Abstract
Green chemistry aims at developing reactions that are cheap, clean and use less energy. For that, multicomponent reactions are drawing attention, yet, actual methods involve complicated work-ups, hazardous solvents, toxic catalysts, high catalyst loads, harsh reaction conditions and tedious catalyst preparation. Here, we demonstrate that the commercially available reagent, 9-mesityl-10 methylacridinium perchlorate (Acr+-Mes ClO4−), can serve as a photocatalyst in the presence of a blue lamp light source, promoting the synthesis of 2-amino-4H-chromenes via a multicomponent reaction with low catalyst loadings. A wide range of aromatic aldehydes readily undergo condensation with malononitrile and ArOH-type structural motifs under mild conditions to afford the products in 76–95% yield within 60 min.
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Acknowledgements
The authors are grateful to the funds of Innovation Project of Guang Dong Graduate Education (2020SFKC065), Science Foundation for Young Teachers of Wuyi University (2019td06), the Foundation of the Department of Education of Guangdong Province (2016KCXTD005, 2017KZDXM085, 2018KZDXM070 and 2019KZDXM052) and Innovation Project of Wuyi University Graduate Education (2020XJ012).
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Chen, L., Lin, C., Lan, Y. et al. Visible light-induced green synthesis of 2-amino-4H-chromenes. Environ Chem Lett 18, 2157–2163 (2020). https://doi.org/10.1007/s10311-020-01053-2
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DOI: https://doi.org/10.1007/s10311-020-01053-2