Rho family GTPases regulate cell behaviors through complex signaling networks that act on rapid timescales in subcellular spatial domains. New live-cell biosensors and analytical methods now provide critical tools to dissect Rho GTPase regulation and to better understand cellular information processing.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
Purchase on Springer Link
Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Jaffe, A. B. & Hall, A. Annu. Rev. Cell Dev. Biol. 21, 247–269 (2005).
Marston, D. J. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-020-0542-9 (2020).
Jaiswal, M., Dvorsky, R. & Ahmadian, M. R. J. Biol. Chem. 288, 4486–4500 (2013).
Guilluy, C., Garcia-Mata, R. & Burridge, K. Trends Cell Biol. 21, 718–726 (2011).
Rossman, K. L., Der, C. J. & Sondek, J. Nat. Rev. Mol. Cell Biol. 6, 167–180 (2005).
Nobes, C. D. & Hall, A. Cell 81, 53–62 (1995).
Goedhart, J. & van Unen, J. Small GTPases 10, 178–186 (2019).
Machacek, M. et al. Nature 461, 99–103 (2009).
Yang, H. W., Collins, S. R. & Meyer, T. Nat. Cell Biol. 18, 191–201 (2016).
Tischer, D. & Weiner, O. D. Nat. Rev. Mol. Cell Biol. 15, 551–558 (2014).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Natwick, D.E., Collins, S.R. Decoding GEFs of animated cells. Nat Chem Biol 16, 812–813 (2020). https://doi.org/10.1038/s41589-020-0570-5
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41589-020-0570-5