Guanylate-binding proteins (GBPs) promote immune defenses against infectious agents. Two studies reveal that GBP1 directly binds to cytosolic lipopolysaccharide (LPS), bringing caspase-4 to the surface of bacteria to induce pyroptosis.
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10 September 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Feng, S., Man, S.M. Captain GBP1: inflammasomes assemble, pyroptotic endgame. Nat Immunol 21, 829–830 (2020). https://doi.org/10.1038/s41590-020-0727-0
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DOI: https://doi.org/10.1038/s41590-020-0727-0
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