesized 4-methyl-7-amino and amido coumarins 4a–u has been screened for their antimicrobial and antioxidant properties. Some of the compounds exhibited promising antibacterial and antifungal activities (MIC ranging from 4–64 μg/mL) when compared to the respective standards. Compound 4u showed comparable antibacterial activity with the standard, ciprofloxacin, whereas compounds 4u and 4t displayed promising antifungal activity when compared to the standard, fluconazole. The in silico docking studies against gyrase enzyme revealed the fact that 4u possessed hydrogen bonding and significant hydrophobic interactions, which may be the reason for its superior antibacterial activity as compared to the other compounds. Compounds 4c and 4m showed comparable antioxidant activity with the standard, BHT, which can be attributed to the presence of electron-donating substituents.

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Authors and Affiliations

  1. Innovation Center for Chemical and Pharmaceutical Technologies, Ural Federal University, 19 Mira Street, 620002, Yekaterinburg, Russia

    Muthipeedika Nibin Joy

  2. Department of P.G Studies and Research in Industrial Chemistry, Kuvempu University, Jnana Sahyadri, Shankaraghatta, Shimoga, Karnataka, 577451, India

    Muthipeedika Nibin Joy & Yadav D. Bodke

  3. Department of P.G Studies and Research in Biotechnology, Kuvempu University, Jnana Sahyadri, Shankaraghatta, Shimoga, Karnataka, 577451, India

    Sandeep Telkar

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  1. Muthipeedika Nibin Joy
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  2. Yadav D. Bodke
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  3. Sandeep Telkar
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Correspondence to Muthipeedika Nibin Joy.

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Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2020, pp. 531–536.

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Joy, M.N., Bodke, Y.D. & Telkar, S. 4-Methyl-7-Amino/Amido Coumarin Derivatives as Potential Antimicrobials and Antioxidants. Chem Nat Compd 56, 614–620 (2020). https://doi.org/10.1007/s10600-020-03106-y

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  • DOI: https://doi.org/10.1007/s10600-020-03106-y

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