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Anti-inflammatory Effects of Lecania gerlachei Extract Collected from the Antarctic King Sejong Island

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  • Biomedical Engineering
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Abstract

Chronic inflammation is the cause of various diseases such as rheumatoid arthritis and asthma, with a large number of people suffering from them. There have been many reports that even link cancer to inflammation, so the development of sophisticated and powerful drugs continues to be in demand. Here we demonstrate that the methanol extract of Lecania gerlachei (LGME), a lichen member found in the extreme Antarctic environment, exhibits anti-inflammatory activities. Treatment of lipopoly-saccharide (LPS) stimulated Raw 264.7 murine macrophage cells with LGME reduced nitric oxide (NO) immune modulator production, and also down-regulated inducible nitric oxide synthase (iNOS), pro-inflammatory interleukin 6, 1ß and 1α (IL-6, IL-1ß and IL-1α), and tumor necrosis factor α (TNF-α) at both transcript and protein levels, in a concentration dependent manner. Furthermore, it was found that these effects were mediated by nuclear factor kappa B (NF-κB) signaling inhibition. Thus, our findings may contribute towards the development of novel inflammatory drugs.

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Acknowledgements

This work was supported by the Korea Polar Research Institute (KOPRI) of the Republic of Korea, under project PE20010.

The authors declare no conflict of interest.

Neither ethical approval nor informed consent was required for this study.

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Authors and Affiliations

  1. Division of Polar Life Science, Korea Polar Research Institute, Incheon, 21990, Korea

    Seul Ki Min, Jung Eun Kim, Ju-Mi Hong, Joung Han Yim, Ui Joung Youn, Se Jong Han & Il-Chan Kim

  2. School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Korea

    Jung Eun Kim

  3. Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Korea

    Hyun Park

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  1. Seul Ki Min
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Min, S.K., Kim, J.E., Hong, JM. et al. Anti-inflammatory Effects of Lecania gerlachei Extract Collected from the Antarctic King Sejong Island. Biotechnol Bioproc E 25, 543–550 (2020). https://doi.org/10.1007/s12257-019-0371-4

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